Total knee replacement Clinical Trials

Recruiting total knee replacement studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat total knee replacement. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting total knee replacement studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting total knee replacement trials

Within

Balance, Fall Risk, and Gait in Women With Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Karabuk University

Sex: Female·Age: 60 - 85·Accepts healthy volunteers

Code: NCT07650175

Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty

for Postoperative Pain Following Knee Arthroplasty

Sponsor: Ömer Kayar

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07577869

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Utilization of a 3D Printed Mechanical Balancer During Total Knee Arthroplasty (TKA)

for Total Knee Arthroplasty

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT06654661

Oral Tranexamic Acid After Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06894719·Phase 4

Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty.

for Total Knee Arthroplasty

Sponsor: CMC Ambroise Paré

Sex: All·Age: 18+

Code: NCT07477730

Methadone in the Management of Post-Operative Pain in Total Knee Replacement

for Total Knee Arthroplasty

1 site in Denver

Sponsor: AdventHealth

Sex: All·Age: 21 - 75

Code: NCT07485803·Phase 4

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Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery

for Total Knee Arthroplasty

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT07584915·Phase 4

GENicular Nerve Block in KNEE Arthroplasty

for Osteoarthritis (OA) of the Knee

Sponsor: Helse Møre og Romsdal HF

Sex: All·Age: 18 - 80

Code: NCT07589127

IO Vancomycin Administration in TKA

for Total Knee Arthroplasty

1 site in San Diego

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07633418·Phase 4

Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty

for Postoperative Cognitive Dysfunction (POCD)

Sponsor: Odense University Hospital

Sex: All·Age: 70+

Code: NCT07598552

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Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients

for Knee Osteoarthritis

Sponsor: Ataturk University

Sex: All·Age: 55+

Code: NCT07545447

Adductor Canal Block With or Without Biceps Femoris Short Head Block in Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Cukurova University

Sex: All·Age: 18 - 80

Code: NCT07568106

Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: TC Erciyes University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07586436

Infiltration or Nerve Blocks in Addition to Adductor Canal Block

for Gonarthrosis

Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche

Sex: All·Age: 18+

Code: NCT06920186

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Adductor Canal Block Methods in Bilateral Total Knee Arthroplasty

for Knee Osteoarthritis

Sponsor: Yonsei University

Sex: All·Age: 60+

Code: NCT07506629

Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Social Medical Corporation Daiyukai

Sex: All·Age: 20+

Code: NCT07524387

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Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty

for Knee Osteoarthritis

Sponsor: Haseki Training and Research Hospital

Sex: All·Age: 50 - 80

Code: NCT07442812

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Binaural Beats for Postoperative Pain and Anxiety Reduction

for TKA

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18 - 99

Code: NCT07437469

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AI-based Rehabilitation for Hip and Knee Surgery Patients

for Total Knee Arthroplasty

Sponsor: Gangnam Severance Hospital

Sex: All·Age: 19+

Code: NCT07505628

REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes

for Total Knee Arthroplasty

Sponsor: Université de Sherbrooke

Sex: All·Age: 18+

Code: NCT07511842

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The Effects of Dual-Task Exercises on Parameters After Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Yuzuncu Yil University

Sex: All·Age: 50 - 65

Code: NCT07416877

Methylene Blue in Total Knee Arthroplasty (TKA)

for Total Knee Arthroplasty

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07324954·Phase 1

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Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty

for Osteoarthritis, Knee

Sponsor: Hospital Italiano de Buenos Aires

Sex: All·Age: 18+

Code: NCT07630337

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Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Copenhagen University Hospital, Hvidovre

Sex: All·Age: All ages

Code: NCT07067060

ERAS-Based Preoperative Nutrition and Fasting in Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Nermin Ocaktan

Sex: All·Age: 18+

Code: NCT07336160

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Impact of ABC-X Model Nursing on Psychological Resilience and Family Function in TKA Patients

for Total Knee Arthroplasty

Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Sex: All·Age: 30 - 65

Code: NCT07335809

Postoperative Analgesic Efficacy Between Adductor Canal Block + IPACK Block and Adductor Canal Block + Genicular Nerve Block in Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Konya Beyhekim Training and Research Hospital

Sex: All·Age: 18+

Code: NCT07324486

Minimal Sedation During Knee Replacement Surgery

for Total Knee Arthroplasty

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07371390

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Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty

for Knee Osteoarthritis

Sponsor: Ataturk University

Sex: All·Age: 18 - 75

Code: NCT07248072

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Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Total Knee Arthroplasty: A Randomized Controlled Comparison of Sciatic, BiFeS, and IPACK Techniques

for Post Operative Analgesia

Sponsor: Erzincan University

Sex: All·Age: 18 - 75

Code: NCT07242170

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Biological Link Between Anxiety and Outcomes Post Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

Sex: All·Age: 18 - 85

Code: NCT07102563

Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty

for Postoperative Pain

Sponsor: Hitit University

Sex: All·Age: 18 - 80

Code: NCT07561333

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IMProving Outcomes With ACT After Knee Surgery

for Total Knee Arthroplasty

Sponsor: Belfast Health and Social Care Trust

Sex: All·Age: 18 - 100

Code: NCT06483191

Virtual Reality During Passive Motion After Knee Surgery

for Total Knee Arthroplasty

Sponsor: Manisa Celal Bayar University

Sex: All·Age: 18+

Code: NCT07177573

Mako Cementless TKA vs Mako Cemented TKA

for Total Knee Replacement

Sponsor: University College, London

Sex: All·Age: 18+

Code: NCT06929871

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Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty

for Pain, Postoperative

Sponsor: The University of Hong Kong

Sex: All·Age: 18 - 80

Code: NCT06740214·Phase 3

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Investigating Patient Satisfaction With Smart Knee Implants

for Total Knee Arthroplasty

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06968143

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Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA）

for Total Knee Arthroplasty

Sponsor: ScinnoHub Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 70

Code: NCT07127042·Phase 2

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Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

for Total Knee Arthroplasty

1 site in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: All ages

Code: NCT06946368

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Patients' Experiences of Information After Total Knee Arthroplasty - A Qualitative Interview Study

for Knee Osteoarthrosis

Sponsor: Vastra Gotaland Region

Sex: All·Age: All ages

Code: NCT06994884

Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery

for Anterior Cruciate Ligament Reconstruction

1 site in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07020312·Phase 2

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Regional Anesthesia in TKA: Impact on Postoperative Joint Motion and Patient Satisfaction

for Total Knee Arthroplasty

Sponsor: Konya City Hospital

Sex: All·Age: 18+

Code: NCT07124494

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Comparison of Two Different Regional Anesthetic Methods in Total Knee Arthroplasty Patients

for Total Knee Arthroplasty

Sponsor: SB Istanbul Education and Research Hospital

Sex: All·Age: 18 - 75

Code: NCT07092982

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Patient-navigation-based Preoperative Rehabilitation Exercise Program in Patients Undergoing TKA

for Total Knee Arthroplasty

Sponsor: Anna Sun

Sex: All·Age: 45 - 90·Accepts healthy volunteers

Code: NCT07047079

Robotic-Assisted Total Knee Arthroplasty: Cruciate-Retaining Versus Bi-Cruciate Stabilized

for Knee Osteoarthritis

Sponsor: Chinese University of Hong Kong

Sex: All·Age: 18+

Code: NCT06838663

The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

for Post-Operative Pain

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT06991231

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Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.

for Total Hip Arthroplasty (THA)

Sponsor: JointResearch

Sex: All·Age: All ages

Code: NCT07053943

Gait in Fixed Or Rotating Cementless Total Knee Arthroplasties

for Total Knee Arthroplasty

Sponsor: Belfast Health and Social Care Trust

Sex: All·Age: 18 - 65

Code: NCT06483178

Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)

for Total Knee Arthroplasty

1 site in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+

Code: NCT06640491·Phase 1, Phase 2

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Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

for Total Knee Arthroplasty

3 sites incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT06953375

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Intra-Articular Catheter Total Knee Arthroplasty

for Continuous Local Infiltration Analgesia

1 site in Charlotte

Sponsor: OrthoCarolina Research Institute, Inc.

Sex: All·Age: 18+

Code: NCT06580899·Phase 4

Kinematic and Mechanical Alignment Randomized Trial

for Total Knee Arthroplasty

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT06787417·Phase 4

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Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty

for Intrathecal Dexmedetomidine

Sponsor: Kafrelsheikh University

Sex: All·Age: 18 - 75

Code: NCT06837844

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Branched Chain Amino Acids for Sarcopenia in Patients Undergoing Total Knee Arthroplasty

for Sarcopenia

Sponsor: Seoul National University Hospital

Sex: All·Age: 40 - 100

Code: NCT07634523·Phase 4

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Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

for Osteoarthritis, Knee

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 50+

Code: NCT06083480·Phase 4

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Can the Use of Virtual Reality Improve TKA Outcomes

for Total Knee Arthroplasty

Sponsor: Belfast Health and Social Care Trust

Sex: All·Age: 18 - 100

Code: NCT06962046

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Observation of Wheeled Device Use After TKA

for Total Knee Arthroplasty

1 site in Redwood City

Sponsor: Stanford University

Sex: All·Age: 18 - 99

Code: NCT06080152

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Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: University Hospital, Bonn

Sex: All·Age: 18+

Code: NCT06947655

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Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA

for Total Knee Arthroplasty

Sponsor: First Affiliated Hospital of Fujian Medical University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06600815

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Multimodal Biopsychosocial Teleprehabilitation for Total Knee Arthroplasty

for Total Knee Arthroplasty

Sponsor: Universitair Ziekenhuis Brussel

Sex: All·Age: 18+

Code: NCT06565377

Apply to this trial

Total knee replacement clinical trials — common questions

Are total knee replacement clinical trials free to join?

Yes. Participating in a total knee replacement clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a total knee replacement clinical trial?

Each total knee replacement study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a total knee replacement trial near me?

Use the location controls above. We'll show recruiting total knee replacement trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many total knee replacement trials are recruiting right now?

We're currently tracking roughly 22 recruiting total knee replacement trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Total knee replacement trials by city

Aurora, CO Chicago, IL Cleveland, OH Miami, FL San Diego, CA Denver, CO Los Angeles, CA Redwood City, CA

Related specialties

Orthopedics