Osteosarcoma Clinical Trials

Recruiting osteosarcoma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat osteosarcoma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting osteosarcoma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting osteosarcoma trials

Within

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

for Pediatric Solid Tumors

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT07514819

my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults

for Sarcoma

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15 - 24

Code: NCT07516353

Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma

for Osteosarcoma

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: Up to 50

Code: NCT06492954·Phase 1

Apply to this trial

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

for Osteosarcoma

2 sites incl. Tampa

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 0 - 50

Code: NCT07321912·Phase 2

Apply to this trial

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

for Atypical Teratoid/Rhabdoid Tumor

12 sites incl. Birmingham

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 26

Code: NCT06465199·Phase 1, Phase 2

Apply to this trial

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

Apply to this trial

A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma

for Osteosarcoma

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 6 - 49

Code: NCT07477457·Phase 2

Apply to this trial

Apatinib Combined With Liposomal Irinotecan for Refractory or Metastatic Osteosarcoma

for Osteosarcoma

Sponsor: Peking University People's Hospital

Sex: All·Age: 12 - 65

Code: NCT07479732·Phase 1, Phase 2

Apply to this trial

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

for Neuroblastoma

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 6 Months - 25

Code: NCT06625190·Phase 1, Phase 2

Apply to this trial

Musculoskeletal Cancers Remote Monitoring and Care

for Osteosarcoma

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07129226

Apply to this trial

Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas

for Osteosarcoma

Sponsor: Tcelltech Inc.

Sex: All·Age: 8+

Code: NCT07052383·Phase 1

Apply to this trial

Envafolimab Combined With Neoadjuvant Chemotherapy Treat Stage IIb Resectable Osteosarcoma Patients

for Osteosarcoma

Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Sex: All·Age: 12 - 70

Code: NCT07142863·Phase 2

Precision Therapy Based on Immune Microenvironment by Transcriptome Sequencing of Osteosarcoma, a Prospective, Multi-cohort Exploratory Clinical Study

for Osteosarcoma

Sponsor: Peking University People's Hospital

Sex: All·Age: 8 - 70

Code: NCT06776198

Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy

for Oral Cancer

Sponsor: University Medical Center Groningen

Sex: All·Age: 18+

Code: NCT06726512

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

for Sarcoma

3 sites in Boston

Sponsor: David S Shulman, MD

Sex: All·Age: 12 - 49

Code: NCT06709495·Phase 1, Phase 2

Apply to this trial

A Phase 2 Pilot Study to Evaluate the Safety and the Anti-Tumour Activity of the Myc Inhibitor OMO-103 Administered Intravenously in Patients With Advanced High-Grade Osteosarcoma

for Osteosarcoma

Sponsor: Vall d'Hebron Institute of Oncology

Sex: All·Age: 12+

Code: NCT06650514·Phase 2

Apply to this trial

ARTEMIS-103: Phase 1b Study of HS-20093 Combinations in Patients with Bone and Soft Tissue Sarcoma.

for Osteosarcoma

Sponsor: Hansoh BioMedical R&D Company

Sex: All·Age: 18+

Code: NCT06699576·Phase 1

PET-imaging of Two Vartumabs in Patients With Solid Tumors

for Solid Tumor

Sponsor: Var2 Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06645808·EARLY_Phase 1

Apply to this trial

Cryoablation Plus Camrelizumab for Advanced Soft Tissue Sarcoma

for Soft Tissue Sarcoma (STS)

Sponsor: Sun Yat-sen University

Sex: All·Age: 14 - 70

Code: NCT07602049·Phase 2

Apply to this trial

Trilaciclib Combing Chemotherapy in the Neoadjuvant Treatment of Osteosarcoma

for Osteosarcoma

Sponsor: Peking University People's Hospital

Sex: All·Age: 14 - 70

Code: NCT06714383·Phase 2

Apply to this trial

Assessing Clinical Trial Experiences of Patients With Osteosarcoma

for Osteosarcoma

Sponsor: Power Life Sciences Inc.

Sex: All·Age: 18+

Code: NCT05535283

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

for Neuroblastoma

21 sites incl. Birmingham

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 30

Code: NCT06541262·Phase 1, Phase 2

Apply to this trial

Tumor Neoantigen Vaccine SarVac Combined With Tumor Specific Lymphocyte Reinfusion in the Treatment of Advanced Sarcoma

for Soft Tissue Sarcoma (STS)

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 70

Code: NCT07648069·Phase 1

Apply to this trial

Single High-dose Brachytherapy for Giant Osteosarcoma Masses

for Osteosarcoma

Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Sex: All·Age: 12 - 70

Code: NCT06524778·Phase 2

Agnostic Therapy in Rare Solid Tumors

for Urachal Cancer

Sponsor: Instituto do Cancer do Estado de São Paulo

Sex: All·Age: 18+

Code: NCT06638931·Phase 2

Apply to this trial

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors

for Neuroblastoma

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 2 - 30

Code: NCT06500819·Phase 1

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Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

for Osteosarcoma

1 site in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 6 - 17

Code: NCT06235125·Phase 1

Apply to this trial

Upfront Surgical Resection for Osteosarcoma

for Osteosarcoma

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 5 - 40

Code: NCT06384404

Apply to this trial

A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning

for Sarcoma, Ewing

3 sites incl. Oakland

Sponsor: Ricoh USA, Inc.

Sex: All·Age: 13+

Code: NCT06387485

Apply to this trial

An Organoid-based Functional Precision Medicine Trial in Osteosarcoma

for Osteosarcoma

1 site in Los Angeles

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: All ages

Code: NCT06064682

Apply to this trial

Donor Site Morbidity After Free Vascularized Fibular Graft

for Osteosarcoma

Sponsor: Assiut University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06324916

Apply to this trial

A Clinical Study of Surufatinib Combined With Chemotherapy as Neoadjuvant Treatment in Osteosarcoma

for Osteosarcoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 2 - 70

Code: NCT05926492·Phase 2

Apply to this trial

B7-H3 NIR Imaging for Osteosarcoma Surgery

for Osteosarcoma

Sponsor: Peking University People's Hospital

Sex: All·Age: 18 - 60

Code: NCT06778603·Phase 1, Phase 2

Apply to this trial

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

4 sites incl. San Francisco

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1

Apply to this trial

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy

for Chordoma

Sponsor: Centre Antoine Lacassagne

Sex: All·Age: 18+

Code: NCT06029218

Apply to this trial

SPEARHEAD-3 Pediatric Study

for Synovial Sarcoma

10 sites incl. Palo Alto

Sponsor: USWM CT, LLC

Sex: All·Age: 2 - 21

Code: NCT05642455·Phase 1, Phase 2

Apply to this trial

ARTEMIS-002: HS-20093 in Patients With Relapsed or Refractory Osteosarcoma and Other Sarcomas

for Osteosarcoma

Sponsor: Hansoh BioMedical R&D Company

Sex: All·Age: 18+

Code: NCT05830123·Phase 2

Apply to this trial

Pulmonary Resectable Osteosarcoma Treated by Metastasectomy and Pre-operative Immunotherapy and Stereotactic Body Radiotherapy (PROMIS): a Prospective Clinical Trial

for Osteosarcoma

Sponsor: Ruijin Hospital

Sex: All·Age: 10 - 65

Code: NCT06114225·Phase 2

Apply to this trial

Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Progressive Osteosarcoma

for Osteosarcoma

1 site in Cleveland

Sponsor: MedPacto, Inc.

Sex: All·Age: 12+

Code: NCT05588648·Phase 1, Phase 2

Apply to this trial

Use of GnRHa During Chemotherapy for Fertility Protection

for Breast Cancer Female

Sponsor: Kenny Rodriguez-Wallberg

Sex: Female·Age: 14 - 42

Code: NCT05328258·Phase 3

Apply to this trial

START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer

for Melanoma (Skin)

Sponsor: Valo Therapeutics Oy

Sex: All·Age: 18+

Code: NCT05492682·Phase 1

Apply to this trial

A Study of Sulfatinib on Relapsed or Refractory Drug Resistant Osteosarcoma

for Osteosarcoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 2 - 25

Code: NCT05590572·Phase 1, Phase 2

Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery

for Osteosarcoma

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 12 - 90

Code: NCT05779670

Apply to this trial

Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas

for Osteosarcoma

Sponsor: Klinikum Stuttgart

Sex: All·Age: All ages

Code: NCT05515068

AOH1996 for the Treatment of Refractory Solid Tumors

for Refractory Malignant Solid Neoplasm

2 sites incl. Scottsdale

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05227326·Phase 1

Apply to this trial

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

for Pediatric Solid Tumor

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT04897321·Phase 1

Apply to this trial

An Observational Study of Local Relapse After High Grade Osteosarcoma

for Osteosarcoma

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: All ages

Code: NCT06017518

Apply to this trial

Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas

for Soft Tissue Sarcoma Adult

Sponsor: Institut Bergonié

Sex: All·Age: 18+

Code: NCT05182164·Phase 2

Apply to this trial

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

211 sites incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3

Apply to this trial

Early Ageing During Therapy in AYA Cancer Patients

for Cancer

Sponsor: University Medical Center Groningen

Sex: All·Age: 18 - 39

Code: NCT05062707

Apply to this trial

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

for Sarcoma

1 site in Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 1 - 25

Code: NCT04995003·Phase 1

Apply to this trial

Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients

for Bone Sarcoma

Sponsor: Centre Leon Berard

Sex: All·Age: 12+

Code: NCT04698785·Phase 2

Apply to this trial

Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

for Desmoplastic Small Round Cell Tumor

5 sites incl. Atlanta

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 39

Code: NCT04616560·Phase 1, Phase 2

Apply to this trial

Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse

for Osteosarcoma

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 14+

Code: NCT04758000·Phase 2

Apply to this trial

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

for Solid Tumor, Adult

3 sites incl. Scottsdale

Sponsor: BioEclipse Therapeutics

Sex: All·Age: 18+

Code: NCT04282044·Phase 1

Apply to this trial

Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas

for Bone Sarcoma

Sponsor: Centre Leon Berard

Sex: All·Age: 12+

Code: NCT04055220

Apply to this trial

ICONIC: Improving Outcomes Through Collaboration in OsteosarComa

for Osteosarcoma

Sponsor: University College, London

Sex: All·Age: All ages

Code: NCT04132895

Apply to this trial

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

for Chondrosarcoma

4 sites incl. Jacksonville

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT04040205·Phase 2

Apply to this trial

Losartan + Sunitinib in Treatment of Osteosarcoma

for Osteosarcoma

4 sites incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 10+

Code: NCT03900793·Phase 1

Apply to this trial

Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

for Neuroblastoma

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 Months+

Code: NCT03721068·Phase 1

Apply to this trial

Osteosarcoma clinical trials — common questions

Are osteosarcoma clinical trials free to join?

Yes. Participating in a osteosarcoma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a osteosarcoma clinical trial?

Each osteosarcoma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a osteosarcoma trial near me?

Use the location controls above. We'll show recruiting osteosarcoma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many osteosarcoma trials are recruiting right now?

We're currently tracking roughly 29 recruiting osteosarcoma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Osteosarcoma trials by city

Birmingham, AL Palo Alto, CA Boston, MA Cleveland, OH Gainesville, FL Los Angeles, CA Chicago, IL Jacksonville, FL Madison, WI Oakland, CA Orange, CA San Francisco, CA

Related specialties

Oncology Pediatric oncology