Postoperative pain Clinical Trials

Recruiting postoperative pain studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat postoperative pain. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting postoperative pain studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting postoperative pain trials

Within

Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery

for Postoperative Pain

Sponsor: University of Alexandria

Sex: All·Age: 18 - 65

Code: NCT04110132

Psilocybin After Trauma Surgery for Pain

for Pain Management

1 site in Pittsburgh

Sponsor: Trent Emerick

Sex: All·Age: 25 - 65

Code: NCT07406828·Phase 1

ESP Blocks for Posterior Spinal Fusion

for Postoperative Pain

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07228039·Phase 4

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

for Distal Radius Fracture

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05318729

Study of QL Analgesic Response and Extent

for Acute Pain

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07566312·Phase 4

A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery

for Postoperative Pain

Sponsor: Chaw Sook Hui

Sex: All·Age: 18 - 75

Code: NCT07803575

Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME)

for Postoperative Pain

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07624006·Phase 4

Intertransverse Process Block Versus Subcostal Transversus Abdominis Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591129

Intertransverse Process Block Versus External Oblique Intercostal Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591116

A Comparison Between The Efficacy of Modified Thoracoabdominal Plane Block Via Perichondral Approach (M-TAPA) And External Oblique Intercostal Plane Block (EOIPB) in Patients Undergoing Laparoscopic Cholecystectomy Surgeries (LC)

for Post Operative Pain

Sponsor: Kasr El Aini Hospital

Sex: All·Age: 18 - 65

Code: NCT06810206

Comparison of Serratus Posterior Superior Intercostal Plane Block and Deep Serratus Anterior Plane Block After Video-Assisted Thoracoscopic Surgery

for Postoperative Pain

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553195

Transversalis Fascia Plane Block Versus M-TAPA Block After Laparoscopic Inguinal Hernia Repair

for Transversalis Fascia Plane Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07619053

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07599787

SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery

for Rib Fracture

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553208

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07589491

SPENG Block Versus Suprascapular and Axillary Nerve Blocks for Pain After Shoulder Arthroscopy

for Postoperative Pain

Sponsor: Izmir City Hospital

Sex: All·Age: 18 - 70

Code: NCT07762417

Single vs Multiple Injection Intertransverse Process Block in Breast Cancer Surgery

for Breast Cancer

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07763756

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

Apply to this trial

Postoperative Pain and Tenesmus After Doppler-Guided Hemorrhoidal Artery Ligation With or Without Mucopexy

for Postoperative Pain

Sponsor: Ali Genc

Sex: All·Age: 18+

Code: NCT07710053

Remote Assessment of Pain and Recovery Quality After Surgery Using a Digital Form: A Pilot Study

for Remote Monitoring of Pain and Recovery Quality in the Immediate Postoperative Period Using a Digital Health Tool

Sponsor: Hospital de Base

Sex: All·Age: 18+

Code: NCT07794267

Suzetrigine for Postoperative Pain After Total Ankle Replacement

for Ankle Osteoarthritis

Sponsor: Soheil Ashkani Esfahani

Sex: All·Age: 18 - 75

Code: NCT07795827·Phase 4

Jaw Muscle Pain Post Wisdom Molar Surgery

for Post Operative Pain

1 site in Newark

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 18+

Code: NCT07094542·Phase 2

The Effectiveness of High-intensity Laser Therapy on Post-surgical Rehabilitation After Total Knee Arthroplasty

for Arthroplasty Complications

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 50 - 80

Code: NCT07568262

Impact of Preemptive Analgesia on Postoperative Pain in Orthognathic Surgery

for Post Operative Pain

Sponsor: University of Puerto Rico

Sex: All·Age: 21 - 65

Code: NCT07571252·Phase 4

Apply to this trial

Recovery With Virtual Reality for Stress and Pain

for Preoperative Anxiety

Sponsor: Region Skane

Sex: All·Age: 18+

Code: NCT07679022

Topical Magnesium Sulfate Versus Peritonsillar Bupivacaine for Post-Tonsillectomy Pain Relief in Children

for Post-tonsillectomy Pain

Sponsor: Assiut University

Sex: All·Age: 8 - 15

Code: NCT07760207·Phase 4

PCDD Generation 1 Oral Liquid Acetaminophen Delivery Evaluation

for Pain Management

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07765238

Intravenous Dexamethasone Added to Dexmedetomidine After Superior Trunk Block

for Postoperative Pain

Sponsor: Gaziantep City Hospital

Sex: All·Age: 18 - 65

Code: NCT07795281·Phase 4

Analgesic Outcomes of Ultrasound-Guided QLB vs TAP Block in Midline Laparotomy

for Postoperative Pain

Sponsor: Sheikh Zayed Medical College

Sex: All·Age: 18 - 65

Code: NCT07796828

The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery

for Postoperative Pain

Sponsor: Fenerbahce University

Sex: All·Age: 18+

Code: NCT07771751

Sphenopalatine Ganglion Block for Pain Relief After Pediatric Adenotonsillectomy

for Postoperative Pain

Sponsor: Vinícius C Quintão, MD, MSc, PhD

Sex: All·Age: 2 - 13

Code: NCT07793617·Phase 4

Combined Popliteal and Adductor Canal Blocks for Postoperative Analgesia in Children With Cerebral Palsy

for Cerebral Palsy

Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital

Sex: All·Age: 3 - 18

Code: NCT07801365

SPIP vs ESP Block in Cardiac Surgery

for Cardiac Surgery

Sponsor: Ondokuz Mayıs University

Sex: All·Age: 18 - 80

Code: NCT07780773

Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery

for Pain, Postoperative

Sponsor: Konya City Hospital

Sex: All·Age: 18+

Code: NCT07720791·Phase 4

SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients

for Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine

Sponsor: juan jose valero quintero,MD

Sex: All·Age: 18 - 100

Code: NCT07693517

Timing of Serratus Anterior Plane Block in Mastectomy Surgery

for Quality of Recovery After Mastectomy

Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Sex: Female·Age: 18+

Code: NCT07661212

Effectiveness of WeChat-Supported Neck Rehabilitation Exercises on Early Recovery After Thyroidectomy

for Thyroid Diseases

Sponsor: Shanghai 6th People's Hospital

Sex: All·Age: 18 - 60

Code: NCT07707401

Apply to this trial

Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control

for Postoperative Pain

Sponsor: Hospital de Clinicas de Porto Alegre

Sex: All·Age: 18+

Code: NCT07763249

Impact of Sodium Hypochlorite Irrigation at Different Concentrations, With and Without Cryotherapy, on Post Operative Pain in Permanent Mandibular Molar Teeth.

for Postoperative Pain

Sponsor: Future University in Egypt

Sex: All·Age: 15 - 40·Accepts healthy volunteers

Code: NCT07771816

Magnesium Sulfate With Standard Combined Costoclavicular-Suprascapular Block for Pain Relief After Shoulder Arthroscopy.

for Shoulder Arthroscopy

Sponsor: Assiut University

Sex: All·Age: 18 - 50

Code: NCT07798115

PENG Block Versus Intrathecal Morphine for Early Postoperative Recovery After Total Hip Arthroplasty

for Postoperative Pain

Sponsor: Erzincan Binali Yildirim Universitesi

Sex: All·Age: 18 - 85

Code: NCT07803133

Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds

for Spinal Disease

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06792474·Phase 4

Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery

for Fascia Iliaca Block

Sponsor: Peking University First Hospital

Sex: All·Age: 18+

Code: NCT07643792·Phase 4

Assessment of Post-Operative Pain After Using Cryotherapy and Dexamethasone

for Post Operative Pain

Sponsor: Suez Canal University

Sex: All·Age: 20 - 50

Code: NCT07738302

Effect of Local Anesthetic Infiltration for Postoperative Pain Control in Laparoscopic Abdominal Surgery: A Prospective Randomized Study

for Postoperative Pain

Sponsor: Allied Hospital Faisalabad

Sex: All·Age: 18 - 60

Code: NCT07747584

FICB for Hip Fracture Pain in Elderly

for Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures)

Sponsor: RenJi Hospital

Sex: All·Age: 65+

Code: NCT07762846

Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal Block in Patients Undergoing Breast Cancer Surgery

for Breast Cancer

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07536867

Analgesic Efficacy of Intertransverse Process Block Versus Erector Spinae Plane Block

for Robotic Colorectal Surgery

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07583602

Parasternal Intercostal Plane Catheter for Pain Control After CABG Surgery

for Bypass Surgery

Sponsor: Koc University Hospital

Sex: All·Age: 18+

Code: NCT07759570

Recto-Intercostal Fascial Plane and External Oblique Intercostal Blocks for Pain in Laparoscopic Cholecystectomyin Laparoscopic Cholecystectomy

for Postoperative Pain

Sponsor: Ankara Etlik City Hospital

Sex: All·Age: 18 - 75

Code: NCT07777172

Comparison of TAP Block and Umbilical Paramedian Linea Semilunaris Block in Pediatric Laparoscopic Surgery

for Postoperative Pain

Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Sex: All·Age: 1 - 18

Code: NCT07801794

Pericapsular Nerve Group Block Versus Intrathecal Morphine for Pain After Hip Surgery

for Hip Arthroplasty, Total

Sponsor: Selcuk University

Sex: All·Age: 18 - 65

Code: NCT07784192

Apply to this trial

Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Cardiac Surgery

for Cardiac Surgery

Sponsor: Burak Çilingir

Sex: All·Age: 18 - 80

Code: NCT07785323

Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine Surgery

for Lumbar Disc Herniation

Sponsor: Vezirköprü State Hospital

Sex: All·Age: 18 - 65

Code: NCT07750418

Enhanced Recovery Protocol Compliance and Quality of Recovery After Cesarean Delivery

for Cesarean Section

Sponsor: Bursa City Hospital

Sex: Female·Age: 18+

Code: NCT07790471

Apply to this trial

One-level and Bi-level ESPB Application in Patients Undergoing Breast Surgery

for Pain, Postoperative

Sponsor: Atatürk Chest Diseases and Chest Surgery Training and Research Hospital

Sex: Female·Age: 18 - 80

Code: NCT07747623

Impact of Video-Based Patient Education on Physician Trust, Pain, and Anxiety in Laparoscopic Cholecystectomy

for Postoperative Pain

Sponsor: Sanliurfa Education and Research Hospital

Sex: All·Age: 18 - 65

Code: NCT07767344

Apply to this trial

Local Anesthetic Infiltration for Pain Control After Orthopedic Wide Excision

for Wide Excision

Sponsor: Seoul National University Hospital

Sex: All·Age: 19+

Code: NCT07753629

Transverse vs. Longitudinal Serratus Anterior Plane Block in Breast Surgery

for Fascial Plane Block

Sponsor: Ankara Etlik City Hospital

Sex: All·Age: 18 - 65

Code: NCT07739277

Apply to this trial

Ultrasound-Guided PECS II Block for Permanent Pacemaker Implantation

for Cardiac Pacing

Sponsor: ferdi gülaştı

Sex: All·Age: 18+

Code: NCT07739407

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Postoperative pain clinical trials — common questions

Are postoperative pain clinical trials free to join?

Yes. Participating in a postoperative pain clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a postoperative pain clinical trial?

Each postoperative pain study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a postoperative pain trial near me?

Use the location controls above. We'll show recruiting postoperative pain trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many postoperative pain trials are recruiting right now?

We're currently tracking roughly 88 recruiting postoperative pain trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Postoperative pain trials by city

Boston, MA Los Angeles, CA Chicago, IL San Francisco, CA Ann Arbor, MI Cleveland, OH

Related specialties

Pain management