Postoperative pain Clinical Trials

Recruiting postoperative pain studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat postoperative pain. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting postoperative pain studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting postoperative pain trials

Within

Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery

for Postoperative Pain

Sponsor: University of Alexandria

Sex: All·Age: 18 - 65

Code: NCT04110132

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

for Distal Radius Fracture

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05318729

Study of QL Analgesic Response and Extent

for Acute Pain

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07566312·Phase 4

Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME)

for Postoperative Pain

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07624006·Phase 4

Intertransverse Process Block Versus Subcostal Transversus Abdominis Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591129

Intertransverse Process Block Versus External Oblique Intercostal Plane Block After Laparoscopic Sleeve Gastrectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07591116

Comparison of Serratus Posterior Superior Intercostal Plane Block and Deep Serratus Anterior Plane Block After Video-Assisted Thoracoscopic Surgery

for Postoperative Pain

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553195

Transversalis Fascia Plane Block Versus M-TAPA Block After Laparoscopic Inguinal Hernia Repair

for Transversalis Fascia Plane Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07619053

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07599787

SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery

for Rib Fracture

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07553208

Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy

for Intertransverse Process Block

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07589491

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

Apply to this trial

Postoperative Pain and Tenesmus After Doppler-Guided Hemorrhoidal Artery Ligation With or Without Mucopexy

for Postoperative Pain

Sponsor: Ali Genc

Sex: All·Age: 18+

Code: NCT07710053

Jaw Muscle Pain Post Wisdom Molar Surgery

for Post Operative Pain

1 site in Newark

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 18+

Code: NCT07094542·Phase 2

The Effectiveness of High-intensity Laser Therapy on Post-surgical Rehabilitation After Total Knee Arthroplasty

for Arthroplasty Complications

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 50 - 80

Code: NCT07568262

Recovery With Virtual Reality for Stress and Pain

for Preoperative Anxiety

Sponsor: Region Skane

Sex: All·Age: 18+

Code: NCT07679022

SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients

for Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine

Sponsor: juan jose valero quintero,MD

Sex: All·Age: 18 - 100

Code: NCT07693517

Timing of Serratus Anterior Plane Block in Mastectomy Surgery

for Quality of Recovery After Mastectomy

Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Sex: Female·Age: 18+

Code: NCT07661212

Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds

for Spinal Disease

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06792474·Phase 4

Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal Block in Patients Undergoing Breast Cancer Surgery

for Breast Cancer

Sponsor: Antalya City Hospital

Sex: Female·Age: 18 - 65

Code: NCT07536867

Analgesic Efficacy of Intertransverse Process Block Versus Erector Spinae Plane Block

for Robotic Colorectal Surgery

Sponsor: Antalya City Hospital

Sex: All·Age: 18 - 65

Code: NCT07583602

Exparel and Dexamethasone

for Postoperative Pain

Sponsor: Duke University

Sex: All·Age: 18 - 80

Code: NCT07614802·Phase 4

Timing Of Midazolam İn Children Undergoing Adenotonsillectomy: Effects On Stress, Cortisol, And Recovery

for Adenotonsillectomy

Sponsor: Erzurum City Hospital

Sex: All·Age: 3 - 10

Code: NCT07622641

Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

for Postoperative Pain

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07644923·Phase 4

Oral Nifedipine Versus Placebo for Pain and Healing After Hemorrhoidectomy

for Hemorrhoids

Sponsor: Sana'a University

Sex: All·Age: 18 - 65

Code: NCT07659665·Phase 4

Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy

for Postoperative Pain

Sponsor: Assiut University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07670052·Phase 4

ESP Blocks for Posterior Spinal Fusion

for Postoperative Pain

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07228039·Phase 4

Psilocybin After Trauma Surgery for Pain

for Pain Management

1 site in Pittsburgh

Sponsor: Trent Emerick

Sex: All·Age: 25 - 65

Code: NCT07406828·Phase 1

Effect of a Herbal Intracanal Medication On Postoperative Pain And Flare up Incidence In Non Surgical Root Canal Retreatment

for Postoperative Pain

Sponsor: Minia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07578311

Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery

for Older Adults

Sponsor: Peking University First Hospital

Sex: All·Age: 55+

Code: NCT07643792·Phase 4

Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia

for Pain, Postoperative

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07689162·Phase 2

Postoperative Analgesic Efficacy of ACB+iPACK vs FTB+Selective Tibial+Obturator Blocks in ACL Reconstruction

for Anterior Cruciate Ligament Injuries

Sponsor: Da Nang Hospital

Sex: All·Age: 16+

Code: NCT07702552

Efficacy of Adding Intrathecal Morphine to Erector Spinae Plane Block for Postoperative Analgesia After Midline Laparotomy

for Postoperative Pain

Sponsor: Sohag University

Sex: All·Age: 18 - 60

Code: NCT07720739

Apply to this trial

Clinical Pharmacist-Led Perioperative Pain Management in Orthopedic Surgery: An Effectiveness Evaluation

for Postoperative Pain

Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Sex: All·Age: 18 - 99

Code: NCT07688486

QLESP Block for Pain Control in Robotic Partial Nephrectomy

for Renal Cell Carcinoma (Kidney Cancer)

Sponsor: Huazhong University of Science and Technology

Sex: All·Age: 18 - 80

Code: NCT07704970

Quadroiliac Plane Block for Analgesia After Renal Transplantation

for Postoperative Pain

Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Sex: Female·Age: 18 - 80

Code: NCT07716566

Effects of Intraarticular Tramadol and Tramadol-Dexamethasone on Postoperative Pain After Knee Arthroscopy

for Knee Arthroscopy

Sponsor: Arzu Esen Tekeli

Sex: All·Age: 18 - 65

Code: NCT07064993·Phase 4

FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy

for Pulmonary Dysfunction

1 site in New Brunswick

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 40+

Code: NCT07637370

Injection Site in Ultrasound-Guided Interscalene Block for Shoulder Arthroscopy

for Shoulder Arthroscopy

Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Sex: All·Age: 18+

Code: NCT07695025

Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery

for Pain, Postoperative

Sponsor: Seoul National University Hospital

Sex: All·Age: 19 - 79

Code: NCT07699744·Phase 4

Lateral QL Block vs Intrathecal Morphine for Cesarean Section

for Anesthesia

Sponsor: Ondokuz Mayıs University

Sex: Female·Age: 18 - 45

Code: NCT07712783

Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery

for Pain, Postoperative

Sponsor: Konya City Hospital

Sex: All·Age: 18+

Code: NCT07720791·Phase 4

Effectiveness of WeChat-Supported Neck Rehabilitation Exercises on Early Recovery After Thyroidectomy

for Thyroid Diseases

Sponsor: Shanghai 6th People's Hospital

Sex: All·Age: 18 - 60

Code: NCT07707401

Apply to this trial

Virtual Reality and Cryotherapy for Postoperative Pain and Anxiety After Cesarean Section

for Postoperative Pain

Sponsor: Shahid Beheshti University of Medical Sciences

Sex: Female·Age: 18 - 45

Code: NCT07696949

Impact of RADA16 Use on Outcomes Following Tonsillectomy in Children

for Postoperative Pain

2 sites incl. Livingston

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 3 - 17

Code: NCT07188779·Phase 2

Apply to this trial

ANI-Guided Anesthetic Desflurane Consumption

for Postoperative Pain

Sponsor: Wonkwang University Hospital

Sex: All·Age: 19 - 65

Code: NCT06982209

Apply to this trial

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

for Surgical Stress Response

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07464860

Apply to this trial

Phase 3 Bunionectomy Study

for Postoperative Pain

1 site in Salt Lake City

Sponsor: Cali Pharmaceuticals LLC

Sex: All·Age: 18 - 75

Code: NCT07490496·Phase 3

Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)

for Postoperative Pain

1 site in Irvine

Sponsor: Alexandre P. Joosten

Sex: All·Age: 18+

Code: NCT07565870·Phase 3

Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery

for Pelvic Organ Prolapse (POP)

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: Female·Age: 18+

Code: NCT07600697·Phase 4

Comparison of Intraperitoneal Bupivacaine and Saline Irrigation for Pain Relief After Laparoscopic Cholecystectomy

for Postoperative Pain

Sponsor: Wah Medical college , POF hospital

Sex: All·Age: 18 - 60

Code: NCT07650760·Phase 4

Apply to this trial

Investigating the Analgesic Efficacy and Ease of Perfomance of Modified Throracoabdominal Plane Block and Comparing it With Erector Spinea Plane Block in Laparacopic Sleeve Gasterctomy Surgeries

for Postoperative Pain

Sponsor: Cairo University

Sex: All·Age: 18 - 60

Code: NCT07654556

The Effect of Pericapsular Nerve Group Block With Different Local Anesthetic Volumes

for Pericapsuler Nerve Group Block

Sponsor: Selcuk University

Sex: All·Age: 18 - 65

Code: NCT07666737

SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery

for Postoperative Pain

Sponsor: Engin Çetin

Sex: Female·Age: 18 - 65

Code: NCT07674836

Rectointercostal Plane Block (RICPB) for Laparoscopic Cholecystectomy

for Cholelithiasis

Sponsor: Koç University

Sex: All·Age: 18 - 65

Code: NCT07676552

ASPB-PIPB Combination in Cardiac Surgery

for Postoperative Pain

Sponsor: Sisli Hamidiye Etfal Training and Research Hospital

Sex: All·Age: 18+

Code: NCT07716943

VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

for ACL

1 site in New York

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06456268

Apply to this trial

Erector Spinae Plane Block Versus External Oblique Intercostal Plane Block for Analgesia in Open Cholecystectomy

for Cholecystectomy

Sponsor: Sohag University

Sex: All·Age: 18 - 65

Code: NCT07533279

Suzetrigine for Opioid-Free Recovery After Cesarean Delivery

for Cesarean Delivery

1 site in Austin

Sponsor: University of Texas at Austin

Sex: Female·Age: 18+

Code: NCT07534709·Phase 4

Methadone Perception Survey Study

for Pain, Postoperative

Sponsor: Ashley Smith

Sex: All·Age: All ages

Code: NCT07537608

Postoperative pain clinical trials — common questions

Are postoperative pain clinical trials free to join?

Yes. Participating in a postoperative pain clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a postoperative pain clinical trial?

Each postoperative pain study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a postoperative pain trial near me?

Use the location controls above. We'll show recruiting postoperative pain trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many postoperative pain trials are recruiting right now?

We're currently tracking roughly 88 recruiting postoperative pain trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Postoperative pain trials by city

Boston, MA Los Angeles, CA Chicago, IL San Francisco, CA Ann Arbor, MI Cleveland, OH Irvine, CA Maywood, IL

Related specialties

Pain management