Traumatic brain injury (TBI) Clinical Trials

Recruiting traumatic brain injury (tbi) studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat traumatic brain injury (tbi). Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting traumatic brain injury (tbi) studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting traumatic brain injury (tbi) trials

Within

Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury

for Traumatic Brain Injury

1 site in Houston

Sponsor: Healing Hope International

Sex: All·Age: 6 - 75

Code: NCT07326059

Sodium Lactate in Severe TBI

for Traumatic Brain Injury

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06701760·Phase 2

Paired VNS For TBI Rehabilitation

for Traumatic Brain Injury

Sponsor: Stony Brook University

Sex: All·Age: 22 - 80

Code: NCT07719829

Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 site in Fort Hood

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07327567

Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model

for Traumatic Brain Injury

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 2+

Code: NCT06193382

hCG Treatment for Rehabilitation From a TBI

for Traumatic Brain Injury

1 site in Madison

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18 - 65

Code: NCT07557615·EARLY_Phase 1

Evaluating Huddles as a Novel Approach to Improving Concussion Safety

for Mild Traumatic Brain Injury

Sponsor: Seattle Children's Hospital

Sex: All·Age: 9+·Accepts healthy volunteers

Code: NCT06864611

PASTRAMI : Patient-specific Statistics for Microstructure-augmented Connectomics

for Traumatic Brain Injury

Sponsor: Rennes University Hospital

Sex: All·Age: 18 - 60

Code: NCT07527949

Examining the Efficacy of the Man Therapy Platform in Reducing Problematic Anger Among Military Service Members With and Without a TBI History

for Mild Traumatic Brain Injury (mTBI)

1 site in Colorado Springs

Sponsor: University of Colorado, Denver

Sex: Male·Age: 18+

Code: NCT07604701

Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury

for Brain Concussion

Sponsor: Molly Cairncross

Sex: All·Age: 12 - 18

Code: NCT07698015

Modulating Inflammation in Neuro-Trauma

for Traumatic Brain Injury

2 sites in San Antonio

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18 - 75

Code: NCT07510074

Scale-Up Evaluation Trial of the Diabetes Prevention Program to Improve Obesity and Cardiometabolic Health After Traumatic Brain Injury

for Traumatic Brain Injury

1 site in Dallas

Sponsor: Baylor Research Institute

Sex: All·Age: 18 - 80

Code: NCT07648901

Clinical Feasibility & Validation of the Augmented Reality GlenxRose Acquired Brain Injury Rehabilitation Programs

for Acquired Brain Injury

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT05897593

Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI)

for Traumatic Brain Injury

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07038889

Comparing Approaches to Helping People With Chronic Traumatic Brain Injury Manage Their Health Care

for Traumatic Brain Injury

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07483528

Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

for Critical Illness

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 1 Day - 17

Code: NCT07613918

Promoting Neuroplastic Changes of Patients With TBI

for Traumatic Brain Injury

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 30 - 85

Code: NCT06465290

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Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials

for Traumatic Brain Injury

1 site in Philadelphia

Sponsor: Ramon Diaz-Arrastia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06963775

A Pilot Study of Home-Based Rhythmic Auditory Stimulation to Evaluate Mobility, Balance, and Patient-Reported Outcomes After Traumatic Brain Injury

for Traumatic Brain Injury

1 site in Englewood

Sponsor: Craig Hospital

Sex: All·Age: 18+

Code: NCT07702513

Home-based Vision Rehabilitation Guided by Brain Imaging

for Visual Field Defect

1 site in Washington D.C.

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT07635329

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BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence

for Brain Injuries, Acute

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 16+

Code: NCT07636213

TRACK-TBI Precision Medicine Part 3 - Option II

for Traumatic Brain Injury

2 sites incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 65

Code: NCT06790095·Phase 2

Vagus Nerve Stimulation in Patients in Comatose State

for Traumatic Brain Injury

1 site in Stony Brook

Sponsor: Sima Mofakham

Sex: All·Age: 18+

Code: NCT07719595

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Treating Traumatic Brain Injury With Transcranial Direct Current Stimulation

for Traumatic Brain Injury

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06989970

Emotional Awareness Therapy Study

for Traumatic Brain Injury

1 site in Edison

Sponsor: Hackensack Meridian Health

Sex: All·Age: 18+

Code: NCT07624825

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Ketamine in Severe Traumatic Brain Injury

for Traumatic Brain Injury

2 sites in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT06062628·EARLY_Phase 1

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Neuromodulation and fMRI in Neurodegenerative Diseases Study

for Mild Cognitive Impairment

Sponsor: Sunnybrook Health Sciences Centre

Sex: All·Age: 25+·Accepts healthy volunteers

Code: NCT06873750

Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy

for Traumatic Brain Injury

Sponsor: Healing Hope International

Sex: All·Age: 4 - 80

Code: NCT07521384

Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury

for Mild Traumatic Brain Injury

3 sites incl. Indianapolis

Sponsor: Hackensack Meridian Health

Sex: All·Age: 18+

Code: NCT07436754

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Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II

for Traumatic Brain Injury

Sponsor: Maastricht University Medical Center

Sex: All·Age: 18+

Code: NCT07287358

Fareon Open Label Device Clinical Trial

for Cognitive Dysfunction

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 16+

Code: NCT07600320

Carbon Dioxide Administration and Brain Waste Clearance

for Traumatic Brain Injury

1 site in Albuquerque

Sponsor: Andrew Mayer

Sex: All·Age: 18 - 82·Accepts healthy volunteers

Code: NCT07357090

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Implementation of TBI-RECOVER in Substance Use Treatment

for Traumatic Brain Injury

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT07215221

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Music Therapy for Comatose Brain Injured Patients

for Traumatic Brain Injury

2 sites in Youngstown

Sponsor: Mercy Health Ohio

Sex: All·Age: 18+

Code: NCT07544602

Improving Cognitive Rehabilitation Outcomes

for Mild Traumatic Brain Injury

2 sites incl. San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07055633

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Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis

for Stroke

1 site in Pomona

Sponsor: Casa Colina Hospital and Centers for Healthcare

Sex: All·Age: 18 - 80

Code: NCT07492602

Regional Ventilation Evaluation During Neuro-injury Weaning Study

for Acute Brain Injury

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07067671

Improving Speech in Noise Using Noninvasive Stimulation

for Traumatic Brain Injury

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 25 - 55·Accepts healthy volunteers

Code: NCT07176936

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Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

for PTSD

1 site in Strongsville

Sponsor: Reset Medical and Wellness Center

Sex: All·Age: 18+

Code: NCT07473505

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Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

for Persistent Post Concussion Syndrome

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 65

Code: NCT07246993

Apply to this trial

Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

for PTSD

1 site in Fort Hood

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18+

Code: NCT07351305

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TBI- Efficacy of Steroids in Acute Vasogenic Edema

for Traumatic Brain Injury

Sponsor: Meditech Foundation

Sex: All·Age: 18 - 70

Code: NCT07358312

Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)

for Sleep Architecture

1 site in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18 - 60

Code: NCT07385105

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Multicenter Early Intervention Study in Adults With Complaints After Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

Sponsor: University Medical Center Groningen

Sex: All·Age: 18 - 70

Code: NCT07341074

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A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

for Traumatic Brain Injury

12 sites incl. Sacramento

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07455136

Apply to this trial

Remote Stimulation and Training to Advance Recovery From TBI in Seniors

for Traumatic Brain Injury

1 site in Minneapolis

Sponsor: Minneapolis Veterans Affairs Medical Center

Sex: All·Age: 65+

Code: NCT07332299

Apply to this trial

Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI)

for Traumatic Brain Injury

1 site in San Antonio

Sponsor: The Geneva Foundation

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT07338383

Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for TBI

for Traumatic Brain Injury

Sponsor: The Foundation for Orthopaedics and Regenerative Medicine

Sex: All·Age: All ages

Code: NCT05018832·Phase 1

Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury

for Traumatic Brain Injury

Sponsor: Friedhelm Hummel

Sex: All·Age: 18+

Code: NCT07271524

Reliability and Validity of the PReFS

for Neurologic Disorders

1 site in Waco

Sponsor: Baylor University

Sex: All·Age: 18+

Code: NCT07280923

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Protein Intake Dosage on the Prognosis of Neurocritical Patients

for Neurocritical Conditions

Sponsor: Wenshan City People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07295301

tPBM in Older Adults With Traumatic Brain Injury

for Traumatic Brain Injury

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 55 - 85

Code: NCT06956404

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Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments

for Stroke

Sponsor: Motion Informatics LTD

Sex: All·Age: 18+

Code: NCT07404761

Apply to this trial

Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07356167

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Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments

for Traumatic Brain Injury

Sponsor: Pôle Saint Hélier

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07230002

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Hypnosis and Attention in Patients With a Neurological Disease (Stroke, Traumatic Brain Injury and Multiple Sclerosis)

for Stroke

Sponsor: Luzerner Kantonsspital

Sex: All·Age: 18+

Code: NCT07256704

Apply to this trial

Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

for Mild Traumatic Brain Injury

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 20 - 85·Accepts healthy volunteers

Code: NCT07044596

Apply to this trial

Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

for Wound Closure

1 site in Lansing

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07225101·Phase 4

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An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)

for Traumatic Brain Injury

Sponsor: University of Nottingham

Sex: All·Age: 18 - 60

Code: NCT07120373

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Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations

for Stroke

Sponsor: University Hospital, Ghent

Sex: All·Age: All ages

Code: NCT07237386

Apply to this trial

Traumatic brain injury (TBI) clinical trials — common questions

Are traumatic brain injury (tbi) clinical trials free to join?

Yes. Participating in a traumatic brain injury (tbi) clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a traumatic brain injury (tbi) clinical trial?

Each traumatic brain injury (tbi) study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a traumatic brain injury (tbi) trial near me?

Use the location controls above. We'll show recruiting traumatic brain injury (tbi) trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many traumatic brain injury (tbi) trials are recruiting right now?

We're currently tracking roughly 135 recruiting traumatic brain injury (tbi) trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Traumatic brain injury (TBI) trials by city

Chicago, IL Boston, MA Gainesville, FL Miami, FL San Diego, CA San Francisco, CA Indianapolis, IN Madison, WI Tampa, FL Birmingham, AL Cincinnati, OH Englewood, CO

Related specialties

Neurology Brain disorders