Study of DONQ52 in Active Celiac Disease
for Celiac Disease
Drug: DONQ52
Sites in Boston +57 more locations
Sponsor: Chugai Pharmaceutical
Sex: All·Age: 18 - 75
Code: NCT07239336·Phase 2·Recruiting·Listed Nov 2025
Gastroenterology Clinical Trials in Boston, MA
As of August 2026, 40 paid clinical trials are recruiting for Gastroenterology in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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40 clinical trials for Gastroenterology
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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
for Ulcerative Colitis
Drug: Duvakitug
Sites in Boston, Worcester +116 more locations
Sponsor: Sanofi
Sex: All·Age: 16 - 80
Code: NCT07184996·Phase 3·Recruiting·Listed Sep 2025
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
for Ulcerative Colitis
Drug: LY4268989
Sites in Boston +39 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 80
Code: NCT07186101·Phase 2·Recruiting·Listed Sep 2025
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
for Crohn's Disease
Drug: Tulisokibart
Sites in Boston +70 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 16 - 80
Code: NCT06430801·Phase 3·Recruiting·Listed May 2024
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
for Ulcerative Colitis
Sites in Boston +25 more locations
Sponsor: Spyre Therapeutics, Inc.
Sex: All·Age: 18 - 75
Code: NCT07012395·Phase 2·Recruiting·Listed Jun 2025
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
for Crohn's Disease
Sites in Boston +14 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 2 - 17
Code: NCT05509777·Phase 3·Recruiting·Listed Aug 2022
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
for Ulcerative Colitis
Sites in Boston, Waltham +9 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 2 - 19
Code: NCT04844606·Phase 3·Recruiting·Listed Apr 2021
Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
for Crohn's Disease
Drug: Upadacitinib
Sites in Boston +11 more locations
Sponsor: AbbVie
Sex: All·Age: 2 - 17
Code: NCT06332534·Phase 3·Recruiting·Listed Mar 2024
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
for Ulcerative Colitis
Sites in Boston +19 more locations
Sponsor: Pfizer
Sex: All·Age: 12 - 17
Code: NCT05287126·Phase 2·Recruiting·Listed Mar 2022
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
for Crohn's Disease
Drug: Guselkumab
Sites in Boston +11 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 2 - 17
Code: NCT05923073·Phase 3·Recruiting·Listed Jun 2023
A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
for Crohn's Disease
Drug: Risankizumab
Sites in Boston +10 more locations
Sponsor: AbbVie
Sex: All·Age: 2 - 17
Code: NCT05995353·Phase 3·Recruiting·Listed Aug 2023
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis
for Ulcerative Colitis
Sites in Boston +20 more locations
Sponsor: Sanofi
Sex: All·Age: 18 - 75
Code: NCT06975722·Phase 2·Recruiting·Listed May 2025
A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease
for Crohn's Disease
Sites in Boston +19 more locations
Sponsor: Sanofi
Sex: All·Age: 18 - 75
Code: NCT06958536·Phase 2·Recruiting·Listed May 2025
Low Dose IL-2 for the Treatment of Crohn's Disease
for Crohn Disease
Sites in Boston +2 more locations
Sponsor: Boston Children's Hospital
Sex: All·Age: 12 - 80
Code: NCT04263831·Phase 1, Phase 2·Recruiting·Listed Feb 2020
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
for Autoimmune Disease
Drug: Nivolumab
Sites in Boston +40 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT03816345·Phase 1·Recruiting·Listed Jan 2019
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
for Cancer Risk
1 location in Boston
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: All ages·Accepts healthy volunteers
Code: NCT05463796·Recruiting·Listed Jul 2022
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
for Carcinoma, Hepatocellular
Sites in Boston +32 more locations
Sponsor: VA Office of Research and Development
Sex: All·Age: 18 - 75
Code: NCT05486572·Recruiting·Listed Aug 2022
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
for Crohn Disease
Sites in Boston +20 more locations
Sponsor: Connecticut Children's Medical Center
Sex: All·Age: 6 - 17
Code: NCT05781152·Phase 4·Recruiting·Listed Mar 2023
Gluten Technology and Education for Celiac Health
for Celiac Disease
Sites in Boston +3 more locations
Sponsor: Columbia University
Sex: All·Age: 18 - 75
Code: NCT06059716·Recruiting·Listed Sep 2023
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
for Obesity
Sites in Boston +1 more location
Sponsor: Pichamol Jirapinyo, MD, MPH
Sex: All·Age: 18+
Code: NCT06138821·Recruiting·Listed Nov 2023
GpCRC Pediatric Gastroparesis Registry 2
for Gastroparesis
Sites in Boston +5 more locations
Sponsor: Johns Hopkins Bloomberg School of Public Health
Sex: All·Age: 8 - 25
Code: NCT05981300·Recruiting·Listed Aug 2023
Celiac Disease Genomic Environmental Microbiome and Metabolomic Study
for Celiac Disease
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: Up to 6 Months
Code: NCT02061306·Recruiting·Listed Feb 2014
A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule
for Lynch Syndrome
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18 - 75·Accepts healthy volunteers
Code: NCT07219537·Recruiting·Listed Oct 2025
Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms
for Gastroparesis
Sites in Boston +4 more locations
Sponsor: Johns Hopkins Bloomberg School of Public Health
Sex: All·Age: 18 - 85·Accepts healthy volunteers
Code: NCT04661215·Recruiting·Listed Dec 2020
Gastroparesis Registry 4
for Gastroparesis
Sites in Boston +5 more locations
Sponsor: Johns Hopkins Bloomberg School of Public Health
Sex: All·Age: 18 - 85
Code: NCT05846802·Recruiting·Listed May 2023
Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
for Chronic Pancreatitis
Sites in Boston +21 more locations
Sponsor: M.D. Anderson Cancer Center
Sex: All·Age: Up to 17
Code: NCT06651580·Recruiting·Listed Oct 2024
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
for Cirrhosis, Liver
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18+
Code: NCT06525623·Recruiting·Listed Jul 2024
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
for Non-Alcoholic Fatty Liver Disease
2 locations in Boston
Sponsor: Brigham and Women's Hospital
Sex: All·Age: 18+
Code: NCT05728697·Recruiting·Listed Feb 2023
Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
for Ulcerative Colitis
Sites in Boston +11 more locations
Sponsor: Northwestern University
Sex: All·Age: 18 - 85
Code: NCT05987852·Recruiting·Listed Aug 2023
Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
for Barretts Esophagus With Dysplasia
Sites in Boston +22 more locations
Sponsor: University of Colorado, Denver
Sex: All·Age: 18 - 89
Code: NCT05753748·Recruiting·Listed Mar 2023
Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility
for Inflammatory Bowel Diseases
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 14+·Accepts healthy volunteers
Code: NCT05332639·Recruiting·Listed Apr 2022
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
for Inflammatory Bowel Disease
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 13 - 20·Accepts healthy volunteers
Code: NCT04508088·Recruiting·Listed Aug 2020
Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
for Crohn Disease
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18 - 75·Accepts healthy volunteers
Code: NCT07033208·Recruiting·Listed Jun 2025
Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus
for Barrett Esophagus
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18+
Code: NCT03830801·Recruiting·Listed Feb 2019
Immune Responses to Gluten
for Celiac Disease
Sites in Boston +1 more location
Sponsor: Boston Children's Hospital
Sex: All·Age: 2 - 101·Accepts healthy volunteers
Code: NCT05209568·Recruiting·Listed Jan 2022
Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk
for Liver Fibroses
Sites in Boston +1 more location
Sponsor: Raymond Chung
Sex: All·Age: 18+
Code: NCT05028829·Phase 2·Recruiting·Listed Aug 2021
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
for Cirrhosis
2 locations in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18+
Code: NCT05205954·Recruiting·Listed Jan 2022
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
for Liver Disease Chronic
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18+
Code: NCT05998330·Recruiting·Listed Aug 2023
Intermittent Fasting for NAFLD in Adults
for Fatty Liver
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18+
Code: NCT04899102·Recruiting·Listed May 2021
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy
for Inflammatory Bowel Disease
1 location in Boston
Sponsor: Boston Children's Hospital
Sex: All·Age: 5 - 25
Code: NCT04331639·Recruiting·Listed Apr 2020
Top Research Study Locations in Boston
Researchers run research studies in Boston, MA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Massachusetts General Hospital | Breast Cancer, Advanced Solid Tumor, Heart Failure | 694 |
| Brigham and Women's Hospital | Obesity, Breast Cancer, Prostate Cancer | 350 |
| Dana-Farber Cancer Institute | Breast Cancer, Acute Myeloid Leukemia, Multiple Myeloma | 343 |
| Beth Israel Deaconess Medical Center | Multiple Myeloma, Lymphoma, Acute Myeloid Leukemia | 263 |
| Boston Children's Hospital | Congenital Heart Disease, Cystic Fibrosis, Sickle Cell Disease | 259 |
| Dana Farber Cancer Institute | Breast Cancer, Ovarian Cancer, Prostate Cancer | 217 |
| Tufts Medical Center | Heart Failure, Acute Myeloid Leukemia, Acute Respiratory Distress Syndrome | 111 |
| Boston Medical Center | Amblyopia, Alpha1-Antitrypsin Deficiency, Anatomic Stage II Breast Cancer AJCC v8 | 95 |
| Massachusetts General Hospital Cancer Center | Breast Cancer, Coping Skills, B Acute Lymphoblastic Leukemia | 51 |
| VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA | Chronic Obstructive Pulmonary Disease, Mild Traumatic Brain Injury, Prostate Cancer | 29 |
| Brigham & Women's Hospital | Attention, Chronic Lymphocytic Leukemia, Critical Illness | 26 |
| Boston University | Obsessive-Compulsive Disorder, Adolescent Behavior Problem, Alzheimer Disease | 24 |
| Joslin Diabetes Center | Type 1 Diabetes Mellitus, Type 1 Diabetes (T1D), T1D | 22 |
| Mass General Brigham | Heart Failure, Heart Failure With Preserved Ejection Fraction, Advanced Solid Tumors | 22 |
| Northeastern University | Cognitive Change, Autism Spectrum Disorder (ASD), Healthy | 22 |
| Massachusetts Eye and Ear | Cone Rod Dystrophy, Glaucoma, Juvenile Macular Degeneration | 17 |
| Ophthalmic Consultants of Boston | Neovascular Age-related Macular Degeneration, Macular Edema Secondary to Inflammation, Age-Related Macular Degeneration | 13 |
| Adams Clinical Boston | Depressive Disorder, Major, Major Depressive Disorder, Alcohol Use Disorder | 12 |
| Brigham and Womens Hospital | Advanced Prostate Cancer, Alpha1-Antitrypsin Deficiency, Alzheimers Disease | 12 |
| Massachusetts Eye and Ear Infirmary | Laryngeal Dystonia, Stargardt Disease, Age-related Macular Degeneration | 12 |
| Clinical Trial Site | Transthyretin Amyloidosis With Cardiomyopathy, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2, Acid Lipase Deficiency | 11 |
| Mass General Hospital | Biliary Tract Cancer (BTC), PDAC - Pancreatic Ductal Adenocarcinoma, AML | 11 |
| Beth Israel Deaconess Medical Center (BIDMC) | Prostate Cancer, Advanced Melanoma, Endometrial Cancer | 11 |
| Boston Childrens Hospital | CSTB-related Disease, Crohn's Disease, Cystic Fibrosis | 10 |
| Brigham and Women's Faulkner Hospital | Multimodal Analgesia, Opioid Consumption, Postoperative, Adverse Event | 8 |
Active & Upcoming Studies in Boston (2026)
Recruiting trials in Boston grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (877 active studies)
- Early Intervention · Massachusetts General Hospital
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
Neurology & pain (218 active studies)
- Mindfulness Therapy for Chronic Pain After Intimate Partner Violence · Brigham and Women's Hospital
- Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · Brigham and Women's Hospital
Cardiovascular (189 active studies)
- Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · Brigham and Women's Hospital
- CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock · Phase 2 · Brigham and Women's Hospital
Diabetes & metabolic (97 active studies)
- Adiposity Distribution in Acute Respiratory Failure · Maurizio F. Cereda, MD
- Creating Linked Inpatient CGM for Kids · Boston Children's Hospital
Mental health & behavior (89 active studies)
- Whole Selves User Testing and Feasibility Study · Boston University
- Clinician Practice Companion to Address Youth Substance Use · Massachusetts General Hospital
Pediatric (62 active studies)
- Clinician Practice Companion to Address Youth Substance Use · Massachusetts General Hospital
- Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease · EARLY_Phase 1 · Massachusetts General Hospital
HIV / STI (33 active studies)
- Intervention to Reduce Implicit Bias in Pharmacies · Massachusetts General Hospital
- Academic Detailing to Optimize PrEP Implementation in Pediatric Primary Care Settings: ADOPT-PrEP · Boston Children's Hospital
Eye & vision (32 active studies)
- Glaucoma Drop Aids Part 2 · Boston Medical Center
- Study of Remimazolam for Cataract Surgery · Phase 4 · Fred E, Shapiro
Vaccines (15 active studies)
- Sauna for Long Covid · Massachusetts General Hospital
- A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Common conditions studied in Boston
- Breast Cancer (64 active studies)
- Prostate Cancer (41 active studies)
- Ovarian Cancer (36 active studies)
- Heart Failure (34 active studies)
- Acute Myeloid Leukemia (32 active studies)
- Advanced Solid Tumor (31 active studies)
Leading research sponsors in Boston
- Massachusetts General Hospital
- Brigham and Women's Hospital
- Boston Children's Hospital
- Dana-Farber Cancer Institute
- Beth Israel Deaconess Medical Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Boston?
There are approximately 2,887 recruiting clinical trials in Boston, Massachusetts listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Boston pay participants?
Most recruiting trials in Boston compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Boston?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Boston?
The most common conditions under active study in Boston include Breast Cancer (64), Prostate Cancer (41), Ovarian Cancer (36), Heart Failure (34), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Boston?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Boston on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Boston?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Boston?
Recruiting research sites in Boston include Massachusetts General Hospital, Brigham and Women's Hospital, Dana-Farber Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Boston right now?
The largest active categories in Boston are Cancer & tumors (877), Neurology & pain (218), Cardiovascular (189). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
Other cities in Massachusetts
Worcester, MA(208)Burlington, MA(81)Springfield, MA(74)Waltham, MA(58)Cambridge, MA(47)Belmont, MA(46)Charlestown, MA(41)Foxborough, MA(36)Newton, MA(32)Watertown, MA(30)Methuen, MA(24)Milford, MA(24)Brighton, MA(23)Peabody, MA(23)New Bedford, MA(22)Chestnut Hill, MA(18)Beverly, MA(17)Fall River, MA(14)South Weymouth, MA(14)Gloucester, MA(13)Brookline, MA(12)Bedford, MA(11)Plymouth, MA(11)Lowell, MA(9)Needham, MA(9)North Dartmouth, MA(9)Quincy, MA(9)Stoneham, MA(9)Weymouth, MA(9)Danvers, MA(8)Lexington, MA(8)Natick, MA(7)South Dartmouth, MA(7)Amherst, MA(6)Framingham, MA(6)Jamaica Plain, MA(6)Winchester, MA(6)Roslindale, MA(5)Salem, MA(5)Wellesley, MA(5)Westborough, MA(5)Andover, MA(4)Holyoke, MA(4)Malden, MA(4)Marlborough, MA(4)North Worcester, MA(4)Somerville, MA(4)Braintree, MA(3)Brockton, MA(3)Fairhaven, MA(3)Lawrence, MA(3)Pittsfield, MA(3)Shrewsbury, MA(3)West Roxbury, MA(3)Acton, MA(2)Allston, MA(2)Chelsea, MA(2)Hyannis, MA(2)Hyde Park, MA(2)Medford, MA(2)