Brain disorders Clinical Trials in Philadelphia, PA
As of September 2026, 68 paid clinical trials are recruiting for Brain disorders in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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68 clinical trials for Brain disorders
·Clear filters·A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
Strategy for Improving Stroke Treatment Response
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)
A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Diagnosing Epilepsy To EffeCT Change
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
CoMind Early Feasibility Study
A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis
KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis
Pilot/Pivotal Study of DBS+Rehab After Stroke
A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
Neuralert Stroke Monitor Trial
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures
The Neuralert Stroke Monitor Pilot Trial
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2
Parkinson's Foundation PD GENEration Genetic Registry
The Fourth Left Atrial Appendage Occlusion Study
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
PREVENT ALL ALS Study
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
Top Research Study Locations in Philadelphia
Researchers run research studies in Philadelphia, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pennsylvania | Heart Failure, Opioid Use Disorder, Colorectal Cancer | 359 |
| Children's Hospital of Philadelphia | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, Pediatric Cancer | 303 |
| Thomas Jefferson University Hospital | Anatomic Stage II Breast Cancer AJCC v8, Acute Myeloid Leukemia, Anatomic Stage I Breast Cancer AJCC v8 | 106 |
| Fox Chase Cancer Center | Breast Cancer, Cancer, Urothelial Carcinoma | 95 |
| Thomas Jefferson University | Focal Epilepsy, Advanced Melanoma, Anemia | 95 |
| Hospital of the University of Pennsylvania | Abdominal Aortic Aneurysm, Breast Cancer, Aortic Dissection | 88 |
| Temple University | Amyotrophic Lateral Sclerosis, COPD, Emphysema | 41 |
| The Children's Hospital of Philadelphia | Mitochondrial Diseases, Primary Mitochondrial Disease, 4H Syndrome | 40 |
| Temple University Hospital | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, COPD | 34 |
| University of Pennsylvania/Abramson Cancer Center | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 30 |
| Pennsylvania Hospital | Stroke, Acute, Activity Restriction, Advanced Cancer | 28 |
| Penn Presbyterian Medical Center | Heart Failure, ADHF, AV Block | 25 |
| Abramson Cancer Center of the University of Pennsylvania | Breast Cancer, Advanced Solid Tumor, Diffuse Large B Cell Lymphoma | 24 |
| Saint Christopher's Hospital for Children | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 22 |
| Jefferson Torresdale Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 21 |
| Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA | Parkinson Disease, Stress Disorders, Post-Traumatic, Advanced Urothelial Carcinoma | 19 |
| Sidney Kimmel Cancer Center at Thomas Jefferson University | Breast Cancer, Colorectal Cancer, Cancer | 15 |
| Penn Medicine | Hypertension, ALS, Allogeneic Transplantation | 14 |
| University of Pennsylvania Hospital | Chronic Lymphocytic Leukemia, Neoplasm Metastasis, Non-Hodgkin Lymphoma | 13 |
| University of Pennsylvania, Abramson Cancer Center | Advanced Solid Tumor, Biliary Tract Cancer, Breast Cancer | 13 |
| GSK Investigational Site | Asthma, Connective Tissue Diseases, Gastrointestinal Neoplasms | 12 |
| Drexel University | Autism Spectrum Disorder, Anxiety, Attention Deficit and Disruptive Behavior Disorders | 12 |
| Abramson Cancer Center at University of Pennsylvania | Cardiotoxicity, Renal Cell Carcinoma, AML, Adult | 10 |
| Childrens Hospital of Philadelphia | Suicide, Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR) | 10 |
| Thomas Jefferson University, Sidney Kimmel Cancer Center | Advanced Solid Tumor, Colorectal Cancer, Bladder Cancer | 10 |
Active & Upcoming Studies in Philadelphia (2026)
Recruiting trials in Philadelphia grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (555 active studies)
- Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First Relapse · Phase 2 · National Cancer Institute (NCI)
- A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information · Children's Oncology Group
Cardiovascular (113 active studies)
- Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial · Phase 3 · The George Washington University Biostatistics Center
- Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass-Substudy · University of Pennsylvania
Neurology & pain (106 active studies)
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
- Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease · Phase 4 · VA Office of Research and Development
Diabetes & metabolic (61 active studies)
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities · Phase 3 · Ascletis Pharma (China) Co., Limited
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
Mental health & behavior (49 active studies)
- NST-SPARK Open-Label Phase 1 STTR (IGNITE) · North Shore Therapeutics, Inc.
- Optimizing Stimulation Parameters for Electroconvulsive Therapy · University of Pennsylvania
Pediatric (47 active studies)
- Bilevel Positive Airway Pressure (BPAP) for Severe Asthma · Columbia University
- Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). · Phase 2 · BrainChild Bio, Inc
HIV / STI (28 active studies)
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy · International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Eye & vision (22 active studies)
- Penn SICCA Follow-up Study · University of Pennsylvania
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME) · Phase 1 · Genentech, Inc.
Vaccines (7 active studies)
- A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age · Phase 3 · GlaxoSmithKline
- Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older · Phase 1, Phase 2 · Sanofi
Common conditions studied in Philadelphia
- Breast Cancer (37 active studies)
- Cancer (23 active studies)
- Ovarian Cancer (23 active studies)
- Heart Failure (22 active studies)
- Prostate Cancer (21 active studies)
- Advanced Solid Tumor (19 active studies)
Leading research sponsors in Philadelphia
- University of Pennsylvania
- Abramson Cancer Center at Penn Medicine
- Children's Hospital of Philadelphia
- Thomas Jefferson University
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Philadelphia?
There are approximately 1,988 recruiting clinical trials in Philadelphia, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Philadelphia pay participants?
Most recruiting trials in Philadelphia compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Philadelphia?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Philadelphia?
The most common conditions under active study in Philadelphia include Breast Cancer (37), Cancer (23), Ovarian Cancer (23), Heart Failure (22), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Philadelphia?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Philadelphia on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Philadelphia?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Philadelphia?
Recruiting research sites in Philadelphia include University of Pennsylvania, Children's Hospital of Philadelphia, Thomas Jefferson University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Philadelphia right now?
The largest active categories in Philadelphia are Cancer & tumors (555), Cardiovascular (113), Neurology & pain (106). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.