Clinical Trials at Children's Hospital of Philadelphia
As of September 2026, 276 paid clinical trials are recruiting at Children's Hospital of Philadelphia, located at 3550 MARKET ST, 5TH FLOOR, PHILADELPHIA, PA 19104-3329, phone (215) 590-4862 in Philadelphia, Pennsylvania. Active studies at this site cover conditions such as Breast Cancer, Ovarian Cancer and Heart Failure. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Philadelphia
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).
278 clinical trials at Children's Hospital of Philadelphia
·Clear filters·A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)
A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
Pompe Disease Registry Protocol
Fabry Disease Registry & Pregnancy Sub-registry
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
Child and Adolescent Registry for Participants With Narcolepsy
A Gaucher Disease Gene Therapy Trial With FLT201
Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder
A Long-term Follow-up Study in Patients Who Received BEAM-101
A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment
A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)
REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
MEASuRE: Metreleptin Effectiveness And Safety Registry
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
Study of Olutasidenib and Temozolomide in HGG
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
Clinical Data Registry of Amblyopia Patients on Luminopia Treatment
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
Common conditions studied in Philadelphia
- Breast Cancer (36 active studies)
- Cancer (25 active studies)
- Ovarian Cancer (22 active studies)
- Heart Failure (21 active studies)
- Prostate Cancer (21 active studies)
- Advanced Solid Tumor (18 active studies)
Leading research sponsors in Philadelphia
- University of Pennsylvania
- Abramson Cancer Center at Penn Medicine
- Children's Hospital of Philadelphia
- Thomas Jefferson University
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Philadelphia?
There are approximately 1,987 recruiting clinical trials in Philadelphia, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Philadelphia pay participants?
Most recruiting trials in Philadelphia compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Philadelphia?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Philadelphia?
The most common conditions under active study in Philadelphia include Breast Cancer (36), Cancer (25), Ovarian Cancer (22), Heart Failure (21), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Philadelphia?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Philadelphia on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Philadelphia?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Philadelphia?
Recruiting research sites in Philadelphia include University of Pennsylvania, Children's Hospital of Philadelphia, Thomas Jefferson University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Philadelphia right now?
The largest active categories in Philadelphia are Cancer & tumors (557), Neurology & pain (111), Cardiovascular (110). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Children's Hospital of Philadelphia?
Children's Hospital of Philadelphia is located at 3550 MARKET ST, 5TH FLOOR, PHILADELPHIA, PA 19104-3329. Use the Google Maps link in the intro above to get directions.
How do I contact Children's Hospital of Philadelphia?
You can reach Children's Hospital of Philadelphia by phone at (215) 590-4862. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.