Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in Pittsburgh +48 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
Women's health Clinical Trials in Pittsburgh, PA
As of September 2026, 69 paid clinical trials are recruiting for Women's health in Pittsburgh, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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69 clinical trials for Women's health
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Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
for Cervical Cancer
Sites in Pittsburgh, Monroeville +127 more locations
Sponsor: Pfizer
Sex: Female·Age: 18+
Code: NCT06952660·Phase 4·Recruiting·Listed May 2025
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
for Ovarian Cancer
Drug: INCB123667
Sites in Pittsburgh, York +55 more locations
Sponsor: Incyte Corporation
Sex: Female·Age: 18+
Code: NCT07214779·Phase 3·Recruiting·Listed Oct 2025
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
for Ovarian Cancer
Sites in Pittsburgh, Philadelphia +26 more locations
Sponsor: AbbVie
Sex: Female·Age: 18+
Code: NCT07059845·Phase 2·Recruiting·Listed Jul 2025
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
for Endometrial Cancer
Sites in Pittsburgh, Bethlehem +46 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: Female·Age: 18+
Code: NCT06952504·Phase 3·Recruiting·Listed May 2025
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
for Breast Cancer
Sites in Pittsburgh +60 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT06790693·Phase 3·Recruiting·Listed Jan 2025
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
for Breast Neoplasms
Sites in Pittsburgh, York +32 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT07060807·Phase 3·Recruiting·Listed Jul 2025
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
for Ovarian Cancer
Sites in Pittsburgh +34 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: Female·Age: 18+
Code: NCT06824467·Phase 3·Recruiting·Listed Feb 2025
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
for Breast Neoplasms
Sites in Pittsburgh, Allentown +36 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT06926868·Phase 2, Phase 3·Recruiting·Listed Apr 2025
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
for High Grade Epithelial Ovarian Cancer
Sites in Pittsburgh, Doylestown +35 more locations
Sponsor: Genmab
Sex: All·Age: 18+
Code: NCT05579366·Phase 1, Phase 2·Recruiting·Listed Oct 2022
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
for Advanced Solid Tumor
Sites in Pittsburgh, York +29 more locations
Sponsor: PMV Pharmaceuticals, Inc
Sex: All·Age: 12+
Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
for Platinum-resistant Ovarian Cancer
Drug: Bevacizumab
Sites in Pittsburgh +32 more locations
Sponsor: Genelux Corporation
Sex: Female·Age: 18+
Code: NCT05281471·Phase 3·Recruiting·Listed Mar 2022
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
for Breast Cancer
Sites in Pittsburgh, Bethlehem +111 more locations
Sponsor: Agendia
Sex: All·Age: 18+
Code: NCT03053193·Recruiting·Listed Feb 2017
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
for Breast Cancer
Sites in Pittsburgh, Harrisburg +51 more locations
Sponsor: Exact Sciences Corporation
Sex: All·Age: 18+
Code: NCT06401421·Recruiting·Listed May 2024
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
for Breast Cancer
Drug: Giredestrant
Sites in Pittsburgh, Hershey +26 more locations
Sponsor: Genentech, Inc.
Sex: All·Age: 18+
Code: NCT07100106·Phase 1, Phase 2·Recruiting·Listed Aug 2025
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
for Breast Neoplasms
Sites in Pittsburgh +14 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07114601·Phase 1·Recruiting·Listed Aug 2025
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
for Ovarian Cancer
Sites in Pittsburgh +16 more locations
Sponsor: Xencor, Inc.
Sex: All·Age: 15+
Code: NCT06276491·Phase 1·Recruiting·Listed Feb 2024
Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer
for Ovarian Cancer
Sites in Pittsburgh +20 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: Female·Age: 18+
Code: NCT06787612·Phase 2·Recruiting·Listed Jan 2025
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
for Ovarian Cancer
Sites in Pittsburgh, Philadelphia +11 more locations
Sponsor: NextCure, Inc.
Sex: All·Age: 18+
Code: NCT06774963·Phase 1·Recruiting·Listed Jan 2025
Lead-212 PSV359 Therapy for Patients With Solid Tumors
for Pancreatic Ductal Adenocarcinoma
Sites in Pittsburgh +10 more locations
Sponsor: Perspective Therapeutics
Sex: All·Age: 18 - 90
Code: NCT06710756·Phase 1, Phase 2·Recruiting·Listed Nov 2024
Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer
for Endometrial Cancer
Sites in Pittsburgh, Doylestown +16 more locations
Sponsor: Faeth Therapeutics
Sex: Female·Age: 18+
Code: NCT06463028·Phase 2·Recruiting·Listed Jun 2024
A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer
for Ovarian Cancer
Sites in Pittsburgh +12 more locations
Sponsor: Compugen Ltd
Sex: Female·Age: 18+
Code: NCT06888921·Phase 1, Phase 2·Recruiting·Listed Mar 2025
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.
for Endometrial Cancer
Drug: Lifileucel
Sites in Pittsburgh +11 more locations
Sponsor: Iovance Biotherapeutics, Inc.
Sex: Female·Age: 18 - 70
Code: NCT06481592·Phase 2·Recruiting·Listed Jul 2024
Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers
for Ovarian Cancer
Drug: Relacorilant
Sites in Pittsburgh +15 more locations
Sponsor: Corcept Therapeutics
Sex: Female·Age: 18+
Code: NCT06906341·Phase 2·Recruiting·Listed Apr 2025
A Phase 1 Study of the Safety and Tolerability of CTX-10726
for Gastroesophageal Cancer (GC)
Drug: CTX-10726
Sites in Pittsburgh +4 more locations
Sponsor: Compass Therapeutics
Sex: All·Age: 18+
Code: NCT07419841·Phase 1·Recruiting·Listed Feb 2026
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
for Ovarian Cancer
Sites in Pittsburgh +19 more locations
Sponsor: Tubulis GmbH
Sex: All·Age: 18+
Code: NCT06303505·Phase 1, Phase 2·Recruiting·Listed Mar 2024
Identifying Patterns in the Breath of Individuals With Breast Cancer
for Breast Cancer
Sites in Pittsburgh +3 more locations
Sponsor: Breathe BioMedical Inc
Sex: Female·Age: 40 - 74·Accepts healthy volunteers
Code: NCT06512350·Recruiting·Listed Jul 2024
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
for Cervical Cancer
Sites in Pittsburgh +6 more locations
Sponsor: Orano Med Theranostics, SAS
Sex: All·Age: 18+
Code: NCT05283330·Phase 1·Recruiting·Listed Mar 2022
A Study of Lorigerlimab in Participants With Advanced Solid Tumors
for Platinum-resistant Ovarian Cancer
Sites in Pittsburgh +6 more locations
Sponsor: MacroGenics
Sex: Female·Age: 18+
Code: NCT06730347·Phase 2·Recruiting·Listed Dec 2024
A Study of VET3-TGI in Patients With Solid Tumors
for Solid Tumor, Adult
Sites in Pittsburgh +6 more locations
Sponsor: KaliVir Immunotherapeutics
Sex: All·Age: 18+
Code: NCT06444815·Phase 1·Recruiting·Listed Jun 2024
A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers
for Epithelial Ovarian Cancer
Sites in Pittsburgh +4 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: Female·Age: 18+
Code: NCT06469281·Phase 1·Recruiting·Listed Jun 2024
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Pittsburgh, Monroeville +1087 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
"Vasectomy: Right for Me?" Decision Support Tool
for Vasectomy
Sites in Pittsburgh +1 more location
Sponsor: University of Pittsburgh
Sex: Male·Age: 21 - 55
Code: NCT07451067·Recruiting·Listed Mar 2026
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
for Ovarian Carcinoma
Sites in Pittsburgh, Monroeville +479 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 35 - 50
Code: NCT04251052·Recruiting·Listed Jan 2020
E-Mindfulness Approaches for Living After Breast Cancer
for Breast Cancer
Sites in Pittsburgh, Greensburg +372 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18 - 50
Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024
A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer
for Cervical Cancer
Sites in Pittsburgh, Wynnewood +115 more locations
Sponsor: GOG Foundation
Sex: Female·Age: 18+
Code: NCT04831580·Recruiting·Listed Apr 2021
ATEMPT 2.0: Adjuvant T-DM1 vs TH
for Breast Cancer
Sites in Pittsburgh, Philadelphia +44 more locations
Sponsor: Dana-Farber Cancer Institute
Sex: All·Age: 18+
Code: NCT04893109·Phase 2·Recruiting·Listed May 2021
Distance-Based Exercise to Preserve Function and Prevent Disability
for Localized Malignant Solid Neoplasm
Sites in Pittsburgh, Butler +16 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT07059884·Recruiting·Listed Jul 2025
Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer
for Anatomic Stage IV Breast Cancer AJCC v8
Drug: Tremelimumab
Sites in Pittsburgh +22 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT03606967·Phase 2·Recruiting·Listed Jul 2018
Treatment With Aspirin After Preeclampsia: TAP Trial
for Hypertensive Disorder of Pregnancy
1 location in Pittsburgh
Sponsor: Malamo Countouris
Sex: Female·Age: 18 - 55
Code: NCT06281665·Phase 4·Recruiting·Listed Feb 2024
Top Research Study Locations in Pittsburgh
Researchers run research studies in Pittsburgh, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pittsburgh | Stroke, Traumatic Brain Injury, Dementia | 155 |
| UPMC Hillman Cancer Center | Melanoma, Metastatic Malignant Solid Neoplasm, Acute Myeloid Leukemia | 147 |
| University of Pittsburgh Medical Center | Chronic Pancreatitis, Cystic Fibrosis, Advanced Solid Tumor | 132 |
| Allegheny General Hospital | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Heart Failure | 64 |
| Children's Hospital of Pittsburgh of UPMC | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Neuroblastoma | 58 |
| UPMC Children's Hospital of Pittsburgh | Fabry Disease, Cerebral Palsy, Congenital Bone Marrow Failure Syndromes | 53 |
| Allegheny Health Network | Brain Tumor, Breast Cancer, Colorectal Cancer | 33 |
| UPMC-Passavant Hospital | Anatomic Stage II Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Stage IV Renal Cell Cancer AJCC v8 | 31 |
| UPMC-Saint Clair Hospital Cancer Center | Anatomic Stage II Breast Cancer AJCC v8, Head and Neck Squamous Cell Carcinoma, Stage III Laryngeal Cancer AJCC v8 | 26 |
| UPMC-Saint Margaret | Stage III Laryngeal Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8, Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | 24 |
| West Penn Hospital | Large B-cell Lymphoma, Stage IV Colorectal Cancer AJCC v8, Acute Lymphoblastic Leukemia (ALL) | 23 |
| UPMC Presbyterian | Acute Kidney Injuries, Aneurysm of Aorta, Thoracic, Aneurysmal Disease | 20 |
| UPMC-Magee Womens Hospital | Anatomic Stage II Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Anatomic Stage I Breast Cancer AJCC v8 | 20 |
| UPMC Presbyterian Hospital | Abdominal Surgery, Acute Ischemic Stroke, Acute Myocardial Infarction | 19 |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA | Cardiovascular Diseases, Stroke, Acute Kidney Injury | 19 |
| UPMC | Focal Epilepsy, ASD - Atrial Septal Defect, Advanced Melanoma | 18 |
| UPMC-Shadyside Hospital | Head and Neck Squamous Cell Carcinoma, Stage II Lip and Oral Cavity Cancer AJCC v8, Stage III Laryngeal Cancer AJCC v8 | 18 |
| University of Pittsburgh Cancer Institute (UPCI) | Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma | 16 |
| Children's Hospital of Pittsburgh | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Adolescent Congenital Heart Disease | 13 |
| University of Pittsburgh Medical Center (UPMC) | ALS, ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis | 9 |
| AHN Allegheny General Hospital | Breast Cancer, Cancer, Carcinoma, Non-Small-Cell Lung | 8 |
| AHN West Penn Hospital | Malignant Mesothelioma, Malignant Pleural Effusion, Metastasis to Pleura | 8 |
| UPMC Magee-Womens Hospital | ADHD, Behavioral Intervention, Cervical Cancer | 8 |
| University of Pittsburgh School of Medicine | Adolescents, Anorexia Nervosa, Bipolar Disorder (BD) | 8 |
| UPMC Shadyside Hospital | Abdominal Surgery, Dementia, Harm Reduction | 7 |
Active & Upcoming Studies in Pittsburgh (2026)
Recruiting trials in Pittsburgh grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (396 active studies)
- Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · University of Pittsburgh
- A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information · Children's Oncology Group
Neurology & pain (81 active studies)
- Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · University of Pittsburgh
- Psilocybin After Trauma Surgery for Pain · Phase 1 · Trent Emerick
Cardiovascular (74 active studies)
- TEPH: Telaglenastat Efficacy in Pulmonary Hypertension · Phase 1, Phase 2 · Chan, Stephen, MD, PhD
- Precision Analgesia for Cardiac Surgery · Kathirvel Subramaniam
Diabetes & metabolic (39 active studies)
- Technology Knowledge Optimization for Type 1 Diabetes in Schools · University of Pittsburgh
- Network-Based Support to Help Community Coalition Members Choose and Use Strategies to Improve Child Health · University of Pittsburgh
Mental health & behavior (37 active studies)
Pediatric (19 active studies)
- Hypoxic Red Blood Cells in Sickle Cell Anemia · Hemanext
- A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients · Phase 2 · Costas Hadjipanayis
HIV / STI (8 active studies)
- Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver) · Johns Hopkins University
- Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Vaccines (7 active studies)
Eye & vision (3 active studies)
- A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · Astellas Pharma Global Development, Inc.
- The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease · Rinsada
Common conditions studied in Pittsburgh
- Breast Cancer (24 active studies)
- Cancer (19 active studies)
- Ovarian Cancer (17 active studies)
- Endometrial Cancer (16 active studies)
- Stroke (16 active studies)
- Melanoma (15 active studies)
Leading research sponsors in Pittsburgh
- University of Pittsburgh
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
- VA Office of Research and Development
Frequently asked questions
How many paid clinical trials are currently recruiting in Pittsburgh?
There are approximately 1,240 recruiting clinical trials in Pittsburgh, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Pittsburgh pay participants?
Most recruiting trials in Pittsburgh compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Pittsburgh?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Pittsburgh?
The most common conditions under active study in Pittsburgh include Breast Cancer (24), Cancer (19), Ovarian Cancer (17), Endometrial Cancer (16), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Pittsburgh?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Pittsburgh on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Pittsburgh?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Pittsburgh?
Recruiting research sites in Pittsburgh include University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Pittsburgh right now?
The largest active categories in Pittsburgh are Cancer & tumors (396), Neurology & pain (81), Cardiovascular (74). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
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