Migraine Clinical Trials in Smithfield, PA

As of June 2026, 2 paid clinical trials are recruiting for Migraine in Smithfield, Pennsylvania. Migraine trials evaluate CGRP antagonists, gepants, and new acute and preventive therapies for chronic and episodic migraine. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .

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2 clinical trials for Migraine

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About research studies in Smithfield

Smithfield has approximately 12 recruiting research studies across a wide range of therapeutic areas. Pennsylvania hosts UPenn's Perelman School of Medicine and Children's Hospital of Philadelphia — pioneers in CAR-T cell therapy — alongside UPMC, Thomas Jefferson University, and Penn State Hershey.

Top Research Study Locations in Smithfield

Researchers run research studies in Smithfield, PA at 3 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.

SiteSpecializes inActive trials
Frontier Clinical Research, LLCIrritable Bowel Syndrome With Constipation (IBS-C), Lyme Disease3
Frontier Clinical Research - SmithfieldMigraine, Chronic Migraine3
Frontier Clinical ResearchCardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension2

Active & Upcoming Studies in Smithfield (2026)

Recruiting trials in Smithfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.

Common conditions studied in Smithfield

  • Irritable Bowel Syndrome With Constipation (IBS-C) (2 active studies). Recruiting Irritable Bowel Syndrome With Constipation (IBS-C) studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Migraine (2 active studies). Migraine trials evaluate CGRP antagonists, gepants, and new acute and preventive therapies for chronic and episodic migraine.
  • Asthma (1 active study). Asthma research tests biologic therapies targeting IL-4, IL-5, and TSLP pathways for moderate-to-severe and eosinophilic disease.
  • Cardiovascular Disease (1 active study). Recruiting Cardiovascular Disease studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Cardiovascular Diseases (1 active study). Recruiting Cardiovascular Diseases studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Chronic Migraine (1 active study). Migraine trials evaluate CGRP antagonists, gepants, and new acute and preventive therapies for chronic and episodic migraine.

Leading research sponsors in Smithfield

  • AstraZeneca
  • AbbVie
  • Ardelyx
  • Boehringer Ingelheim
  • Hoffmann-La Roche

Local regulations and guidelines

Clinical trials in Pennsylvania are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Pennsylvania research additionally follows state public health department oversight and any applicable state privacy statutes.

Compensation & what to expect

How payment typically works
Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
Healthy volunteers
Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Smithfield. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
What's included beyond payment
Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
Travel and time
Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
Asking about compensation
Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.

How to find a clinical trial in Smithfield

Hipa.ai aggregates every recruiting study in Smithfield from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.

Frequently asked questions

How many paid clinical trials are currently recruiting in Smithfield?

There are approximately 12 recruiting clinical trials in Smithfield, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Smithfield pay participants?

Most recruiting trials in Smithfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Smithfield?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Smithfield?

The most common conditions under active study in Smithfield include Irritable Bowel Syndrome With Constipation (IBS-C) (2), Migraine (2), Asthma (1), Cardiovascular Disease (1), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Smithfield?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Smithfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Smithfield?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Where can I take part in paid clinical trials in Smithfield?

Recruiting research sites in Smithfield include Frontier Clinical Research, LLC, Frontier Clinical Research - Smithfield, Frontier Clinical Research, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.

What kinds of studies are recruiting in Smithfield right now?

The largest active categories in Smithfield are Neurology & pain (3), Vaccines (2), Cardiovascular (2). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.

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Trials by condition in Smithfield