Oncology Clinical Trials in Worcester, MA
As of August 2026, 30 paid clinical trials are recruiting for Oncology in Worcester, Massachusetts. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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30 clinical trials for Oncology
·Clear filters·Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
Project: Every Child for Younger Patients With Cancer
Pancreatic Cancer Early Detection Consortium
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick
A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
Top Research Study Locations in Worcester
Researchers run research studies in Worcester, MA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Massachusetts Chan Medical School | Immune Thrombocytopenic Purpura (ITP), Acute Stress Reaction, Autoimmune Diseases | 29 |
| UMass Memorial Medical Center - University Campus | Stage IV Lung Cancer AJCC v8, B Acute Lymphoblastic Leukemia, Lung Non-Small Cell Carcinoma | 26 |
| UMass Memorial Medical Center | Intracerebral Hemorrhage, Acute Kidney Injury, Atrial Fibrillation | 19 |
| UMass Chan Medical School | Atrial Fibrillation, AML With Mutated NPM1, ASCVD | 17 |
| University of Massachusetts Memorial Medical Center | Pregnancy, High Risk, B-cell Malignancy, Becker Muscular Dystrophy | 13 |
| University of Massachusetts | Abdominal Aortic Aneurysm, Acute Ischemic Stroke, Acute Myeloid Leukemia (AML) | 11 |
| University of Massachusetts Medical School | Neoplasm Metastasis, Alcohol; Use, Problem, Amyotrophic Lateral Sclerosis | 9 |
| UMass Memorial Health | Clostridium Difficile Infection, Depression / Major Depressive Disorder, Fecal Microbiota Transplantation | 4 |
| Vitalix Clinical | Major Depressive Disorder, Alzheimer's Disease, Post Traumatic Stress Disorder | 4 |
| University of Massachusetts Medical Center | Aortic Valve Disease, Aortic Valve Stenosis, COACH | 3 |
| GSK Investigational Site | Multiple Myeloma, Neoplasms, Head and Neck, Newly Diagnosed Multiple Myeloma | 2 |
| Local Institution - 0059 | Schizophrenia, Autism-Related Irritability | 2 |
| Reliant Medical Group | Asthma, Asthma Attack, Asthma Exacerbations | 2 |
| UMass/Shields | Esophageal Cancer, Gastric Cancer (GC), Gastroesophageal Junction | 2 |
| UMassMemorial Health Care | Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder, Wellness, Psychological | 2 |
| University of Massachusetts Memorial Health | Lupus Nephritis, Neuropsychiatric Systemic Lupus Erythematosus, Postpartum Hypertension | 2 |
| University of Massachusetts Memorial Health Care | Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation | 2 |
| UMass Memorial Medical Center - Belmont Street | Advanced High-Grade Epithelial Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Cancer | 2 |
| Central Massachusetts Health Center | Alcohol-Related Disorders, Contraception, Maternal Health | 1 |
| Clinical Research | Immunoglobulin A Nephropathy | 1 |
| Clinical Study Site | Non-Small Cell Lung Cancer | 1 |
| Community Care Cooperative (C3) | Depression / Major Depressive Disorder, Food Insecurity | 1 |
| Decentralized | Adherence, Medication, Anticoagulants and Bleeding Disorders, Atrial Fibrillation | 1 |
| Family Health Center of Worcester | Depression, Diabetes, Hyperlipidemias | 1 |
| Investigator | Focal Segmental Glomerulosclerosis | 1 |
Active & Upcoming Studies in Worcester (2026)
Recruiting trials in Worcester grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (53 active studies)
- Facilitation of Information eXchange for Shared Decision Making for Lung Cancer Screening · University of Massachusetts, Worcester
- Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2 · Phase 3 · AstraZeneca
Mental health & behavior (14 active studies)
- The Medically Tailored Groceries and Mental Health Study · University of Massachusetts, Worcester
- ALTO-207 in Adults With Treatment-resistant Depression (TRD) · Phase 2 · Alto Neuroscience
Neurology & pain (14 active studies)
- Social Media and Risk-reduction Training for Preterm Infant Care Practices · University of Massachusetts, Worcester
- Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts · University of Massachusetts, Worcester
Cardiovascular (11 active studies)
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF · Phase 3 · AstraZeneca
- Social Needs Screening and Chronic Diseases Study (WE CARE) · University of Massachusetts, Worcester
Diabetes & metabolic (7 active studies)
- Food is Medicine in Pediatric Patients With Diabetes · University of Massachusetts, Worcester
- A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin · Phase 3 · AstraZeneca
Vaccines (5 active studies)
- Patient-Centered Practical Vaccine Talk For Busy Clinicians · University of Massachusetts, Worcester
- A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine · Phase 3 · Pfizer
Pediatric (4 active studies)
- Social Media and Risk-reduction Training for Preterm Infant Care Practices · University of Massachusetts, Worcester
- Social Needs Screening and Chronic Diseases Study (WE CARE) · University of Massachusetts, Worcester
Eye & vision (3 active studies)
- CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma · EARLY_Phase 1 · MCPHS University
HIV / STI (1 active study)
Common conditions studied in Worcester
- Schizophrenia (5 active studies)
- Major Depressive Disorder (4 active studies)
- Stage IV Lung Cancer AJCC v8 (4 active studies)
- Acute Myeloid Leukemia (3 active studies)
- Atrial Fibrillation (3 active studies)
- B Acute Lymphoblastic Leukemia (3 active studies)
Leading research sponsors in Worcester
- University of Massachusetts, Worcester
- National Cancer Institute (NCI)
- Children's Oncology Group
- AstraZeneca
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Worcester?
There are approximately 208 recruiting clinical trials in Worcester, Massachusetts listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Worcester pay participants?
Most recruiting trials in Worcester compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Worcester?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Worcester?
The most common conditions under active study in Worcester include Schizophrenia (5), Major Depressive Disorder (4), Stage IV Lung Cancer AJCC v8 (4), Acute Myeloid Leukemia (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Worcester?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Worcester on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Worcester?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Worcester?
Recruiting research sites in Worcester include University of Massachusetts Chan Medical School, UMass Memorial Medical Center - University Campus, UMass Memorial Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Worcester right now?
The largest active categories in Worcester are Cancer & tumors (53), Mental health & behavior (14), Neurology & pain (14). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.