Glioma Clinical Trials

Recruiting glioma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat glioma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting glioma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting glioma trials

Within

Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease

for Grade 2 IDH1-mutant Glioma

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT07703436·Phase 2

Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG

for High Grade Glioma

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 - 39

Code: NCT07644312·Phase 2

A Study for Cerebral Open Flow Microperfusion

for Glioma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07089758

Clinical Benefit of 18F-FET in Glioma.

for Glioma

Sponsor: Primo Biotechnology Co., Ltd

Sex: All·Age: 20+·Accepts healthy volunteers

Code: NCT07698457·Phase 3

Monitoring of Neurological Symptoms, Treatment Tolerance, and Quality of Life Using the Resilience PRO Electronic Patient-reported Outcome Application in Patients With IDH-mutated Glioma

for Oncology

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07439302

Movie-Watching Functional MRI for Mapping Brain Function in Neurosurgical Patients

for Glioma

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 70

Code: NCT07650994

Language Network Prehab Via fMRI Neurofeedback

for Glioma

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07488780

A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas

for Glioma

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18 - 65

Code: NCT04745156

EEG-Guided Cognitive Function Preservation in Patients With Brain Tumors

for Glioma

Sponsor: Bo Wang

Sex: All·Age: 18 - 75

Code: NCT07699172

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

for Glioma

1 site in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 - 21

Code: NCT05555550·EARLY_Phase 1

Apply to this trial

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for Recurrent Glioblastoma

1 site in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 99

Code: NCT07416188·Phase 1, Phase 2

Apply to this trial

AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors

for Pediatric Brain Tumors

Sponsor: Huashan Hospital

Sex: All·Age: 0 - 17

Code: NCT07703605

A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma

for HGG

Sponsor: Neuregen Therapeutics Co., Ltd.

Sex: All·Age: 18+

Code: NCT07710690·Phase 1

Apply to this trial

Evaluation of [⁶⁸Ga/¹⁷⁷Lu]HT547: Safety, Biodistribution, and Dosimetry in Solid Tumors

for Breast Cancer

Sponsor: Hua Pang

Sex: All·Age: 18 - 90

Code: NCT07639970·EARLY_Phase 1

A Study of HF1K16 Combined With Bevacizumab in Patients With Recurrent or Progressive Glioma

for Glioma

Sponsor: HighField Biopharmaceuticals Corporation

Sex: All·Age: 18 - 75

Code: NCT07678684·Phase 2

Apply to this trial

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for Glioma

1 site in Iowa City

Sponsor: Kailin Yang, MD, PhD

Sex: All·Age: 18+

Code: NCT07541781·Phase 1

Apply to this trial

Using the Epitranscriptome to Diagnose and Treat Gliomas

for Glioma

Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06575452

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Pharmacoscopy for Patients With Refractory Primary Brain Tumors

for Brain (Nervous System) Cancers

Sponsor: University of Zurich

Sex: All·Age: 18+

Code: NCT06804655·Phase 2

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

for High Grade Glioma (HGG) of the Brain With BRAF Aberration

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT07206849·Phase 2

A First-in-Human Study of the CIPHER System During Brain Surgery for Newly Diagnosed Glioma

for Glioma

Sponsor: Coherence Neuro Australia Pty Limited

Sex: All·Age: 18 - 75

Code: NCT07465796

Apply to this trial

Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors

for High Grade Glioma

Sponsor: Clinica Universidad de Navarra, Universidad de Navarra

Sex: All·Age: 1 - 25

Code: NCT07424092·Phase 2

Apply to this trial

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for Glioblastoma (GBM)

21 sites incl. Springdale

Sponsor: Black Diamond Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07326566·Phase 2

Apply to this trial

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

for High Grade Glioma

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 3

Code: NCT06528691·Phase 2

Apply to this trial

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

Apply to this trial

Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation

for Glioma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 36 Months+

Code: NCT07076498·Phase 1

Apply to this trial

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

for Glioblastoma Multiforme of Brain

3 sites incl. Tampa

Sponsor: Tetragon Biosciences Ltd

Sex: All·Age: 18+

Code: NCT07464925·Phase 1

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A Study of Mirdametinib in People With Central Nervous System Tumors

for Central Nervous System Tumors

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07539441·Phase 1, Phase 2

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Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma

for Glioma

Sponsor: Huashan Hospital

Sex: All·Age: 18+

Code: NCT07469735

Neuromodulation-Induced Cortical Prehabilitation in High Grade Glioma Near the Motor Pathway: Cortical Plasticity Assessed by Navigated Transcranial Magnetic Stimulation (nTMS)

for Brain Tumor Adult

Sponsor: Azienda Sanitaria dell'Alto Adige

Sex: All·Age: 18 - 80

Code: NCT07471100

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

for Brain Cancer

1 site in Nashville

Sponsor: Eben Rosenthal

Sex: All·Age: 18+

Code: NCT07210632·EARLY_Phase 1

Apply to this trial

Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG

for Malignant Brain Tumors

2 sites incl. Cleveland

Sponsor: Tiffany Hodges

Sex: All·Age: 18+

Code: NCT07438860·Phase 1

DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

for Haematological Malignancy

Sponsor: Cancer Research UK

Sex: All·Age: 1+

Code: NCT07440290·Phase 2, Phase 3

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

for AML (Acute Myeloid Leukemia)

2 sites incl. Orange

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07486713·Phase 4

Apply to this trial

Self-administered Remote Neurological Examination Using Mobile Application in Patients With Brain Tumors

for CNS Tumor

Sponsor: Tata Memorial Centre

Sex: All·Age: 5+

Code: NCT07236840

Apply to this trial

Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors

for Brain Tumor Adult

Sponsor: Medical University of Warsaw

Sex: All·Age: 18+

Code: NCT07411690

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Leica Microsystems Sponsored PMCF Study to Collect and Confirm Clinical Data on the Performance of the GLOW400 Device When Used in Accordance With Its Intended Use

for Suspected Grade III and IV Gliomas Requiring Surgical Intervention

Sponsor: Leica Microsystems (Schweiz) AG

Sex: All·Age: 18+

Code: NCT07366892

Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures

for Brain Tumor Adult

Sponsor: Medical University of Warsaw

Sex: All·Age: 18+

Code: NCT07413796

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A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

for Pediatric Tumor of CNS

Sponsor: Neonc Technologies, Inc.

Sex: All·Age: 5 - 18

Code: NCT06357377·Phase 1

A Study to Evaluate the Safety and Efficacy of L19TNF With Alkylating Chemotherapy for Patients With Recurrent IDH-mutant Astrocytoma or Oligodendroglioma

for Glioma

Sponsor: Philogen S.p.A.

Sex: All·Age: 18+

Code: NCT07120984·Phase 2

AI-driven Processing and Analysis of Glioma Imaging Data

for Glioma

Sponsor: Università degli Studi di Trento

Sex: All·Age: 18 - 60

Code: NCT07703761

Apply to this trial

Symptom Cluster Heterogeneity and Gut Microbiota Mechanisms in Childhood Cancer Survivors

for Cancer

Sponsor: The Children's Hospital of Zhejiang University School of Medicine

Sex: All·Age: 8 - 18

Code: NCT07450872

Apply to this trial

Residual IDH1-Mutant Tumor Cell Quantification Study

for Glioma

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07219199

Vorasidenib in CNS WHO Grade 2 IDH-mutant Diffuse Glioma

for Glioma

Sponsor: iOMEDICO AG

Sex: All·Age: 18+

Code: NCT07240662

Apply to this trial

Prognostic IntraOperative Biomarkers ideNtification in Tumor rElatEd suRgery

for Glioma

Sponsor: Erasmus Medical Center

Sex: All·Age: 18 - 90

Code: NCT06617208

Construction and Application of an IDH Mutation-Targeted PET/MRI Imaging Framework for Precision Diagnosis of Gliomas

for Glioma

Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Sex: All·Age: 18+

Code: NCT07405372

Apply to this trial

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

for Haematological Malignancy

Sponsor: Cancer Research UK

Sex: All·Age: All ages

Code: NCT05770544·Phase 2, Phase 3

Apply to this trial

BIO-SHORT: Hypofractionated RT for Poor-Prognosis GBM

for Glioma

Sponsor: Tata Memorial Centre

Sex: All·Age: 50+

Code: NCT07338539

Apply to this trial

Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors

for Glioma

Sponsor: Centre Leon Berard

Sex: All·Age: 12+

Code: NCT07243470·Phase 1, Phase 2

Apply to this trial

A Study of 177Lu-PSMA-617 in People With Gliomas

for Glioma

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07223034·Phase 1

Apply to this trial

Glioma Intraoperative MicroElectroCorticoGraphy

for Glioma

Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Sex: All·Age: 18+

Code: NCT06408428

Protoporphyrin Imaging in Multispectral Evaluation of Resections

for Glioma

Sponsor: Medical University Innsbruck

Sex: All·Age: 18 - 99

Code: NCT07021573

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

for Glioma

2 sites incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07074756

Apply to this trial

Prospective Real-World Study of Pathology AI for Glioma Molecular Prediction

for Glioma

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 100

Code: NCT07263711

Apply to this trial

Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients

for Glioma

Sponsor: Tanta University

Sex: All·Age: 18 - 75

Code: NCT06750458·Phase 3

Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease

for Glioma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07025226·EARLY_Phase 1

Apply to this trial

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

10 sites incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1

Apply to this trial

Clinical Study for the Safety and Therapeutic Efficacy of the AI-QMMM Designed TamavaqTM Personalised Vaccine in Patients With Newly Diagnosed Glioma.

for Glioma

Sponsor: Biogenea Pharmaceuticals Ltd.

Sex: All·Age: 18+

Code: NCT07077616·EARLY_Phase 1

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Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

for GBM

Sponsor: Sunnybrook Health Sciences Centre

Sex: All·Age: 18 - 85

Code: NCT07179328·Phase 1

Apply to this trial

ASCENT Intervention for Brain Tumor Patients

for Malignant Brain Tumor

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06099743

Apply to this trial

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

for Glioma

2 sites incl. Boca Raton

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT06397560

Apply to this trial

Glioma clinical trials — common questions

Are glioma clinical trials free to join?

Yes. Participating in a glioma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a glioma clinical trial?

Each glioma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a glioma trial near me?

Use the location controls above. We'll show recruiting glioma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many glioma trials are recruiting right now?

We're currently tracking roughly 88 recruiting glioma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Glioma trials by city

Aurora, CO Birmingham, AL Cleveland, OH Boston, MA Miami, FL San Francisco, CA Los Angeles, CA Orange, CA Boca Raton, FL Cincinnati, OH Columbus, OH Detroit, MI

Related specialties

Oncology Neuro-oncology