Opioid use disorder Clinical Trials

Recruiting opioid use disorder studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat opioid use disorder. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting opioid use disorder studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting opioid use disorder trials

Within

Dynamic Treatment Regimes for Opioid Use Disorder

for Opioid Use Disorder

1 site in Irvine

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07011758·Phase 2

Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans

for Opioid Use Disorder

1 site in Northport

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06766331

Family-Focused Study to Support Medication for Opioid Use Disorder

for Opioid Use Disorder

2 sites incl. Chicago

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07451197

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

for Alcohol Use Disorder

1 site in Portland

Sponsor: Washington State University

Sex: All·Age: 18+

Code: NCT07171359

Apply to this trial

Evaluating a Digital Toolkit for IPV

for Opioid Use Disorder

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07600307

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

for Opioid Use Disorder

4 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07361432·Phase 3

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

for Opioid Use Disorder

1 site in Detroit

Sponsor: Wayne State University

Sex: All·Age: 21 - 60

Code: NCT04231708·Phase 2

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

Apply to this trial

Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

for Opioid Use Disorder

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT07148206·Phase 3

Improving Hospital-To-Methadone Clinic Connection Using Implementation Support for Patients With Opioid Use Disorder

for Opioid Use Disorder

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07568847

Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)

for Opioid Use Disorder

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07607743

Methadone Expansion in Detention Though the Hospital/Clinic Designation

for Opioid Use Disorder

Sponsor: Brendan Saloner

Sex: All·Age: 18+

Code: NCT07707934

Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention

for Opioid Use Disorder

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06341608

A Bundled Intervention to End Opioid Overdoses

for Opioid Use Disorder

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 19+

Code: NCT07485335·Phase 4

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

for Opioid Use Disorder

4 sites incl. Miami

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07216963

Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs

for HEPATITIS C (HCV)

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07631559

Evaluation of Clinical Decision Support in Opioid Tapering

for Medication Abuse

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 89·Accepts healthy volunteers

Code: NCT06527079

Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study

for Cannabis Use Disorder

1 site in San Bernardino

Sponsor: Loma Linda University

Sex: All·Age: 18+

Code: NCT07001371

Examining Analgesic Synergy and Efficacy in Trauma Care

for Opioid Use Disorder

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT07435077·Phase 4

Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses

for Opioid Use Disorder

8 sites incl. Los Angeles

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07631598

Safety, Tolerability, and Pharmacokinetics of MCAM in Healthy Adult Participants

for Opioid Use Disorder

1 site in Overland Park

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07602335·EARLY_Phase 1

Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)

for HIV Pre-exposure Prophylaxis

1 site in Colbert

Sponsor: University of Georgia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06799702

Social Functioning in Opioid Use Disorder

for Opioid Use Disorder

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07044466

Apply to this trial

Ketones for Opioid Craving

for Opioid Use Disorder

1 site in Wernersville

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 75

Code: NCT07128524·Phase 2

Cannabis Effects on Opioid Self-Administration

for Opioid Use Disorder

1 site in Lexington

Sponsor: Shanna Babalonis, PhD

Sex: All·Age: 18 - 55

Code: NCT07668635·Phase 1

Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare Workers and Peer Supporters, and Implementation of Evidence Based Interventions.

for Substance Use Disorder

1 site in Columbus

Sponsor: Alicia Bunger

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07439783

Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons

for Opioid Use Disorder

Sponsor: Go Medical Industries Pty Ltd

Sex: All·Age: 18 - 65

Code: NCT05382091·Phase 2

Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD

for Opioid Use Disorder

1 site in San Antonio

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18+

Code: NCT07348796

Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery

for Opioid Use Disorder

1 site in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07693270

Apply to this trial

NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings

for HIV Infections

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06854029·Phase 4

Development of an Opioid Withdrawal Clinical Outcome Assessment

for Opioid Use Disorder

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07094672

SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery

for Postoperative Pain

Sponsor: Engin Çetin

Sex: Female·Age: 18 - 65

Code: NCT07674836

VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

for ACL

1 site in New York

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06456268

Apply to this trial

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

for Medication Abuse

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 89·Accepts healthy volunteers

Code: NCT06526286

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

for Substance Use Disorders

1 site in Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07232641

Apply to this trial

OpioidRedoxStudyII

for Oxidative Stress

Sponsor: EPC Education s.r.o.

Sex: All·Age: All ages

Code: NCT07338084

Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation

for Opioid Use Disorder

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07469501·Phase 4

EMS-Initiated Buprenorphine

for Opioid Use Disorder

3 sites incl. Oakland

Sponsor: Yale University

Sex: All·Age: All ages

Code: NCT07475728

Cerebral Physiology of NOWS

for Neonatal Opioid Withdrawal

Sponsor: Indiana University

Sex: All·Age: Up to 1 Day·Accepts healthy volunteers

Code: NCT07610746

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

for Overdose Risk

1 site in Harlan

Sponsor: Michele Staton

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07179614

Apply to this trial

Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention

for Alcohol Drinking

1 site in Providence

Sponsor: Brown University

Sex: All·Age: 18 - 25·Accepts healthy volunteers

Code: NCT07663448

Apply to this trial

Sublingual Buprenorphine Through Telemedicine vs In-Person Care as Usual

for Opioid Use Disorder

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18+

Code: NCT05339256·Phase 2

Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

for Opioid Use Disorder

3 sites incl. Bridgeport

Sponsor: Yale University

Sex: Female·Age: 18+

Code: NCT07115030

Apply to this trial

A Clinical Trial of Telehealth Treatment for Opioid Use Disorders

for Opioid Use Disorder

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07362082

Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment

for Opioid Use Disorder

2 sites incl. San Diego

Sponsor: Tools4Patient

Sex: All·Age: 18+

Code: NCT07456930

Methadone Rapid Restart

for Opioid Use Disorder

Sponsor: Pouya Azar

Sex: All·Age: 19+

Code: NCT07546396·Phase 4

Resilience Among Individuals With Opioid Use Disorder

for Opioid Use Disorder

2 sites in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06954402

Apply to this trial

Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2

for Opioid Use Disorder

3 sites incl. Guilford

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07602218

Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine

for Opioid Use Disorder

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07278518

Apply to this trial

Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy

for Mastectomy

Sponsor: American University of Beirut Medical Center

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07561411

Apply to this trial

Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use

for Opioid Use

1 site in Houston

Sponsor: Christopher D. Verrico

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07218549·Phase 1

Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery

for Orthopaedic Fractures

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT07486505

Serratus vs ESP Block for Postoperative Pain in Unilateral Breast Surgery

for Post Operative Pain

Sponsor: Engin Çetin

Sex: Female·Age: 18 - 65

Code: NCT07541040

Apply to this trial

Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic

for Opioid Use Disorder

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07176351·Phase 4

Pilot of Mailing Buprenorphine

for Opioid Use Disorder

2 sites in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07421102·EARLY_Phase 1

Apply to this trial

Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial

for Opioid Use Disorder

Sponsor: Pouya Azar

Sex: All·Age: 19+

Code: NCT07439549·Phase 4

Apply to this trial

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

for Opioid Use Disorder

1 site in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 18+

Code: NCT07541417

Apply to this trial

iSTEP-N 101b: Pharmacokinetics and Safety Study of Low- and High-Dose Naltrexone Implants vs Monthly Vivitrol in Healthy Volunteers

for Opioid Use Disorder

Sponsor: Akyso Therapeutics, LLC

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07064564·Phase 1

Autonomic Neural Blockade in Bariatric Surgery

for Bariatric Surgery Candidate

1 site in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 18 - 90

Code: NCT07104825

Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

for Alcohol Use Disorder

1 site in Notre Dame

Sponsor: University of Notre Dame

Sex: All·Age: 18+

Code: NCT07342504

Apply to this trial

Opioid use disorder clinical trials — common questions

Are opioid use disorder clinical trials free to join?

Yes. Participating in a opioid use disorder clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a opioid use disorder clinical trial?

Each opioid use disorder study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a opioid use disorder trial near me?

Use the location controls above. We'll show recruiting opioid use disorder trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many opioid use disorder trials are recruiting right now?

We're currently tracking roughly 229 recruiting opioid use disorder trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Opioid use disorder trials by city

Boston, MA Birmingham, AL Ann Arbor, MI Indianapolis, IN Chicago, IL Columbus, OH Detroit, MI La Jolla, CA Oakland, CA San Francisco, CA Portland, OR Seattle, WA

Related specialties

Behavioral health Addiction medicine