Peripheral artery disease Clinical Trials

Recruiting peripheral artery disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat peripheral artery disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting peripheral artery disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting peripheral artery disease trials

Within

Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion

for Ischemia Reperfusion Injury

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 21 - 70·Accepts healthy volunteers

Code: NCT06369350·EARLY_Phase 1

PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study

for Heart Failure

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT05377320

XPAD European Feasibility Study

for Peripheral Arterial Disease

Sponsor: Xeltis

Sex: All·Age: 18+

Code: NCT07716020

Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease

for Peripheral Arterial Disease

Sponsor: Biruni University

Sex: All·Age: 50 - 70

Code: NCT07550959

Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease

for Cardiorenal Metabolic Syndrome

Sponsor: Peking University Third Hospital

Sex: All·Age: 18+

Code: NCT07704190·Phase 4

Artificial Intelligence for Early Detection of Peripheral Artery Disease

for Peripheral Arterial Disease

Sponsor: University of California, San Diego

Sex: All·Age: 50 - 85·Accepts healthy volunteers

Code: NCT06505317

Shortwave Diathermy In-home Treatment for Indianapolis VA-only Patients Diagnosed With Peripheral Artery Disease and Peripheral Neuropathy

for Peripheral Arterial Disease

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07336381

In-Hospital Wearable-Based Monitoring Versus Standard Care in Cardiovascular Disease (INSPIRE)

for Cardiovascular Diseases

Sponsor: Yonsei University

Sex: All·Age: 20+

Code: NCT07622485

Study to Image Inflammatory Activity of a Fluorescence Imaging Agent in Excised Human Artery Plaques

for Carotid Artery Diseases

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06957821·EARLY_Phase 1

A Single Arm Trial to Evaluate the Safety and Efficacy of the Long (> 150mm) PasseoTM-18 LuxTM Drug-coated Balloon in the Treatment of Subjects With Infrainguinal Stenotic, Restenotic or Occlusive Lesions

for Drug Coated Balloon

Sponsor: KANDO Research

Sex: All·Age: 18 - 99

Code: NCT07385573

The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants

for Acute Coronary Syndromes (ACS)

1 site in Miami

Sponsor: Shanghai CureGene Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07619885·Phase 1

Apply to this trial

Evaluating Bu Yang Huanwu Decoction For Early Diabetic Vascular Disease

for Peripheral Arterial Disease

Sponsor: Xuanwu Hospital, Beijing

Sex: All·Age: 18 - 70

Code: NCT07658807·Phase 3

Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease

for Peripheral Artery Disease

Sponsor: Laval University

Sex: All·Age: 18+

Code: NCT07655206

Apply to this trial

Effectiveness of an Inpatient Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation

for Diabetes Mellitus

Sponsor: Instituto Nacional de Rehabilitacion

Sex: All·Age: 18+

Code: NCT07665775

Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study

for Peripheral Arterial Disease

Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Sex: All·Age: 18+

Code: NCT07672249

Apply to this trial

Cell Therapy for Lower Limb Ulcers in Patients With Critical Limb Ischemia

for Peripheral Arterial Disease

Sponsor: UPECLIN HC FM Botucatu Unesp

Sex: All·Age: 18 - 90

Code: NCT06326203·Phase 1, Phase 2

CT Body Composition as Predictor of Exercise Therapy Outcome in Peripheral Arterial Disease

for Sarcopenia

Sponsor: Nemocnice AGEL Trinec-Podlesi a.s.

Sex: All·Age: 18+

Code: NCT07433309

Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone in Europe

for Peripheral Arterial Disease

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT07472439

Revascularization With Modification Using Definitive IVL and Serration Remodeling for Optimal Lumen

for Peripheral Artery Disease

Sponsor: Cagent Vascular LLC

Sex: All·Age: 18+

Code: NCT07575568

Radial Access Data in Vascular Interventions Registry

for Radial Artery Occlusion

Sponsor: Mersin Medicalpark Hastanesi

Sex: All·Age: 18+

Code: NCT07614386

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REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical Center

for Peripheral Arterial Disease

1 site in Knoxville

Sponsor: University of Tennessee Graduate School of Medicine

Sex: All·Age: 18+

Code: NCT07223437

Apply to this trial

EVERO Drug-coated Balloon (DCB) Randomized Trial

for Peripheral Vascular Disease

5 sites incl. Gainesville

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT07144150

Apply to this trial

Near Infrared Spectroscopy Imaging of Change in Tissue Oxygenation to Assess Peripheral Artery Disease

for Peripheral Arterial Disease

Sponsor: Kent Imaging Inc

Sex: All·Age: 21 - 99

Code: NCT07397494

an Observational Study Evaluting the Effectiveness and Safety of DKutting LL Noval Scoring Balloon Angioplasty for Vessel Preparation Facilitated by IVUS on the Lower Limb Ischemia Patients With Calcified Lesions

for Femoral Artery Stenosis

Sponsor: The First Affiliated Hospital of Dalian Medical University

Sex: All·Age: 18 - 85

Code: NCT07397390

Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System

for Venous Embolism of Lower Extremities (Diagnosis)

3 sites incl. Washington D.C.

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT07335341

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Tele-assessment and Face-to-face Assessment of the 30-second Sit-stand Test in Peripheral Artery Disease

for Peripheral Arterial Disease

Sponsor: Izmir Democracy University

Sex: All·Age: 18 - 65

Code: NCT07497360

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The Value of Super-resolution Ultrasound Imaging for Peripheral Artery Disease

for Peripheral Artery Disease

Sponsor: Peking University First Hospital

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07374601

Apply to this trial

Randomized Clinical Trial for Ewing Amputation in the VA

for Peripheral Arterial Disease

3 sites incl. Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT05437562

Apply to this trial

Road Mapping Guided Puncture Versus Ultrasound Guided Puncture During Retrograde Angioplasty Feasibility and Safety

for Peripheral Arterial Disease

Sponsor: Sohag University

Sex: All·Age: 18+

Code: NCT07427108

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Evaluation of Safety, Tolerability and Preliminary Efficacy of Etrinabdione in Patients With Peripheral Arterial Disease

for Peripheral Arterial Disease

Sponsor: VivaCell Biotechnology España

Sex: All·Age: 50 - 85

Code: NCT06774040·Phase 2

Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries

for Peripheral Arterial Disease

6 sites incl. Dallas

Sponsor: Baylor Research Institute

Sex: All·Age: 18+

Code: NCT07353905

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Prevalence of Obstructive Sleep Apnea in Patients With Peripheral Arterial Occlusive Disease

for Peripheral Artery Disease

Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Sex: All·Age: 18+

Code: NCT07283289

Apply to this trial

Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

for Peripheral Arterial Disease

32 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07223593·Phase 3

Apply to this trial

Vascular Trial Associated Registry Pilot

for Peripheral Arterial Disease

2 sites incl. Detroit

Sponsor: Corewell Health West

Sex: All·Age: 45+

Code: NCT07076082·Phase 4

Apply to this trial

Impact of Virtual Reality on Patient Pain During Lower Limb Revascularization Via Endovascular Surgery Under Local Anesthesia With Sedation

for Peripheral Arterial Disease

Sponsor: Poitiers University Hospital

Sex: All·Age: 18+

Code: NCT07181434

Mechanistic Study of Anti-Platelet Therapy in Atherosclerosis

for Peripheral Arterial Disease

Sponsor: Guy's and St Thomas' NHS Foundation Trust

Sex: All·Age: 18+

Code: NCT07169513

Truway Diagnostic Tools in Primary Care

for Chronic Disease

1 site in New York

Sponsor: Truway Health, Inc.

Sex: All·Age: All ages

Code: NCT07209527·EARLY_Phase 1

Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and Progression: the Prospective VASCUL-AID Study

for Abdominal Aorta Aneurism

Sponsor: Amsterdam UMC

Sex: All·Age: 40 - 90

Code: NCT07187700

Advanta VXT and Flixene PMCF Registry

for Peripheral Arterial Disease

1 site in Boston

Sponsor: Atrium Medical Corporation

Sex: All·Age: 18+

Code: NCT07161583

Apply to this trial

Improving Mobility After Revascularization in Peripheral Artery Disease

for Peripheral Artery Disease

7 sites incl. Tucson

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06686121·Phase 3

Apply to this trial

Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging

for Peripheral Arterial Disease

Sponsor: University of Edinburgh

Sex: All·Age: 18+

Code: NCT07472049

Apply to this trial

Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee

for Peripheral Artery Disease

2 sites incl. Houma

Sponsor: Mercator MedSystems, Inc.

Sex: All·Age: 18+

Code: NCT04433572·Phase 3

Apply to this trial

Safety and Efficacy of Chocolate Balloon Catheter in Peripheral Arterial Disease (CHOCO-PAD)

for Peripheral Arterial Disease

Sponsor: First People's Hospital of Hangzhou

Sex: All·Age: 18 - 80

Code: NCT06933992

Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

for Peripheral Arterial Disease

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06308562

Apply to this trial

Post-Market Study of ZENFLEX Pro Stent for Femoropopliteal Artery Lesions

for Peripheral Arterial Disease

Sponsor: Zhejiang Zylox Medical Device Co., Ltd.

Sex: All·Age: 18 - 80

Code: NCT07049120

Personalised Multicomponent Exercise Programme in Peripheral Arterial Disease

for Peripheral Arterial Disease

Sponsor: University of Trás-os-Montes and Alto Douro

Sex: Male·Age: 18+

Code: NCT06410521

Apply to this trial

Post-market Registry Study on the Safety and Efficacy of ZENFLEX Pro™ Peripheral Drug-eluting Stent System for Femoropopliteal Artery Lesions

for Peripheral Arterial Disease

Sponsor: MDCECRO LLC

Sex: All·Age: 18 - 80

Code: NCT07122167

Apply to this trial

Improving Walking Performance in Patients With Peripheral Artery Disease Through Wearable Activity Trackers

for Peripheral Artery Disease

Sponsor: Chinese University of Hong Kong

Sex: All·Age: All ages

Code: NCT07012070

Apply to this trial

Effects of Carnosine In Patients With Peripheral Arterial Disease Patients

for Peripheral Arterial Disease

3 sites in Louisville

Sponsor: Shahid Baba

Sex: All·Age: 40 - 80

Code: NCT06480760·Phase 1, Phase 2

Apply to this trial

Heat Therapy and Peripheral Artery Disease

for Peripheral Arterial Disease

Sponsor: Manchester Metropolitan University

Sex: All·Age: 18+

Code: NCT06827691

Post-Market Evaluation of Active Thrombectomy and Proximal Aspiration During Lower Extremity Tibial Interventions

for Peripheral Arterial Disease

Sponsor: Protexa Endovascular, Inc.

Sex: All·Age: 18+

Code: NCT06929832

Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention

for Peripheral Arterial Disease

3 sites incl. Beachwood

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 18 - 99

Code: NCT06544135

Apply to this trial

Study on PAD and CAS Based on Omics and Imaging

for Peripheral Artery Disease

Sponsor: Yijie Ning

Sex: All·Age: 18 - 85

Code: NCT06917547

Local or Systemic Effects: Mechanisms Related to Arm Crank Exercise - Comparison Between Individuals With and Without PAD

for Peripheral Arterial Disease

Sponsor: University of Nove de Julho

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06828172

Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease

for Peripheral Arterial Disease

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06952543

Apply to this trial

A Study of SRSD107 in Participants With Chronic Coronary and/or Peripheral Arterial Disease

for Coronary Artery Disease (CAD)

Sponsor: Sirius Therapeutics Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07318155·Phase 2

Apply to this trial

Response to Exercise and Nitric Oxide in PAD

for Peripheral Artery Disease

2 sites in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06657976·Phase 2

Apply to this trial

The Effectiveness of Covered Stent Viabahn and Drug-coated Balloon for Complex Femoropopliteal Artery Lesions

for Peripheral Arterial Disease

Sponsor: First Affiliated Hospital of Jinan University

Sex: All·Age: 18+

Code: NCT06752954

Prospective, Multicenter, Single-Arm Observational Study to Confirm the Safety and Clinical Performance of the Oscar Peripheral Multifunctional Catheter for the Dilatation of Lesions in the Femoral, Popliteal and Infrapopliteal Arteries (BIO-OSCAR First)

for Peripheral Arterial Disease

Sponsor: Biotronik AG

Sex: All·Age: 18+

Code: NCT06758921

Apply to this trial

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

for Peripheral Arterial Disease

1 site in Omaha

Sponsor: University of Nebraska

Sex: All·Age: 19 - 89

Code: NCT06480786

Apply to this trial

Peripheral artery disease clinical trials — common questions

Are peripheral artery disease clinical trials free to join?

Yes. Participating in a peripheral artery disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a peripheral artery disease clinical trial?

Each peripheral artery disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a peripheral artery disease trial near me?

Use the location controls above. We'll show recruiting peripheral artery disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many peripheral artery disease trials are recruiting right now?

We're currently tracking roughly 68 recruiting peripheral artery disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Peripheral artery disease trials by city

Chicago, IL Omaha, NE Boston, MA Gainesville, FL Birmingham, AL Detroit, MI Indianapolis, IN Milwaukee, WI Oklahoma City, OK Aurora, CO Cleveland, OH Columbus, OH

Related specialties

Cardiology Vascular medicine