Tobacco / nicotine use Clinical Trials

Recruiting tobacco / nicotine use studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat tobacco / nicotine use. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting tobacco / nicotine use studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting tobacco / nicotine use trials

Within

A Mindfulness-based Intervention for Sexual Assault Survivors

for Alcohol Misuse

1 site in Atlanta

Sponsor: Georgia State University

Sex: All·Age: 18 - 24

Code: NCT07515586

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

for Tobacco Use Disorder

1 site in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07714200

Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea

for Cigarette Smoking

Sponsor: Sung-il Cho

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT07755891

Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder

for Opioid Use Disorder

2 sites in Pittsburgh

Sponsor: Payel Roy

Sex: All·Age: 22 - 70

Code: NCT07770555

Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care

for Smoking

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06839729·Phase 1

Chatbot for Online Support Groups to Treat Tobacco Addiction

for Tobacco Dependence

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06952725

THCV Treatment for Smokers

for Tobacco Use Disorder

Sponsor: University of California, Los Angeles

Sex: All·Age: 21 - 65

Code: NCT07636356·Phase 2

ChatGPT-Supported Text Messaging Program for Smoking Cessation

for Smoking Cessation

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07079306

Facilitation to Increase Tobacco Treatment

for Serious Mental Illness

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07455526

Evaluation of the Efficacy of QUITOXIL® in Smoking Cessation

for Tobacco Use Disorder

Sponsor: KLAVA Innovation

Sex: All·Age: 18 - 65

Code: NCT07722832

A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products

for Smoking Behaviors

Sponsor: RAI Services Company

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT07739797

Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking

for Nicotine Dependance

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT07789132

Remote Interventions for Menthol Cigarette Use

for Cigarette Smoking

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07356297

A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

for Nicotine Dependence

1 site in Seattle

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06909500

Apply to this trial

Using Smartwatches to Monitor Smoking in Real-life Situations

for Smoking

1 site in Kansas City

Sponsor: National Institute on Minority Health and Health Disparities (NIMHD)

Sex: All·Age: 21 - 120·Accepts healthy volunteers

Code: NCT07067151

Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

for Obesity

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07224087·Phase 1

A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

for Obesity

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07398404·Phase 1, Phase 2

LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School

for Substance-related Disorders

Sponsor: Prevention Strategies, LLC

Sex: All·Age: 15 - 21·Accepts healthy volunteers

Code: NCT07655609

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

for Tobacco Use Cessation

1 site in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07694492

Automating Tobacco Cessation in Primary Care

for Tobacco Use

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07735286

Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in Dhaka

for Tobacco Use

Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh

Sex: All·Age: 18+

Code: NCT07746492

Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty

for Wound Surgical

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07770633

Effectiveness of Oral Nicotine Pouches as a Cessation Tool Among Adult Tobacco Users in Pakistan

for Tobacco Cessation

Sponsor: Cyntax Health Projects PVT LTD

Sex: All·Age: 18 - 65

Code: NCT07785479

Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation

for Smoking Cessation

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07789496

Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study

for Cannabis Use Disorder

1 site in San Bernardino

Sponsor: Loma Linda University

Sex: All·Age: 18+

Code: NCT07001371

Smoking Cessation Program for Lao People With HIV

for Smoking Cessation

Sponsor: University of Oklahoma

Sex: All·Age: 18+

Code: NCT07014605

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

for Nicotine Dependence

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07145866·Phase 4

Apply to this trial

Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults

for HIV

3 sites incl. Boise

Sponsor: Seattle Institute for Biomedical and Clinical Research

Sex: All·Age: 18+

Code: NCT07507435

Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients

for Tobacco Use

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07734727

Libre Del Cigarrillo: Development of an mHealth Smoking Cessation App to Extend Reach of a Validated Smoking Cessation Intervention for Spanish-speaking Smokers

for Smoking Cessation

1 site in Tampa

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07754448

The Effect of Motivational Interviewing on Smoking Behavior Among Nursing Students

for Tobacco Use

Sponsor: Meral Feratoğlu Research

Sex: All·Age: 18+

Code: NCT07758998

A Study to Evaluate the Efficacy and Safety of AXS-05 for Smoking Cessation in Adults

for Smoking Cessation

9 sites incl. Little Rock

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT07766655·Phase 3

Apply to this trial

Contingency Management to Promote Smoking Cessation: A Pilot Randomized Clinical Trial

for Smoking Cessation

1 site in Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+

Code: NCT07685899

Varenicline for Smoking Reduction in Veterans Not Ready To Quit

for Veterans

3 sites incl. San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT06966362·Phase 4

Apply to this trial

Pain and Smoking Study 2

for Smoking

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06442514

LLM Intervention for Tobacco in Underserved Populations (LIFT-UP)

for Smoking Cessation

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT07620301

Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya

for HIV

Sponsor: University of Chicago

Sex: All·Age: 18 - 80

Code: NCT06790342·Phase 3

A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

for Smoking

9 sites incl. Brandon

Sponsor: RAI Services Company

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT07710820

Apply to this trial

Telegram Messenger Support for Smoking Cessation After Heart Attack

for Myocardial Infarction (MI)

Sponsor: ITMO University

Sex: All·Age: 18+

Code: NCT07230249

Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

for Cigarette Addiction

1 site in Columbus

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07564648

Puff Topography and Sensory Effects Across IQOS Device Generations

for Nicotine Dependence

Sponsor: American University of Beirut Medical Center

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07712887

Apply to this trial

Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

for Smoking Cessation

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07099638·Phase 2

Apply to this trial

Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

for Nicotine Use Disorder

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26

Code: NCT06837220

Apply to this trial

Sex Differences in E-Cigarette Perception

for Nicotine Dependence

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 21 - 44·Accepts healthy volunteers

Code: NCT07398976

Impact of Electronic Cigarette Temperature and Solvent on Biomarkers

for Oxidative Stress

1 site in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 21+

Code: NCT07612696

Abuse Liability of Four Modern Oral Nicotine Products

for Smoking

Sponsor: RAI Services Company

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT07685795

Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

for Tobacco Use Disorder

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07425119

Apply to this trial

My Path to Quit Tobacco

for Smoking Cessation

5 sites incl. Phoenix

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07419425·Phase 4

Apply to this trial

Adaptive Mobile Interventions to Reduce Cancer Risk Behaviors

for Smoking Cessation

1 site in Baltimore

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07585357

Apply to this trial

Smoking Cessation Counseling Performance Among Medical Interns

for Smoking Cessation

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07650721

Apply to this trial

Promoting Smoking Cessation in the Community Via "Quit to Win" Contest 2026: Engagement-Focused GenAI-based Chatbot for Real-Time Smoking Cessation Support

for Smoking Cessation

Sponsor: The University of Hong Kong

Sex: All·Age: 18+

Code: NCT07649044

Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke

for Smoking Cessation

Sponsor: The University of Hong Kong

Sex: All·Age: 18+

Code: NCT07649018

Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum

for Perinatal

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: Female·Age: 18+

Code: NCT07489443

Apply to this trial

Abuse Liability of Two Modern Oral Nicotine Pouched Products

for Smoking

Sponsor: RAI Services Company

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT07595055

PASCAL Feasibility Study

for Smoking Cessation

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 21+

Code: NCT07301151

Apply to this trial

Multi-Site Trial of Tirzepatide for Smoking Cessation

for Smoking Cessation

4 sites incl. Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 21 - 65

Code: NCT07602699·Phase 2

Apply to this trial

Smoking Cessation With Wearables to Improve General, Oral Health and Quality of Life

for Smoking ( Cigarette)

Sponsor: University of Salerno

Sex: All·Age: 18+

Code: NCT07593742

3A-OR Very Brief Tobacco Cessation Intervention in Primary Care

for Smoking Cessation

Sponsor: Aydin Adnan Menderes University

Sex: All·Age: 15+

Code: NCT07609199

Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors

for Smoking Cessation

1 site in Tampa

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07447635

Apply to this trial

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

for Smoking

7 sites incl. Maitland

Sponsor: RAI Services Company

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT07598136

Apply to this trial

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Tobacco / nicotine use clinical trials — common questions

Are tobacco / nicotine use clinical trials free to join?

Yes. Participating in a tobacco / nicotine use clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a tobacco / nicotine use clinical trial?

Each tobacco / nicotine use study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a tobacco / nicotine use trial near me?

Use the location controls above. We'll show recruiting tobacco / nicotine use trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many tobacco / nicotine use trials are recruiting right now?

We're currently tracking roughly 175 recruiting tobacco / nicotine use trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Tobacco / nicotine use trials by city

San Francisco, CA Boston, MA Oklahoma City, OK Chicago, IL Los Angeles, CA Salt Lake City, UT Tampa, FL Birmingham, AL Columbus, OH Gainesville, FL Madison, WI Portland, OR

Related specialties

Behavioral health Addiction medicine