As of July 2026, 7 paid clinical trials are recruiting for ENT in Irvine, California. ENT (otolaryngology) trials evaluate new treatments for hearing loss, swallowing disorders, and head and neck cancers — covering pharmacologic, surgical, and rehabilitative approaches. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Irvine has approximately 358 recruiting research studies across a wide range of therapeutic areas. California hosts a dense network of world-class research institutions, including UC San Diego Health, Stanford Medicine, UCLA Health, UCSF, City of Hope, and Scripps Research. The state's thriving biotech corridor and diverse patient population make it a national hub for both early-phase and late-phase clinical research.
Researchers run research studies in Irvine, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| City of Hope at Irvine Lennar | Stage IV Lung Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | 57 |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Stage IV Colorectal Cancer AJCC v8, Metastatic Malignant Solid Neoplasm, Stage III Laryngeal Cancer AJCC v8 | 54 |
| University of California, Irvine | Alopecia Areata, Alzheimer Disease, Amyotrophic Lateral Sclerosis | 34 |
| University of California Irvine | Acute Decompensated Heart Failure, Age-related Macular Degeneration (AMD), Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV) | 19 |
| Kaiser Permanente-Irvine | Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer, Ovarian Carcinoma | 18 |
| City of Hope Orange County Lennar Foundation Cancer Center | Multiple Myeloma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 10 |
| City of Hope - Orange County Lennar Foundation Cancer Center | Breast Cancer, Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer, Non Small Cell Lung Cancer | 10 |
| City of Hope | Advanced Hodgkin Lymphoma, Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma | 8 |
| Irvine Clinical Research | Major Depressive Disorder, Alzheimer Disease, Alzheimer's Disease | 6 |
| Beckman Laser Institute and Medical Clinic | Abnormal Vascular Flow, Dermatologic Diseases, Gingivitis | 4 |
| Chao Family Comprehensive Cancer Center and Ambulatory Care | Endometrial Cancer, Breast Cancer, Cachexia | 4 |
| Hoag Memorial Hospital Presbyterian | Prostate Cancer, B7H3, Castration Resistant Metastatic Prostate Cancer | 4 |
| University of California - Irvine Medical Center | Huntington's Disease, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Pompe Disease | 4 |
| City of Hope at Orange County Lennar Foundation Cancer Center | Gastric Adenocarcinoma, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma | 4 |
| City of Hope - Lennar | Anemia, KRAS G12C-mutated Solid Tumors, Lung Cancer, KRAS, NRAS, HRAS-mutated NSCLC | 3 |
| Hoag Hospital Irvine | Breast Cancer, Breast Cancer Metastatic, Breast Neoplasm | 3 |
| Hoag Memorial Hospital | Esophageal Cancer, Gastric Cancer (GC), Gastroesophageal Junction | 3 |
| Irvine Center for Clinical Research | Alzheimers Disease, Alzheimer's Disease | 3 |
| Susan Samueli Integrative Health Institute | Fibromyalgia, Hypertension, Mild to Moderate Hypertension | 3 |
| UC Irvine | Advanced Adenocarcinoma, Diabetes Mellitus Type 2, Neutropenia | 3 |
| Univ of California, Irvine- Gavin Herbert Eye Institute | Amblyopia | 3 |
| University of California at Irvine | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 3 |
| City of Hope Lennar Foundation Cancer Center | Carcinoma, Small Cell Lung, Lung Neoplasms, Small Cell Cancer Of The Lung | 3 |
| Clinical Study Site | Metastatic Colorectal Cancer (CRC), Non-Small Cell Lung Cancer | 2 |
| ATP Clinical Research Inc. | Lewy Body Dementia Psychosis | 2 |
Recruiting trials in Irvine grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Clinical trials in California are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. In addition, California-specific protections such as the California Consumer Privacy Act (CCPA) and the Confidentiality of Medical Information Act (CMIA) impose stringent data-privacy requirements on research involving California residents.
Hipa.ai aggregates every recruiting study in Irvine from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
There are approximately 358 recruiting clinical trials in Irvine, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Irvine compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Irvine include Breast Cancer (10), Anatomic Stage IV Breast Cancer AJCC v8 (7), Endometrial Cancer (7), Multiple Myeloma (7), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Irvine on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Irvine include City of Hope at Irvine Lennar, UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, University of California, Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Irvine are Cancer & tumors (180), Neurology & pain (22), Diabetes & metabolic (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.