Paid Clinical Trials in Orange, CA
As of June 2026, 541 paid clinical trials are recruiting in Orange, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Orange offers studies at sites including Children's Hospital of Orange County for conditions such as Breast Cancer, Hepatocellular Carcinoma, Acute Myeloid Leukemia, Colorectal Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Orange
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·Clear filters·↓ Download CSVAbout research studies in Orange
Orange has approximately 541 recruiting research studies across a wide range of therapeutic areas. California hosts a dense network of world-class research institutions, including UC San Diego Health, Stanford Medicine, UCLA Health, UCSF, City of Hope, and Scripps Research. The state's thriving biotech corridor and diverse patient population make it a national hub for both early-phase and late-phase clinical research.
Top Research Study Locations in Orange
Researchers run research studies in Orange, CA at 50 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Children's Hospital of Orange County | Recurrent Malignant Solid Neoplasm, B Acute Lymphoblastic Leukemia, Neuroblastoma | 77 |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Malignant Solid Neoplasm, Stage IV Colorectal Cancer AJCC v8 | 65 |
| University of California Irvine | Amyotrophic Lateral Sclerosis, Anticoagulants, Carcinoma, Non-Small-Cell Lung | 28 |
| University of California Irvine Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 22 |
| University of California, Irvine | Myasthenia Gravis, Parkinson Disease, AChR Myasthenia Gravis | 21 |
| Chao Family Comprehensive Cancer Center, University of California, Irvine | Hepatocellular Carcinoma, Myelofibrosis, Pancreatic Cancer | 15 |
| UC Irvine Medical Center | Advanced Breast Cancer, Advanced Gastric Cancer, Advanced Liver Cancers | 14 |
| UC Irvine Health | B-cell Malignancy, Cachexia, Cervical Cancer | 13 |
| Saint Joseph Hospital - Orange | Anatomic Stage III Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma | 11 |
| NRC Research Institute | Bipolar Disorder, Bipolar I Disorder, Autism Spectrum Disorder | 11 |
| Chao Family Comprehensive Cancer Center University of California, Irvine | Melanoma (Skin), Cervical Cancer, Chronic Myeloid Leukemia | 8 |
| University of California, Irvine Medical Center | Cancer, Lung, Cardiovascular Diseases, Colorectal Cancer; Lung Cancer | 8 |
| ATP Clinical Research | Bipolar Disorder, Depressive Disorder, Major, Bipolar Depression | 8 |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 8 |
| Knowledge Research Center | Ulcerative Colitis, Ankylosing Spondylitis, Autoimmune Diseases | 7 |
| Children's Hospital Orange County | ALL, AML, Acute Undifferentiated Leukemia | 6 |
| UCI Health | Heart Failure, Cancer, Crohn's Disease | 6 |
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Gastric Cancer, Triple Negative Breast Neoplasms, Acute Myeloid Leukemia | 5 |
| Chao Family Comprehensive Cancer Center | Advanced Clear Cell Renal Cell Carcinoma, Chronic Lymphocytic Leukemia, Endometrial Cancer | 4 |
| Chao Family Comprehensive Cancer Center, University of California Irvine | Allogeneic Stem Cell Transplantation, Breast Cancer, Colorectal Cancer | 4 |
| Children's Hospital of Orange County (CHOC) | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Anti-myostatin | 4 |
| UCI Medical Center | Deep Venous Thrombosis, Locally Advanced Solid Tumor, Metastatic Solid Tumor | 4 |
| Children's Hospital of Orange County Main Campus - Orange | Acute Myeloid Leukemia, Idiopathic Short Stature, Noonan Syndrome | 3 |
| Clinical Trial Site | Cerebral Amyloid Angiopathy, GNE Myopathy, Generalized Myasthenia Gravis | 3 |
| Clinnova Research Solutions | Liver Fibrosis, Metabolic Dysfunction Associated Steatohepatitis, Metabolic Dysfunction Associated Steatohepatitis (MASH) | 3 |
| Neurocrine Clinical Site | Major Depressive Disorder, Bipolar Disorder, Schizoaffective Disorder | 3 |
| St. Joseph Hospital | Central Line Associated Blood Stream Infections (CLABSI), Glioblastoma, Prostate Cancer | 3 |
| Univ Cali Irvine ALS Neuromuscular | Generalized Myasthenia Gravis, IC-MPGN | 3 |
| University of California - Irvine | Anaplastic Lymphoma Kinase (ALK) Positive, Myositis, Neoplasm Metastasis | 3 |
| University of California Irvine Health | Chronic Graft-Versus-Host Disease (cGVHD), Focal Onset Seizures, Peripartum Cardiomyopathy, Postpartum | 3 |
| UC Irvine | Autoimmune Encephalitis, Encephalitis, Overactive Bladder (OAB) | 3 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Ascendis Investigational Site | Growth Hormone Deficiency | 2 |
| Center for Inherited Blood Disorders | Hemophilia A | 2 |
| Children's Hospital, Orange County | Bladder and Bowel Dysfunction, Infant, Extremely Premature, Intensive Care Units, Neonatal | 2 |
| Childrens Hospital of Orange County | Diabetes Mellitus, Type 1, Epilepsy in Children, Executive Dysfunction | 2 |
| Clinical Study Site | Glycogen Storage Disease Type Ia, Metastatic Colorectal Cancer (CRC) | 2 |
| Hoag Orthopedics | Cutibacterium Acnes Contamination, Degenerative Disc Disease, Degenerative Scoliosis | 2 |
| Local Institution - 1001 | Alzheimer Disease, Locally Advanced Solid Tumors, Metastatic Solid Tumors | 2 |
| St. Joseph Hospital Center for Cancer Prevention and Treatment | Carcinoma, Non-Small-Cell Lung, Chronic Graft Versus Host Disease, Chronic Lymphocytic Leukemia | 2 |
| St. Joseph Hospital Orange | AMI Cardiogenic Shock, Melanoma | 2 |
| TG Therapeutics Investigational Trial Site | Relapsing Multiple Sclerosis, Multiple Sclerosis | 2 |
| UC Irvine Health Chao Family Comprehensive Cancer Center | AML With Mutated NPM1, Acute Myeloid Leukemia, KMT2Ar | 2 |
| UC Irvine Health, Chao Family Comprehensive Cancer Center | Advanced Melanoma, Breast Cancer | 2 |
| UC Irvine Health-Chao Family Comprehensive Cancer Center | Adenoid Cystic Carcinoma, Breast Cancer, Endometrial Cancer | 2 |
| UCI Center for Clinical Research | Degenerative Disc Disease, Proteinuric Kidney Disease | 2 |
| UCI Chao Family Comprehensive Cancer Center | Leukemia, Myeloid, Acute, Non-small Cell Lung Cancer (NSCLC) | 2 |
| UCI Health Chao Family Comprehensive Cancer Center | Cancer, Endometrioid Ovarian Cancer, Fallopian Tube Cancer | 2 |
| University of California-Irvine | Antiphospholipid Syndrome (APS), Behçet's Syndrome (BS), Bullous Pemphigoid (BP) | 2 |
| St. Joseph Hospital-The Center for Cancer Prevention and Treatment | Non-small Cell Lung Cancer, Non Small Cell Lung Cancer | 2 |
Active & Upcoming Studies in Orange (2026)
Recruiting trials in Orange grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (220 active studies)
- Testing the Safety of Anti-Cancer Drug, CX-5461 (Pidnarulex), in Treating Lymphoma With Specific Changes in the MYC Gene · Phase 1, Phase 2 · National Cancer Institute (NCI)
- Utilization of Flotufolastat 18F PET for Post-Focal Therapy Prostate Cancer Evaluation · Phase 2 · University of California, Irvine
Cardiovascular (22 active studies)
- Optimal Ventilation for Cardiac Arrest · Children's Hospital of Philadelphia
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
Neurology & pain (20 active studies)
- Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study · University of California, Irvine
- Musical Mindfulness for Pain in the ED Waiting Room · University of California, Irvine
Mental health & behavior (19 active studies)
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) · Phase 2 · Tonix Pharmaceuticals, Inc.
- A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder · Phase 2 · AbbVie
Diabetes & metabolic (13 active studies)
- A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D) · Phase 3 · Pfizer
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
Pediatric (7 active studies)
- Pediatric Down Syndrome Post-Approval Study · Inspire Medical Systems, Inc.
- Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy · Children's Hospital Medical Center, Cincinnati
Vaccines (2 active studies)
- Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS) · Children's Hospital of Orange County
- SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry · Massive Bio, Inc.
Eye & vision (2 active studies)
- A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy · Astellas Pharma Global Development, Inc.
- The Myelin Disorders Biorepository Project · Children's Hospital of Philadelphia
Common conditions studied in Orange
- Breast Cancer (11 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Hepatocellular Carcinoma (9 active studies). Recruiting Hepatocellular Carcinoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Acute Myeloid Leukemia (7 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Colorectal Cancer (7 active studies). Colorectal cancer trials explore novel chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors.
- Endometrial Cancer (7 active studies). Recruiting Endometrial Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Gastric Cancer (7 active studies). Recruiting Gastric Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Orange
- University of California, Irvine
- National Cancer Institute (NCI)
- Children's Oncology Group
- AstraZeneca
- Merck Sharp & Dohme LLC
Local regulations and guidelines
Clinical trials in California are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. In addition, California-specific protections such as the California Consumer Privacy Act (CCPA) and the Confidentiality of Medical Information Act (CMIA) impose stringent data-privacy requirements on research involving California residents.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Orange. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Orange
Hipa.ai aggregates every recruiting study in Orange from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Orange?
There are approximately 541 recruiting clinical trials in Orange, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orange pay participants?
Most recruiting trials in Orange compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orange?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orange?
The most common conditions under active study in Orange include Breast Cancer (11), Hepatocellular Carcinoma (9), Acute Myeloid Leukemia (7), Colorectal Cancer (7), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orange?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orange on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orange?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orange?
Recruiting research sites in Orange include Children's Hospital of Orange County, UC Irvine Health/Chao Family Comprehensive Cancer Center, University of California Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orange right now?
The largest active categories in Orange are Cancer & tumors (220), Cardiovascular (22), Neurology & pain (20). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.