Cirrhosis / liver disease Clinical Trials

Recruiting cirrhosis / liver disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat cirrhosis / liver disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting cirrhosis / liver disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting cirrhosis / liver disease trials

Within

Erlotinib for Hepatocellular Carcinoma Chemoprevention

for Cirrhosis, Liver

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT04172779·Phase 2

Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE)

for Hepatic Encephalopathy

3 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT07528690·Phase 2

Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy

for Cirrhosis

Sponsor: Hospital do Divino Espírito Santo de Ponta Delgada

Sex: All·Age: 18+

Code: NCT07668778·Phase 3

Development of a Predictive Score for the Risk of Infection in the Immediate Post-liver-transplant Period

for Cirrhosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07647978

Impact of Propranolol on the Prognosis of Patients With Decompensated Cirrhosis and MELD Score > 9

for Cirrhosis

Sponsor: General Hospital of Shenyang Military Region

Sex: All·Age: 18+

Code: NCT07652203

Personalized Nutritional Intervention in Patients Undergoing TIPS Insertion for Refractory Ascites to Prevent Overt Hepatic Encephalopathy

for Cirrhosis

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All·Age: 18 - 70

Code: NCT07634237

Bumetanide vs. Furosemide in Cirrhosis

for Cirrhosis

1 site in Salt Lake City

Sponsor: Stacy Johnson

Sex: All·Age: 18+

Code: NCT06941415·Phase 3

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4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis

for Cirrhosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07554183

Microplastics, Cirrhosis and Portal Hypertension

for Cirrhosis

Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Sex: All·Age: 18 - 70

Code: NCT07280390

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Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07585773

Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)

for Cirrhosis, Liver

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07585786

Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)

for Cirrhosis, Liver

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07588334

Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18 - 80

Code: NCT07588373

PSYLIVER-PILOTE: Involvement of the Autonomic Nervous System in Hepatocellular Carcinoma (HCC)

for Hepato Cellular Carcinoma

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07393074

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Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis

for Cirrhosis

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07029243

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DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis

for Cirrhotic Cardiomyopathy

Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Sex: All·Age: 18 - 65

Code: NCT07322237·Phase 4

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Observational Clinical Study on the Association Between Lactate-mediated Gut Microbiota Alterations and Disease Progression in Liver Cirrhosis.

for Cirrhosis

Sponsor: Zhujiang Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07455175

Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSD

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18+

Code: NCT07461532

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Efficacy of Apixaban in the Treatment of Portal Vein Thrombosis Occurring More Than One Year After LS

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18+

Code: NCT07461545

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Effect of Fufang Biejiaruangan Combined With Antiviral Therapy on the Incidence of Hepatocellular Carcinoma in Patients With Hepatitis B-related Cirrhosis: A Multicenter, Randomized, Placebo-controlled Study

for Cirrhosis, Liver

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 65

Code: NCT07481032

Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis

for Cirrhosis

Sponsor: Asian Institute Of Medical Sciences

Sex: All·Age: 18+

Code: NCT07521332·Phase 4

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Effect of Babao Dan Capsule Combined With Antiviral Therapy on the Incidence of Hepatocellular Carcinoma in Patients With Hepatitis B-related Cirrhosis

for HEPATITIS B CHRONIC

Sponsor: Nanfang Hospital, Southern Medical University

Sex: All·Age: 18 - 65

Code: NCT07544121

Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

for Advanced Hepatocellular Carcinoma

1 site in Chicago

Sponsor: Devalingam Mahalingam

Sex: All·Age: 18+

Code: NCT07042919·Phase 1, Phase 2

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Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection

for Cirrhosis

Sponsor: Northern Jiangsu People's Hospital

Sex: All·Age: 18+

Code: NCT07462091

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Copper Supplementation in Cirrhosis

for Cirrhosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07471542

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Albumin in Acute Variceal Bleeding

for Acute Variceal Bleeding

Sponsor: King George's Medical University

Sex: All·Age: 18 - 70

Code: NCT07395141·Phase 3

Cirrhotic and Non-cirrhotic Patients With Clinically Significant Portal Hypertension

for Cirrhosis, Liver

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07405749

Cohort Study of Chronic Liver Disease Complicated by Sepsis

for Cirrhosis

Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07465003

Liver Cirrhosis Complicated by Clinically Significant Portal Hypertension

for Portal Hypertension

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07365709

The Feasibility, Safety, and Efficacy of EUS-Guided PSE: A Cohort Study

for Cirrhosis

Sponsor: Qilu Hospital of Shandong University

Sex: All·Age: 18 - 80

Code: NCT07354789

Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI)

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

4 sites incl. Los Angeles

Sponsor: Kaiser Permanente

Sex: All·Age: 18+

Code: NCT07216859

Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis

for Cirrhosis, Liver

Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Sex: All·Age: 18 - 65

Code: NCT07286643

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Biannual Screening for HCC Offered to Patients With Cirrhosis. Introducing Surveillance for Hepatocellular Carcinoma (HCC) in the Central Denmark Region Using Ultrasound and Alpha-Fetoprotein to Reduce HCC-Related Mortality in Patients With Compensated Non-Viral Cirrhosis

for Hepatocellular Carcinoma (HCC)

Sponsor: University of Aarhus

Sex: All·Age: 40 - 79

Code: NCT07469319

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MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

Sponsor: Linkoeping University

Sex: All·Age: 18+

Code: NCT07312136

Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates

for End-Stage Liver Disease

Sponsor: Izmir Bakircay University

Sex: All·Age: 18 - 65

Code: NCT07414095

Apply to this trial

TIPS With or Without BCAA

for BCAA

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80

Code: NCT07281846

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Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide

for HBV

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07429864

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Statin and Beta Blocker Use in Patients With Decompensated Cirrhosis

for Decompensated Liver Cirrhosis

1 site in Charleston

Sponsor: CAMC Health System

Sex: All·Age: 18+

Code: NCT06764966·Phase 2

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Study of the Impact of HYPOglycaemia on Sarcopenia in CIRrhosis

for Cirrhosis

Sponsor: Centre Hospitalier Universitaire Dijon

Sex: All·Age: 18+

Code: NCT06948656

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DEFINITION OF THE GENOMIC LANDSCAPE OF MASLD

for Cirrhosis

Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07249112

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Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care

for Hepatic Insufficiency

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07343037

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Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study

for Cirrhosis

Sponsor: Centre Hospitalier Universitaire de Besancon

Sex: All·Age: All ages

Code: NCT06948565

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Affect of Melatonin on Sleep and Cognition in Cirrhosis

for Hepatic Encephalopathy

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT07046429

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The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

for Liver Diseases

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06871111·Phase 1

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The Impact of Transjugular Intrahepatic Portosystemic Shunt on Recompensation in Patients With Decompensated Liver Cirrhosis

for Cirrhosis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80

Code: NCT07172035

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Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis

for Cirrhosis

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT06932783

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HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

for Cirrhosis

2 sites in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05205954

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Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)

for Fragility

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT06911619

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Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and Survival

for Decompensated Cirrhosis

Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Sex: All·Age: 18 - 65

Code: NCT06431919

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mSEPT9 Biomarker for Predicting Hepatocellular Carcinoma Occurrence in Patients With Cirrhosis

for Hepatocellular Carcinoma (HCC)

Sponsor: Central Hospital, Nancy, France

Sex: All·Age: 18+

Code: NCT06778317

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Mechanism of TIPS to Improve Sarcopenia

for Sarcopenia

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80

Code: NCT06794853

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Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)

for Cirrhosis

Sponsor: Military University Hospital, Prague

Sex: All·Age: 18 - 75

Code: NCT07424963

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Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

for Acute Kidney Injury

1 site in New York

Sponsor: Giuseppe Cullaro, MD

Sex: All·Age: 18 - 70

Code: NCT06937307·Phase 2

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The Role of Serum AKR1B10 in Early Warning of Hepatocellular Carcinoma in Cirrhosis Patients

for Cirrhosis

Sponsor: The First Affiliated Hospital of University of South China

Sex: All·Age: 18 - 75

Code: NCT07147335

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Evaluation of Non-Invasive Tests for Metabolic Liver Disease

for Metabolic Associated Fatty Liver Disease

4 sites incl. Miami

Sponsor: Foundation for the National Institutes of Health

Sex: All·Age: 18 - 75

Code: NCT07122700

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Abbreviated Magnetic Resonance Imaging vs Ultrasound Surveillance for Liver Cancer dETection in People at High Risk of Developing Liver Cancer

for Cirrhosis

Sponsor: University of Oxford

Sex: All·Age: 18+

Code: NCT06658782

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CARPEUS : Effect of Carvedilol on the Portosystemic Gradient as Measured by Endoscopic Ultrasound

for Cirrhosis

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT06861075

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EUS-guided Portal Pressure Gradient (PPG) Measurement: a Potential Alternative to the Traditional HVPG

for Portal Hypertension

Sponsor: Fundacio Privada Mon Clinic Barcelona

Sex: All·Age: 18 - 85

Code: NCT06863012

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Predictors of Spontaneous Bacterial Peritonitis Among Patients with Cirrhosis

for Cirrhosis

Sponsor: Assiut University

Sex: All·Age: 18 - 70

Code: NCT06884306

Evaluation of Patient Care Support for Cirrhosis and/or Liver Transplants

for Cirrhosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT06544863

Apply to this trial

Cirrhosis / liver disease clinical trials — common questions

Are cirrhosis / liver disease clinical trials free to join?

Yes. Participating in a cirrhosis / liver disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a cirrhosis / liver disease clinical trial?

Each cirrhosis / liver disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a cirrhosis / liver disease trial near me?

Use the location controls above. We'll show recruiting cirrhosis / liver disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many cirrhosis / liver disease trials are recruiting right now?

We're currently tracking roughly 62 recruiting cirrhosis / liver disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Cirrhosis / liver disease trials by city

Boston, MA Cleveland, OH Chicago, IL Los Angeles, CA Ann Arbor, MI Indianapolis, IN San Francisco, CA Birmingham, AL La Jolla, CA

Related specialties

Gastroenterology Hepatology