Glioblastoma Clinical Trials

Recruiting glioblastoma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat glioblastoma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting glioblastoma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting glioblastoma trials

Within

Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform

for Glioblastoma Multiforme

Sponsor: Olympion Medical Center

Sex: All·Age: 18+

Code: NCT01777919·Phase 2

CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM)

for Glioblastoma

Sponsor: Crimson Biopharm Inc.

Sex: All·Age: 18+

Code: NCT04933422·Phase 1

NG101m Adjuvant Therapy in Glioblastoma Patients

for Glioblastoma Multiforme

1 site in Houston

Sponsor: NeuGATE Theranostics

Sex: All·Age: 18+

Code: NCT04373785·Phase 1, Phase 2

ctDNA-Guided Intraventricular Therapy for CNS Malignancies

for Leptomeningeal Disease

Sponsor: Alireza Mansouri

Sex: All·Age: 18 - 120

Code: NCT07689721

PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

for Glioblastoma

1 site in Los Angeles

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06448286·Phase 3

A Study for Cerebral Open Flow Microperfusion

for Glioma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07089758

Pilot Radioembolisation Clinical Trial Assessing Safety and Efficacy in Recurrent Glioma

for Recurrent Glioblastoma IDH Wildtype

Sponsor: Olivia Newton-John Cancer Research Institute

Sex: All·Age: 18+

Code: NCT07712770·EARLY_Phase 1

A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma

for Phase 1

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07579208·Phase 1

Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed Glioblastoma

for Glioblastoma

Sponsor: Beijing Tricision Biotherapeutics Inc

Sex: All·Age: 18 - 70

Code: NCT07715097·Phase 2

Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up

for Glioblastoma

Sponsor: Centre Paul Strauss

Sex: All·Age: 18+

Code: NCT07628257

A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma

for Glioblastoma

1 site in Chicago

Sponsor: Catalina Lee Chang

Sex: All·Age: 18+

Code: NCT07422896·Phase 1

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

for Newly Diagnosed Glioblastoma

1 site in Durham

Sponsor: Mustafa Khasraw, MBChB, MD, FRCP, FRACP

Sex: All·Age: 18+

Code: NCT04903795·Phase 1

Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas

for Glioblastoma

2 sites incl. Rochester

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07620548·Phase 2

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

for Meningioma

1 site in Nashville

Sponsor: Eben Rosenthal

Sex: All·Age: 18+

Code: NCT07493447·EARLY_Phase 1

Apply to this trial

A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma

for Glioblastoma

3 sites incl. Phoenix

Sponsor: Myosin Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07604285·Phase 1, Phase 2

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for Recurrent Glioblastoma

1 site in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 99

Code: NCT07416188·Phase 1, Phase 2

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Phase I Trial of pH Resections of GBM at VA

for Glioblastoma

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07218367·Phase 1

Oral Gallium Maltolate for Recurrent Glioblastoma

for Glioblastoma

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT07515924·EARLY_Phase 1

Exploratory Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Tumor Neoantigen-pulsed Autologous Dendritic Cell Injection (YS247, Beijing YSCell Biotech Co., Ltd. [Abbreviated as YS])in Patients With Recurrent or Progressive Glioblastoma

for Glioblastoma

Sponsor: Huanhu Hospital Affiliated to Tianjin Medical University

Sex: All·Age: 18 - 75

Code: NCT07678138

Vortioxetine for Newly Diagnosed Glioblastoma

for Glioblastoma

Sponsor: University of Zurich

Sex: All·Age: 18+

Code: NCT07284628·Phase 2

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Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma

for Recurrent Glioblastoma (WHO-Grade IV Glioma)

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 18 - 80

Code: NCT07648823·EARLY_Phase 1

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Imaging Acetadote Metabolism in Glioblastoma

for Glioblastoma

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT07387666·EARLY_Phase 1

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Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma

for Glioblastoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07392957·Phase 1, Phase 2

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Impact of Fluorescence-Guided Resection and Chemoradiotherapy on the Systemic Immune Response in Glioblastoma: A Kinetic Analysis of Immune Biomarkers.

for Glioblastoma

Sponsor: University Hospital, Lille

Sex: All·Age: 18+

Code: NCT07568782

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for Glioma

1 site in Iowa City

Sponsor: Kailin Yang, MD, PhD

Sex: All·Age: 18+

Code: NCT07541781·Phase 1

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Pharmacoscopy for Patients With Refractory Primary Brain Tumors

for Brain (Nervous System) Cancers

Sponsor: University of Zurich

Sex: All·Age: 18+

Code: NCT06804655·Phase 2

Pilot Study of Navigated Focused Ultrasound and Pembrolizumab in the Treatment of Recurrent WHO Grade 4 IDH-Wildtype Glioblastoma With Mismatch Repair Deficiency

for Glioblastoma

1 site in Cincinnati

Sponsor: Jennifer Leddon

Sex: All·Age: 18+

Code: NCT07385846·Phase 1

MRinRT: Swansea University and SWWCC Collaboration Study.

for Carcinoma

Sponsor: Swansea Bay University Health Board

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07365124

The EASE Study: Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced Cancer

for Advanced Solid Tumor Cancer

2 sites incl. Aurora

Sponsor: University of Colorado, Boulder

Sex: All·Age: 18+

Code: NCT07636200

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First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 Astrocytoma

for Astrocytoma

1 site in Minneapolis

Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All·Age: 18 - 75

Code: NCT07560865·Phase 1

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Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

for Glioblastoma (GBM)

1 site in Columbus

Sponsor: Trogenix ltd

Sex: All·Age: 18 - 70

Code: NCT07346144·Phase 1, Phase 2

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A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

for Glioblastoma Multiforme of Brain

3 sites incl. Tampa

Sponsor: Tetragon Biosciences Ltd

Sex: All·Age: 18+

Code: NCT07464925·Phase 1

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Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma

for Glioblastoma

Sponsor: Beta Emitting Accurate Monitored Systems

Sex: All·Age: 18+

Code: NCT07274397

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APT-weighted and Diffusion MRI for Characterizing Tumor Infiltration in High-Grade Gliomas

for High-Grade Glioma

Sponsor: IRCCS Ospedale San Raffaele

Sex: All·Age: 18+

Code: NCT07532031

Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant Tumors

for Pancreatic Cancer

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07552467

Apply to this trial

Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma

for Glioblastoma

Sponsor: CRISM Therapeutics LTD

Sex: All·Age: 18+

Code: NCT07356973·Phase 2

Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.

for High Grade Gliomas

Sponsor: The Cooper Health System

Sex: All·Age: 18 - 80

Code: NCT07439172·Phase 2

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

for Glioblastoma

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07003542·Phase 2

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Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)

for Glioblastoma

1 site in San Francisco

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 3 - 39

Code: NCT07389278·Phase 1, Phase 2

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

for Malignant Glioma

Sponsor: Beijing Biotech

Sex: All·Age: 18 - 75

Code: NCT07551336·Phase 1

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Contribution From PET-DOPA in Glioblastoma Re-irradiation - A Randomized Phase II Study

for Glioblastoma

Sponsor: Centre Paul Strauss

Sex: All·Age: 18+

Code: NCT05653635·Phase 2

Apply to this trial

Senicapoc and Perampanel for Newly Diagnosed Glioblastoma

for Glioblastoma

Sponsor: Aarhus University Hospital

Sex: All·Age: 18+

Code: NCT07284069·EARLY_Phase 1

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Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors

for Brain Tumor Adult

Sponsor: Medical University of Warsaw

Sex: All·Age: 18+

Code: NCT07411690

Apply to this trial

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

for Glioblastoma

Sponsor: Beijing Biotech

Sex: All·Age: 18 - 75

Code: NCT07480941·Phase 1

Apply to this trial

Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors

for Cancer

Sponsor: Essen Biotech

Sex: All·Age: 8 - 85

Code: NCT07410494·Phase 1, Phase 2

Apply to this trial

EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors

for Cancer

Sponsor: Essen Biotech

Sex: All·Age: All ages

Code: NCT07410676·Phase 1, Phase 2

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Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures

for Brain Tumor Adult

Sponsor: Medical University of Warsaw

Sex: All·Age: 18+

Code: NCT07413796

Apply to this trial

Clinical Trial Assessing the Efficacy and Safety of Dendritic Cell-Based Immunotherapy for Glioblastoma

for Glioblastoma

Sponsor: University of Sao Paulo General Hospital

Sex: All·Age: 18+

Code: NCT06749925·Phase 3

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

for Glioblastoma

11 sites incl. Boston

Sponsor: Alpheus Medical, Inc.

Sex: All·Age: 18 - 80

Code: NCT07225621·Phase 2

Apply to this trial

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

for Recurrent Glioblastoma

Sponsor: BioNTech SE

Sex: All·Age: 18 - 75

Code: NCT07297212·Phase 2

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Neoantigen-Pulsed Autologous Dendritic Cell Vaccine Combined With Temozolomide for Newly Diagnosed Glioblastoma

for Glioblastoma

Sponsor: ZSky Biotech Inc

Sex: All·Age: 18 - 75

Code: NCT07365280·Phase 2

Correlative Analysis Between Magnetic Resonance Spectroscopy (MRS) and Essential Clinicobiological Data in Glioblatoma Multiforme (GBM)

for Glioblastoma

Sponsor: Centre Hospitalier Universitaire, Amiens

Sex: All·Age: 18+

Code: NCT07211841

TTFields Plus FET-PET-Guided Stereotactic Radiosurgery Versus TTFields Alone for Recurrent Glioblastoma (Tarrget 2.0)

for Glioblastoma

Sponsor: Prof. Franciszek Lukaszczyk Memorial Oncology Center

Sex: All·Age: 18+

Code: NCT07668869

Apply to this trial

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for Amyloidosis

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07285044·Phase 2

Apply to this trial

OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour Patients

for Primary Brain Tumour

Sponsor: Royal College of Surgeons, Ireland

Sex: All·Age: 18+

Code: NCT07426848

Apply to this trial

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

for Glioblastoma

6 sites incl. Scottsdale

Sponsor: GT Medical Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07195591·Phase 3

Apply to this trial

Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO]

for Glioblastoma Multiforme

Sponsor: Copernicus Memorial Hospital

Sex: All·Age: 18 - 70

Code: NCT06466031

Apply to this trial

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

for Glioblastoma

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT06991101·Phase 2

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Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

for Recurrent Glioblastoma

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07209241·Phase 1

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Intensified Adjuvant Therapy for High-Risk Newly Diagnosed Glioblastoma With Subtotal Resection or Short-Term Progression

for Glioblastoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18+

Code: NCT07670026·Phase 2

Apply to this trial

Glioblastoma clinical trials — common questions

Are glioblastoma clinical trials free to join?

Yes. Participating in a glioblastoma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a glioblastoma clinical trial?

Each glioblastoma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a glioblastoma trial near me?

Use the location controls above. We'll show recruiting glioblastoma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many glioblastoma trials are recruiting right now?

We're currently tracking roughly 167 recruiting glioblastoma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Glioblastoma trials by city

San Francisco, CA Los Angeles, CA Boston, MA Cleveland, OH Miami, FL Aurora, CO Birmingham, AL Gainesville, FL Chicago, IL Detroit, MI Duarte, CA

Related specialties

Oncology Neuro-oncology