Metabolic syndrome Clinical Trials

Recruiting metabolic syndrome studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat metabolic syndrome. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting metabolic syndrome studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting metabolic syndrome trials

Within

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

for Cardiovascular Diseases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06320951·Phase 2

Theoretically Informed Behavioral Intervention

for HIV

1 site in Orange

Sponsor: Yale University

Sex: Male·Age: 18+

Code: NCT06580184

Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury

for Metabolic Syndrome

1 site in Gunnison

Sponsor: Gary Van Guilder

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06825143·EARLY_Phase 1

Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss

for Obesity

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06299644

Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud

for Normal Weight Obesity

Sponsor: Pomeranian Medical University Szczecin

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07358533

A Mediterranean Diet-Based Culinary Intervention in Adults With Metabolic Syndrome

for Metabolic Syndrome

Sponsor: Fundacion Clinic per a la Recerca Biomédica

Sex: All·Age: 30 - 60

Code: NCT07702695

Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial

for Metabolic Syndrome

Sponsor: University of Zadar

Sex: All·Age: 20+·Accepts healthy volunteers

Code: NCT07314957

Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome

for Metabolic Syndrome

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07218653·EARLY_Phase 1

Effects of Meal Macronutrients on Postprandial Lipids

for Nephrotic Syndrome

1 site in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 120

Code: NCT07313787·Phase 2

Atrial Cardiomyopathy in Patients With Cardiovascular-Kidney-Metabolic Syndrome: Non-invasive Characterization

for Cardiovascular-Kidney-Metabolic Syndrome

Sponsor: Grigore T. Popa University of Medicine and Pharmacy

Sex: All·Age: 18+

Code: NCT07697469

Clinical Safety Evaluation and Preliminary Efficacy Study of Subcutaneous Myografts Transplantation

for Metabolic Disease

Sponsor: National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China

Sex: All·Age: 18 - 80

Code: NCT07426068·EARLY_Phase 1

Evaluation of Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms After Bariatric Surgery in Body Weight Management

for Obesity, Morbid

Sponsor: Toros University

Sex: All·Age: 19 - 50

Code: NCT07643376

Comparative Effects of Carnivore and Mediterranean-style Diets on LDL Aggregation and Cardiometabolic Health

for Atherosclerosis Cardiovascular Disease

Sponsor: Liverpool John Moores University

Sex: All·Age: 30 - 60·Accepts healthy volunteers

Code: NCT07462871

Validation of the Snouda Metabolic Score for Phenotyping and Guiding Reversal in Type 2 Diabetes

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Salah Snouda

Sex: All·Age: 18+

Code: NCT07606872

Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)

for Obesity

Sponsor: Hallym University

Sex: All·Age: 20 - 70

Code: NCT07621640

Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV

for Human Immunodeficiency Virus (HIV)

Sponsor: National Taiwan University Clinical Trial Center

Sex: All·Age: 18+

Code: NCT07707778·Phase 4

Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome

for Metabolic Syndrome

Sponsor: Seoul National University

Sex: All·Age: 40 - 65

Code: NCT07620886

Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)

for Spinal Cord Injury

3 sites incl. West Orange

Sponsor: Northwell Health

Sex: All·Age: 21 - 75

Code: NCT07625332·Phase 2, Phase 3

Apply to this trial

Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.

for Depressive Symptoms

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 15 - 20·Accepts healthy volunteers

Code: NCT07554326

Health Ahead Comparative Effectiveness Study

for Health Services Accessibility

1 site in Boulder

Sponsor: William Brandenburg, MD

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07669168

Apply to this trial

Efficacy of Physical Activity Program in Metabolic-syndrome Females With Behcet Disease

for Metabolic Syndrome

Sponsor: Cairo University

Sex: Female·Age: 40 - 50

Code: NCT07702123

Apply to this trial

Kodo Millet Porridge and Its Effects on Gut Health and Metabolic Syndrome

for Obesity & Overweight

Sponsor: JSS MEDICAL COLLEGE, JSS ACADEMY OF HIGHER EDUCATION AND RESEARCH

Sex: All·Age: 20 - 60

Code: NCT07703371

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Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic Health: A Cross-sectional Analysis.

for Atherosclerosis Cardiovascular Disease

Sponsor: Liverpool John Moores University

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT07474233

Exercise-Targeted Smart Lifestyle Management

for M-health

Sponsor: China National Center for Cardiovascular Diseases

Sex: All·Age: 20 - 60

Code: NCT07535333

CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry

for Psoriatic Arthritis

Sponsor: JULIO GRANADOS MONTIEL

Sex: All·Age: 18+

Code: NCT07567378

AI-Driven Metabolic Cohort in Overweight/Obese Chinese Adults

for Overweight and Obesity

Sponsor: Zhujiang Hospital

Sex: All·Age: 18 - 60

Code: NCT07584330

Emotional Eating, Sleep Quality, Mental State and Metabolic Syndrome

for Schizophrenia

Sponsor: Abant Izzet Baysal University

Sex: All·Age: 18 - 65

Code: NCT07411222

Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications

for Overweight and Obesity

Sponsor: University of Rijeka

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07431593

Apply to this trial

Human Observatory Study

for Aging

1 site in Boulder

Sponsor: Longevity Metrics, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07646782

Apply to this trial

Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment

for Metabolic Syndrome

Sponsor: Tarumanagara University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07491978

A Study Of Milk Consumption In Metabolic Syndrome

for Metabolic Syndrome

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT07401888

Apply to this trial

Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram

for Arterial Hypertension

Sponsor: I.M. Sechenov First Moscow State Medical University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07396792

Assess the Safety and Tolerability of SNS851 in Healthy Participants

for Metabolic Disease

Sponsor: Oneness Biotech Co., Ltd.

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07417124·Phase 1

Apply to this trial

Assessing the Association Between H. Pylori Persistence and the Severity of Insulin Resistance in Patients With Metabolic Syndrome

for Metabolic Syndrome

Sponsor: Center of New Medical Technologies

Sex: All·Age: 18 - 65

Code: NCT07501858

Apply to this trial

Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)

for Cardiovascular Risk Factors

Sponsor: Nemocnice AGEL Trinec-Podlesi a.s.

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07551960

Rutazyme Lemon Fermented Product Capsules for Metabolic Function in Adults With Obesity

for Obesity

Sponsor: National Taiwan Sport University

Sex: All·Age: 18 - 65

Code: NCT07540949

Apply to this trial

"Improving Health and Reducing Chronic Disease Risk in Middle-Aged Adults Through Nutrition"

for Metabolic Syndrome

Sponsor: IMDEA Food

Sex: All·Age: 30 - 50

Code: NCT06857929

Apply to this trial

iWAIST Trial: ERCG (Endoscopic Radial Compression Gastroplasty) vs Optimized Lifestyle Intervention for Weight Loss

for Overweight and/or Obesity

Sponsor: Liu Yan

Sex: All·Age: 18 - 65

Code: NCT07237750

Apply to this trial

Pharmacist-led Interventions in Psychiatric Patients

for Mental Disorders

Sponsor: University of Lahore

Sex: All·Age: 18 - 60

Code: NCT07446218

Personalized Transcranial Magnetic Stimulation (TMS) for Metabolic Dysfunction and Alcohol-Related Liver Disease

for Liver Diseases, Alcoholic

Sponsor: The Affiliated Hospital of Hangzhou Normal University

Sex: All·Age: 18 - 65

Code: NCT07399600

Study of the Effects of Food Formulations Containing Antioxidants, Prebiotic Fibers, and Oat Beta-glucans in Individuals at Risk of Metabolic Syndrome

for Metabolic Syndrome

Sponsor: Dr. Schär AG / SPA

Sex: All·Age: 18 - 60

Code: NCT07505277

Apply to this trial

Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure

for Resistant Hypertension

Sponsor: Mohamed Mohamed Ali Morgan

Sex: All·Age: 50 - 60

Code: NCT07383220

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ENDOCARE-SCREEN: Metabolic Liver Dysfunction Screening Study

for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH)

Sponsor: Jarosław Drobnik

Sex: All·Age: 18 - 75

Code: NCT07336563

Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects

for Prediabetic State

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18 - 75

Code: NCT07377097

Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly

for Chronic Kidney Disease

Sponsor: Chinese PLA General Hospital

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07357714

Effectiveness and Implementation of a Community-based Health Coach-led Artificial Intelligence (AI)-Powered Digital Self-Regulation Program for Individuals With Metabolic Syndrome (MetS)

for Metabolic Syndrome (MetS)

Sponsor: National University Health System, Singapore

Sex: All·Age: 21 - 65

Code: NCT07410325

Apply to this trial

Prevelance and Severity of Gerd in Patients With Metabolic Syndrome and How Both Affect Together ( Relationship)

for Metabolic Syndrome

Sponsor: Assiut University

Sex: All·Age: 18 - 65

Code: NCT07302022

MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

Sponsor: Linkoeping University

Sex: All·Age: 18+

Code: NCT07312136

Effects of Restricted-time and Psychochrononutritional Feeding in People With Metabolic Syndrome

for Metabolic Syndrome

Sponsor: University of Guadalajara

Sex: All·Age: 18 - 60

Code: NCT07389603

Apply to this trial

Exercise and Carotid Artery Function in Metabolic Syndrome

for Metabolic Syndrome

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07430839

Apply to this trial

HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking

for Metabolic Disease

Sponsor: Karolinska Institutet

Sex: All·Age: 35+

Code: NCT06952348

Apply to this trial

Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.

for Atherosclerosis Cardiovascular Disease

Sponsor: University of Seville

Sex: All·Age: 35 - 36·Accepts healthy volunteers

Code: NCT07361887

Apply to this trial

Metabolic Syndrome and Prediabetes

for Metabolic Syndrome

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18+

Code: NCT07243821

Apply to this trial

Velocity-Based Resistance Training in Kidney Transplant Recipients

for Kidney Transplant Recipients

Sponsor: Fundación Universitaria del Area Andina

Sex: All·Age: 18 - 50

Code: NCT07370727

Apply to this trial

Ambient Air and Noise Effect on Cardiovascular Health Risk and Lifestyle Intervention to Attenuate It (METSGREEN)

for Cardiovascular Diseases (CVD)

Sponsor: Regina Grazuleviciene

Sex: All·Age: 45 - 64

Code: NCT07111208

Apply to this trial

Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health

for Metabolic Syndrome

1 site in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18 - 75

Code: NCT07189234·Phase 2

Apply to this trial

Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: National Medical Research Center for Therapy and Preventive Medicine

Sex: All·Age: 50 - 74

Code: NCT07574333

Apply to this trial

Aerobic Exercise Addition to Cognitive Behavioural Treatment in Impotence Metabolic-syndrome Drinkers

for Heavy Drinking

Sponsor: Cairo University

Sex: Male·Age: 35 - 45

Code: NCT07277673

Apply to this trial

EFFECTS OF A YERBA MATE EXTRACT IN REDUCING METABOLIC SYNDROME IN OVERWEIGHT INDIVIDUALS

for Metabolic Syndrome

Sponsor: Universidade Federal da Fronteira Sul

Sex: All·Age: 40 - 65

Code: NCT07000825

Truway Diagnostic Tools in Primary Care

for Chronic Disease

1 site in New York

Sponsor: Truway Health, Inc.

Sex: All·Age: All ages

Code: NCT07209527·EARLY_Phase 1

Metabolic syndrome clinical trials — common questions

Are metabolic syndrome clinical trials free to join?

Yes. Participating in a metabolic syndrome clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a metabolic syndrome clinical trial?

Each metabolic syndrome study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a metabolic syndrome trial near me?

Use the location controls above. We'll show recruiting metabolic syndrome trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many metabolic syndrome trials are recruiting right now?

We're currently tracking roughly 71 recruiting metabolic syndrome trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Metabolic syndrome trials by city

Boston, MA Ann Arbor, MI Aurora, CO Boulder, CO Chicago, IL Birmingham, AL Cleveland, OH Fort Collins, CO Indianapolis, IN Madison, WI Detroit, MI

Related specialties

Endocrinology Metabolic health Weight loss