FlexED: National Substudy
for Eating Disorders
1 location in Durham
Sponsor: Duke University
Sex: All·Age: 18 - 25
Code: NCT07807774·Recruiting·Listed Sep 8, 2026
Clinical Trials at Duke University Medical Center
As of September 2026, 252 paid clinical trials are recruiting at Duke University Medical Center, located at ERWIN RD, DURHAM, NC 27710-0001, phone (919) 684-2711 in Durham, North Carolina. Active studies at this site cover conditions such as Breast Cancer, Heart Failure and Prostate Cancer. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Durham
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy
for Symptomatic Genetic Dilated Cardiomyopathy (DCM)
Sites in Durham +27 more locations
Sponsor: Kardigan, Inc.
Sex: All·Age: 18+
Code: NCT07771465·Phase 3·Recruiting·Listed Aug 18, 2026
254 clinical trials at Duke University Medical Center
·Clear filters· Get a weekly email when new trials open in Durham, NC.
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
for Urothelial Cancer
Drug: PF-08634404
Sites in Durham, Cary +131 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07421700·Phase 1, Phase 2·Recruiting·Listed Feb 2026
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
for Proteinuric Kidney Diseases
Sites in Durham +25 more locations
Sponsor: Boehringer Ingelheim
Sex: All·Age: 12+
Code: NCT07355296·Phase 2·Recruiting·Listed Jan 2026
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
for Adenovirus Infections
Sites in Durham +31 more locations
Sponsor: SymBio Pharmaceuticals
Sex: All·Age: 2 Months+
Code: NCT07387367·Phase 3·Recruiting·Listed Feb 2026
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
for Metabolic Dysfunction Associated Steatohepatitis (MASH)
Drug: Survodutide
Sites in Durham, Raleigh +161 more locations
Sponsor: Boehringer Ingelheim
Sex: All·Age: 18+
Code: NCT06632444·Phase 3·Recruiting·Listed Oct 2024
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
for Focal Segmental Glomerulosclerosis
Sites in Durham, Greensboro +69 more locations
Sponsor: Boehringer Ingelheim
Sex: All·Age: 12+
Code: NCT07220083·Phase 3·Recruiting·Listed Oct 2025
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
for Crohn's Disease
Drug: Duvakitug
Sites in Durham, Chapel Hill +123 more locations
Sponsor: Sanofi
Sex: All·Age: 16 - 80
Code: NCT07184931·Phase 3·Recruiting·Listed Sep 2025
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
for Ulcerative Colitis
Drug: Duvakitug
Sites in Durham, Chapel Hill +116 more locations
Sponsor: Sanofi
Sex: All·Age: 16 - 80
Code: NCT07184996·Phase 3·Recruiting·Listed Sep 2025
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
for Advanced Non-Small Cell Lung Cancer
Drug: Adagrasib
Sites in Durham +191 more locations
Sponsor: Mirati Therapeutics Inc.
Sex: All·Age: 18+
Code: NCT04613596·Phase 2, Phase 3·Recruiting·Listed Nov 2020
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
for Neoplasms
Sites in Durham, Chapel Hill +75 more locations
Sponsor: Celgene
Sex: All·Age: All ages
Code: NCT03435796·Phase 2, Phase 3·Recruiting·Listed Feb 2018
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
for Chronic Lymphocytic Leukemia
Sites in Durham, Chapel Hill +45 more locations
Sponsor: BeOne Medicines
Sex: All·Age: 18+
Code: NCT06973187·Phase 3·Recruiting·Listed May 2025
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
for Colorectal Neoplasms
Sites in Durham, Pinehurst +106 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT05253651·Phase 3·Recruiting·Listed Feb 2022
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
for Parkinson's Disease
Drug: Prasinezumab
Sites in Durham, Asheville +51 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 50 - 85
Code: NCT07174310·Phase 3·Recruiting·Listed Sep 2025
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
for Peripheral Vascular Diseases
Sites in Durham, Raleigh +36 more locations
Sponsor: Boston Scientific Corporation
Sex: All·Age: 18+
Code: NCT04674969·Recruiting·Listed Dec 2020
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
for Pancreatic Neuroendocrine Tumor (pNET)
Sites in Durham, Chapel Hill +38 more locations
Sponsor: Exelixis
Sex: All·Age: 18+
Code: NCT06943755·Phase 2, Phase 3·Recruiting·Listed Apr 2025
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML
for Acute Myeloid Leukemia (AML)
Sites in Durham, Chapel Hill +40 more locations
Sponsor: Kura Oncology, Inc.
Sex: All·Age: 18+
Code: NCT07007312·Phase 3·Recruiting·Listed Jun 2025
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
for Pancreatic Ductal Adenocarcinoma
Sites in Durham +24 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT06586515·Phase 1·Recruiting·Listed Sep 2024
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
for Colorectal Cancer
Sites in Durham +31 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT06445062·Phase 1, Phase 2·Recruiting·Listed Jun 2024
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
for Prostate Cancer
Sites in Durham +20 more locations
Sponsor: Amgen
Sex: Male·Age: 18+
Code: NCT04221542·Phase 1·Recruiting·Listed Jan 2020
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
for Sickle Cell Disease
Drug: Etavopivat
Sites in Durham, Winston-Salem +42 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 12+
Code: NCT06612268·Phase 3·Recruiting·Listed Sep 2024
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
for Amyloidosis
Drug: Acoramidis
Sites in Durham +39 more locations
Sponsor: Eidos Therapeutics, a BridgeBio company
Sex: All·Age: 18 - 75
Code: NCT06563895·Phase 3·Recruiting·Listed Aug 2024
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
for Heart Failure - NYHA II - IV
Sites in Durham, Charlotte +38 more locations
Sponsor: Boston Scientific Corporation
Sex: All·Age: 18+
Code: NCT07069738·Recruiting·Listed Jul 2025
ELEVATE-HFpEF Clinical Study
for Heart Failure With Preserved Ejection Fraction (HFpEF)
Sites in Durham +25 more locations
Sponsor: Medtronic Cardiac Rhythm and Heart Failure
Sex: All·Age: 40+
Code: NCT06678841·Recruiting·Listed Nov 2024
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
for Progressive Pulmonary Fibrosis
Sites in Durham, Greensboro +72 more locations
Sponsor: United Therapeutics
Sex: All·Age: 18+
Code: NCT05943535·Phase 3·Recruiting·Listed Jul 2023
Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy
for Cancer Weight Loss
Sites in Durham +24 more locations
Sponsor: Endevica Bio
Sex: All·Age: 18+
Code: NCT06937177·Phase 2·Recruiting·Listed Apr 2025
Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
for Metastatic Breast Cancer
Sites in Durham +30 more locations
Sponsor: LeonaBio
Sex: All·Age: 18+
Code: NCT05696626·Phase 3·Recruiting·Listed Jan 2023
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
for Complex Congenital Heart Defect
Sites in Durham +20 more locations
Sponsor: Edwards Lifesciences
Sex: All·Age: All ages
Code: NCT02744677·Recruiting·Listed Apr 2016
Nectero EAST System Clinical Study
for Abdominal Aortic Aneurysm
Sites in Durham +32 more locations
Sponsor: Nectero Medical, Inc.
Sex: All·Age: 21 - 85
Code: NCT06001918·Phase 2, Phase 3·Recruiting·Listed Aug 2023
A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)
for Graft-versus-host Disease (GVHD)
Drug: Ruxolitinib
Sites in Durham, Chapel Hill +28 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 18+
Code: NCT06615050·Phase 3·Recruiting·Listed Sep 2024
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Sites in Durham +36 more locations
Sponsor: Intellia Therapeutics
Sex: All·Age: 18 - 90
Code: NCT06128629·Phase 3·Recruiting·Listed Nov 2023
A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma
for Plasma Cell Myeloma Refractory
Sites in Durham +33 more locations
Sponsor: Sanofi
Sex: All·Age: 18+
Code: NCT06356571·Phase 2·Recruiting·Listed Apr 2024
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
for Metastatic Uveal Melanoma
Drug: Nivolumab
Sites in Durham +28 more locations
Sponsor: Replimune, Inc.
Sex: All·Age: All ages
Code: NCT06581406·Phase 2, Phase 3·Recruiting·Listed Sep 2024
A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
for Gastrointestinal Stromal Tumor (GIST)
Sites in Durham +31 more locations
Sponsor: Kura Oncology, Inc.
Sex: All·Age: 18+
Code: NCT06655246·Phase 1·Recruiting·Listed Oct 2024
Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis
for AAA - Abdominal Aortic Aneurysm
Sites in Durham, Chapel Hill +54 more locations
Sponsor: W.L.Gore & Associates
Sex: All·Age: 18+
Code: NCT06218875·Recruiting·Listed Jan 2024
Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy
for Prostate Cancer
Sites in Durham +28 more locations
Sponsor: Clarity Pharmaceuticals Ltd
Sex: Male·Age: 18+
Code: NCT06056830·Phase 3·Recruiting·Listed Sep 2023
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
for Myelofibrosis
Drug: Ruxolitinib
Sites in Durham, Wilson +56 more locations
Sponsor: Kartos Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06479135·Phase 3·Recruiting·Listed Jun 2024
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
for Single Ventricle Heart Disease
Sites in Durham, Charlotte +35 more locations
Sponsor: Mezzion Pharma Co. Ltd
Sex: All·Age: 12 - 18
Code: NCT05918211·Phase 3·Recruiting·Listed Jun 2023
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
for Pancreatic Cancer
Drug: daraxonrasib
Sites in Durham +17 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT07491445·Phase 3·Recruiting·Listed Mar 2026
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
for Ovarian Neoplasms
Sites in Durham +18 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07213791·Phase 1·Recruiting·Listed Oct 2025
A Gaucher Disease Gene Therapy Trial With FLT201
for Gaucher Disease Type 1
Sites in Durham +15 more locations
Sponsor: Spur Therapeutics
Sex: All·Age: 18+
Code: NCT07223944·Phase 3·Recruiting·Listed Nov 2025
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
for Non-Small Cell Lung Cancer (NSCLC)
Drug: Sotorasib
Sites in Durham, Pinehurst +21 more locations
Sponsor: Amgen
Sex: All·Age: 18 - 100
Code: NCT05920356·Phase 3·Recruiting·Listed Jun 2023
Common conditions studied in Durham
- Breast Cancer (20 active studies)
- Heart Failure (20 active studies)
- Prostate Cancer (16 active studies)
- Cancer (12 active studies)
- Acute Myeloid Leukemia (11 active studies)
- Colorectal Cancer (11 active studies)
Leading research sponsors in Durham
- Duke University
- VA Office of Research and Development
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Durham?
There are approximately 1,059 recruiting clinical trials in Durham, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Durham pay participants?
Most recruiting trials in Durham compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Durham?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Durham?
The most common conditions under active study in Durham include Breast Cancer (20), Heart Failure (20), Prostate Cancer (16), Cancer (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Durham?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Durham on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Durham?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Durham?
Recruiting research sites in Durham include Duke University Medical Center, Duke University, Duke University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Durham right now?
The largest active categories in Durham are Cancer & tumors (292), Cardiovascular (97), Neurology & pain (68). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Duke University Medical Center?
Duke University Medical Center is located at ERWIN RD, DURHAM, NC 27710-0001. Use the Google Maps link in the intro above to get directions.
How do I contact Duke University Medical Center?
You can reach Duke University Medical Center by phone at (919) 684-2711. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
Browse more clinical trials
Other cities in North Carolina
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