Paid Clinical Trials in Matthews, NC
As of July 2026, 25 paid clinical trials are recruiting in Matthews, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Matthews offers studies at sites including Levine Cancer Institute - Union West for conditions such as Alzheimer's Disease, Alzheimer Disease, Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Matthews
Trials by drug in Matthews
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Newly added in Matthews
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
24 clinical trials
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
E-Mindfulness Approaches for Living After Breast Cancer
The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Unity VCS: A Comparison Study Evaluating Corneal Clarity and Thickness
Open-label Extension Study in Participants With Early Alzheimer's Disease
Top Research Study Locations in Matthews
Researchers run research studies in Matthews, NC at 13 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Levine Cancer Institute - Union West | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 9 |
| Novant Health Cancer Institute - Matthews | Anatomic Stage II Breast Cancer AJCC v8, Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Anaplastic Large Cell Lymphoma, ALK-Negative | 8 |
| Matthews Radiation Oncology Center | Anaplastic Large Cell Lymphoma, ALK-Negative, Breast Cancer, Follicular Helper T-Cell Lymphoma | 6 |
| AMC Research, LLC - Flourish - PPDS | Alzheimer Disease, Psychosis Associated With Alzheimer's Disease | 2 |
| AMC Research, LLC | Alzheimer's Disease, Early Alzheimer's Disease | 2 |
| Alzheimer's Memory Center - AMC Research | AD, Alzheimer Disease, Cognitive Impairment | 1 |
| Atrium Health Levine Children's Charlotte Pediatrics | Pneumococcal Disease | 1 |
| Atrium Health STRIVE Research Clinic - Matthews | Pneumococcal Disease | 1 |
| Flourish Research | Alzheimer's Disease, Amyloid Plaque, Beta-Amyloid | 1 |
| GSK Investigational Site | Alzheimer's Disease | 1 |
| Levine Cancer Institute | Metastatic Breast Cancer | 1 |
| Metrolina Eye Associates | Cataract | 1 |
| Novant Health Matthews Med Ctr | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Matthews (2026)
Recruiting trials in Matthews grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (14 active studies)
- Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer · Phase 3 · National Cancer Institute (NCI)
- ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab · Phase 3 · Alliance for Clinical Trials in Oncology
Neurology & pain (2 active studies)
- A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4) · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015) · Cognito Therapeutics, Inc.
Mental health & behavior (1 active study)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Eye & vision (1 active study)
- Unity VCS: A Comparison Study Evaluating Corneal Clarity and Thickness · Metrolina Eye Associates, PLLC
Common conditions studied in Matthews
- Alzheimer's Disease (3 active studies)
- Alzheimer Disease (2 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (2 active studies)
- Breast Cancer (2 active studies)
- AD (1 active study)
- Advanced Lung Non-Squamous Non-Small Cell Carcinoma (1 active study)
Leading research sponsors in Matthews
- NRG Oncology
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- AC Immune SA
Frequently asked questions
How many paid clinical trials are currently recruiting in Matthews?
There are approximately 25 recruiting clinical trials in Matthews, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Matthews pay participants?
Most recruiting trials in Matthews compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Matthews?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Matthews?
The most common conditions under active study in Matthews include Alzheimer's Disease (3), Alzheimer Disease (2), Anatomic Stage II Breast Cancer AJCC v8 (2), Breast Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Matthews?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Matthews on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Matthews?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Matthews?
Recruiting research sites in Matthews include Levine Cancer Institute - Union West, Novant Health Cancer Institute - Matthews, Matthews Radiation Oncology Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Matthews right now?
The largest active categories in Matthews are Cancer & tumors (14), Neurology & pain (2), Mental health & behavior (1). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.