Paid Clinical Trials in Greenville, NC
As of September 2026, 156 paid clinical trials are recruiting in Greenville, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Greenville offers studies at sites including East Carolina University for conditions such as Acute Myeloid Leukemia, Sickle Cell Disease, Heart Failure, Hypertension. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Greenville
Trials by drug in Greenville
Filter results
Newly added in Greenville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
144 clinical trials
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
ATLAS (AltaValve) Pivotal Trial
Top Research Study Locations in Greenville
Researchers run research studies in Greenville, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| East Carolina University | Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, B Acute Lymphoblastic Leukemia | 83 |
| Brody School of Medicine at East Carolina University | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC), Factor VII Deficiency | 7 |
| ECU Health Medical Center | Atrial Fibrillation, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC) | 6 |
| East Carolina University Health Medical Center | Aneurysm, Intracranial, Brain Aneurysm, Fusiform Aneurysm | 3 |
| North Carolina Retina Associates | Age - Related Macular Degeneration (AMD), Age-Related Macular Degeneration, Branch Retinal Vein Occlusion (BRVO) | 3 |
| Greenville, NC Investigative | Acute Heart Failure, Heart Failure | 3 |
| Carolina Researche | Liver Fibrosis, Metabolic Dysfunction Associated Steatohepatitis, Metabolic Dysfunction Associated Steatohepatitis (MASH) | 2 |
| Physicians East Endocrinology | Adult Growth Hormone Deficiency, Heart Failure, Obesity | 2 |
| Physicians East, PA | Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension | 2 |
| AURORA-1 Clinical Site | Chronic Weight Management, Obesity, Overweight | 1 |
| AURORA-2 Clinical Site | Chronic Weight Management, Obesity, Overweight | 1 |
| Ascendis Pharma Investigational Site | Endocrine System Diseases, Hypoparathyroidism, Parathyroid Diseases | 1 |
| Ascentage Investigative Site | CLL/SLL | 1 |
| Ascentage Investigative | CML, CML, Chronic Phase, Chronic Myeloid Leukemia | 1 |
| Bausch Health | Ulcerative Colitis | 1 |
| Calcilytix Therapeutics, Inc., a BridgeBio Company, Investigational Site | Chronic Hypoparathyroidism, Hypoparathyroidism | 1 |
| Carolina Breast Imaging Specialists | Breast Cancer | 1 |
| Carolina Digestive Diseases | Crohn's Disease, Ulcerative Colitis | 1 |
| Carolina Digestive Diseases and Endoscopy Center | Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe | 1 |
| Clinical Trial Site | High Cardiovascular Risk, High Risk Cardiovascular Disease, Hypertension | 1 |
| ECU Brody School of Medicine | Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC) | 1 |
| ECU Family Medicine Center | Hypertension | 1 |
| ECU Physicians Nephrology and Hypertension | Primary Membranous Nephropathy | 1 |
| ECU Physicians, Brody Outpatient Clinic | Sickle Cell Disease | 1 |
| East Carolina (University of North Carolina) | Sickle Cell Disease | 1 |
Active & Upcoming Studies in Greenville (2026)
Recruiting trials in Greenville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (53 active studies)
- Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma · Phase 2, Phase 3 · TuHURA Biosciences, Inc.
- Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression · Phase 3 · Incyte Corporation
Cardiovascular (17 active studies)
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
Diabetes & metabolic (7 active studies)
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities · Phase 3 · Ascletis Pharma (China) Co., Limited
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
Pediatric (5 active studies)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
- Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit · East Carolina University
Neurology & pain (3 active studies)
Eye & vision (3 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD · Phase 2 · ONL Therapeutics
Mental health & behavior (2 active studies)
- Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use · Phase 4 · West Virginia University
- Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit · East Carolina University
Vaccines (1 active study)
- You and Me Healthy · Duke University
Common conditions studied in Greenville
- Acute Myeloid Leukemia (9 active studies)
- Sickle Cell Disease (8 active studies)
- Heart Failure (4 active studies)
- Hypertension (4 active studies)
- Acute Myeloid Leukemia Post Cytotoxic Therapy (3 active studies)
- Atrial Fibrillation (3 active studies)
Leading research sponsors in Greenville
- National Cancer Institute (NCI)
- Children's Oncology Group
- East Carolina University
- Alliance for Clinical Trials in Oncology
- Pfizer
Frequently asked questions
How many paid clinical trials are currently recruiting in Greenville?
There are approximately 156 recruiting clinical trials in Greenville, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Greenville pay participants?
Most recruiting trials in Greenville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Greenville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Greenville?
The most common conditions under active study in Greenville include Acute Myeloid Leukemia (9), Sickle Cell Disease (8), Heart Failure (4), Hypertension (4), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Greenville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Greenville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Greenville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Greenville?
Recruiting research sites in Greenville include East Carolina University, Brody School of Medicine at East Carolina University, ECU Health Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Greenville right now?
The largest active categories in Greenville are Cancer & tumors (53), Cardiovascular (17), Diabetes & metabolic (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.