Paid Clinical Trials in Cary, NC
As of July 2026, 66 paid clinical trials are recruiting in Cary, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Cary offers studies at sites including Duke Cancer Center Cary for conditions such as Anatomic Stage II Breast Cancer AJCC v8, Obesity, Obesity and Overweight, Breast Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Cary
Trials by drug in Cary
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63 clinical trials
↓ Download CSVA 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK
A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
The THOR IDE Study
Shield Post-Approval Study Protocol
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
MiSight 1 Day Safety Post-Approval Study
A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL
MagDI U.S. Registry
Drug-Drug Interaction Study of ABP-671 in Gout Patients
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
About research studies in Cary
Cary has approximately 66 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.
Top Research Study Locations in Cary
Researchers run research studies in Cary, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Duke Cancer Center Cary | Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer, Advanced Extrapulmonary Neuroendocrine Carcinoma | 17 |
| UNC Health Cancer Care Cary | Anatomic Stage II Breast Cancer AJCC v8, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | 7 |
| True You Weight Loss | Obesity, Obesity Prevention, Obesity Recidivism | 4 |
| Accellacare - Cary | Clostridioides Difficile Associated Disease, Plaque Psoriasis | 2 |
| North Carolina Retina Associates | Geographic Atrophy, Macular Degeneration, Neovascular Age-Related Macular Degeneration (nAMD) | 2 |
| North Carolina Retina Associates (Cary) | Macular Edema Secondary to Inflammation | 2 |
| Vascular Solutions of North Carolina | Chronic Pain, Osteoarthritis Shoulder, Osteoarthritis Thumb | 2 |
| Waverly Hematology Oncology | Breast Cancer, Stage III Colon Cancer | 2 |
| Magnolia Clinical Research, LLC | Depressive Disorder, Treatment-Resistant, Major Depressive Disorder (MDD), Major Depressive Disorder | 2 |
| WakeMed Cancer Care - Waverly Hematology & Medical Oncology | Breast Neoplasms, Neoplasm Metastasis, Hematologic Malignancies | 2 |
| Shady Grove Fertility | Chaotic Aneuploidy, Complex Aneuploidy | 1 |
| Accellacare of Cary | Chronic Idiopathic Constipation (CIC) | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
| Bariatric Specialists of the Carolinas | Anastomosis, Surgical, Bowel Obstruction, Internal Hernia | 1 |
| Cary Cardiology | Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension | 1 |
| Cary Family Eye Care | Myopia | 1 |
| Cary Gastroenterology Associates | Colo-rectal Cancer | 1 |
| Cary, North Carolina | Branch Retinal Vein Occlusion (BRVO), Neovascular Age-Related Macular Degeneration (NVAMD) | 1 |
| Duke Cancer Institute Cary | Metastatic Cancer, Oligometastasis | 1 |
| Forum Health Cary | Obesity and Overweight | 1 |
| Forum Health_Cary (Civia) | Diabetes, Type 2, Obesity, Overweight | 1 |
| Local Institution - 0042 | Schizophrenia | 1 |
| NC Retina | Age-Related Macular Degeneration, Choroidal Neovascularization, Macular Degeneration | 1 |
| NC Retina Associates | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA) | 1 |
| North Carolina Nephrology P.A. - Cary | Proteinuric Kidney Disease | 1 |
Active & Upcoming Studies in Cary (2026)
Recruiting trials in Cary grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (22 active studies)
- Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer · Phase 2 · National Cancer Institute (NCI)
- This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve. · Phase 3 · Pfizer
Diabetes & metabolic (9 active studies)
- A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin · Phase 3 · AstraZeneca
- A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D) · Phase 3 · Pfizer
Eye & vision (7 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO · Phase 2 · EyeBiotech Ltd.
Mental health & behavior (3 active studies)
- Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT) · Bristol-Myers Squibb
- A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder · Phase 2 · VistaGen Therapeutics, Inc.
Cardiovascular (3 active studies)
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
- Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction · Phase 3 · Cytokinetics
Neurology & pain (1 active study)
- Embo Registry; National Registry for Artery Embolization · Vascular Solutions of North Carolina
Pediatric (1 active study)
- Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement · University of North Carolina, Chapel Hill
Common conditions studied in Cary
- Anatomic Stage II Breast Cancer AJCC v8 (3 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Obesity (3 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Obesity and Overweight (3 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Breast Cancer (2 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Macular Degeneration (2 active studies). Recruiting Macular Degeneration studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Macular Edema Secondary to Inflammation (2 active studies). Recruiting Macular Edema Secondary to Inflammation studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Cary
- Alliance for Clinical Trials in Oncology
- NRG Oncology
- National Cancer Institute (NCI)
- Pfizer
- AstraZeneca
Local regulations and guidelines
Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Cary. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Cary
Hipa.ai aggregates every recruiting study in Cary from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Cary?
There are approximately 66 recruiting clinical trials in Cary, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Cary pay participants?
Most recruiting trials in Cary compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Cary?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Cary?
The most common conditions under active study in Cary include Anatomic Stage II Breast Cancer AJCC v8 (3), Obesity (3), Obesity and Overweight (3), Breast Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Cary?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Cary on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Cary?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Cary?
Recruiting research sites in Cary include Duke Cancer Center Cary, UNC Health Cancer Care Cary, True You Weight Loss, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Cary right now?
The largest active categories in Cary are Cancer & tumors (22), Diabetes & metabolic (9), Eye & vision (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.