Paid Clinical Trials in Cary, NC
As of September 2026, 63 paid clinical trials are recruiting in Cary, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Cary offers studies at sites including Duke Cancer Center Cary for conditions such as Anatomic Stage II Breast Cancer AJCC v8, Alopecia Areata, Anatomic Stage IIIA Breast Cancer AJCC v8, Geographic Atrophy (GA). Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Cary
Trials by drug in Cary
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Newly added in Cary
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
62 clinical trials
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
Shield Post-Approval Study Protocol
A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE
A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK
The THOR IDE Study
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL
MagDI U.S. Registry
Drug-Drug Interaction Study of ABP-671 in Gout Patients
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
Top Research Study Locations in Cary
Researchers run research studies in Cary, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Duke Cancer Center Cary | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Advanced Hepatocellular Carcinoma | 19 |
| True You Weight Loss | Obesity, Obesity Prevention, Obesity Recidivism | 4 |
| UNC Health Cancer Care Cary | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Cancer | 3 |
| Waverly Hematology Oncology | Breast Cancer, Clear Cell Renal Cell Carcinoma, Renal Cell Carcinoma (RCC) | 3 |
| Magnolia Clinical Research, LLC | Depressive Disorder, Treatment-Resistant, Major Depressive Disorder (MDD), Schizophrenia | 3 |
| Accellacare - Cary | Clostridoides Difficile Associated Disease, Plaque Psoriasis | 2 |
| North Carolina Retina Associates | Age - Related Macular Degeneration (AMD), Geographic Atrophy (GA), Neovascular Age-Related Macular Degeneration (nAMD) | 2 |
| North Carolina Retina Associates (Cary) | Macular Edema Secondary to Inflammation | 2 |
| Vascular Solutions of North Carolina | Chronic Pain, Osteoarthritis Shoulder, Osteoarthritis Thumb | 2 |
| WakeMed Cancer Care - Waverly Hematology & Medical Oncology | Breast Neoplasms, Neoplasm Metastasis, Hematologic Malignancies | 2 |
| Shady Grove Fertility | Chaotic Aneuploidy, Complex Aneuploidy | 1 |
| Accellacare - Cary (Cary Medical Group) | Migraine | 1 |
| Accellacare of Cary | Chronic Idiopathic Constipation (CIC) | 1 |
| Adverum Clinical | Neovascular Age-Related Macular Degeneration (nAMD), Wet AMD | 1 |
| Bariatric Specialists of the Carolinas | Anastomosis, Surgical, Bowel Obstruction, Internal Hernia | 1 |
| Cary Cardiology | Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension | 1 |
| Cary Gastroenterology Associates | Colo-rectal Cancer | 1 |
| Cary, North Carolina | Branch Retinal Vein Occlusion (BRVO), Neovascular Age-Related Macular Degeneration (NVAMD) | 1 |
| Duke Cancer Institute Cary | Metastatic Cancer, Oligometastasis | 1 |
| Magnolia Clinical Research | Major Depressive Disorder | 1 |
| Magnolia Clinical Research LLC | Depressive Disorder, Major | 1 |
| NC Retina | Age-Related Macular Degeneration, Choroidal Neovascularization, Macular Degeneration | 1 |
| NC Retina Associates | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA) | 1 |
| North Carolina Nephrology P.A. - Cary | Proteinuric Kidney Disease | 1 |
| Ortho Surg Ctr Panther Creek | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Cary (2026)
Recruiting trials in Cary grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (20 active studies)
- Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial · Phase 3 · National Cancer Institute (NCI)
- Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer · Phase 1, Phase 2 · Pfizer
Eye & vision (8 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
Diabetes & metabolic (7 active studies)
- A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin · Phase 3 · AstraZeneca
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
Mental health & behavior (2 active studies)
- Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT) · Bristol-Myers Squibb
- A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder · Phase 2 · VistaGen Therapeutics, Inc.
Neurology & pain (2 active studies)
- A Study to Assess the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- Embo Registry; National Registry for Artery Embolization · Vascular Solutions of North Carolina
Cardiovascular (2 active studies)
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
- Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction · Phase 3 · Cytokinetics
Pediatric (1 active study)
- Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement · University of North Carolina, Chapel Hill
Common conditions studied in Cary
- Anatomic Stage II Breast Cancer AJCC v8 (4 active studies)
- Alopecia Areata (2 active studies)
- Anatomic Stage IIIA Breast Cancer AJCC v8 (2 active studies)
- Geographic Atrophy (GA) (2 active studies)
- HER2-Negative Breast Carcinoma (2 active studies)
- Macular Edema Secondary to Inflammation (2 active studies)
Leading research sponsors in Cary
- National Cancer Institute (NCI)
- NRG Oncology
- Pfizer
- Alliance for Clinical Trials in Oncology
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Cary?
There are approximately 63 recruiting clinical trials in Cary, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Cary pay participants?
Most recruiting trials in Cary compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Cary?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Cary?
The most common conditions under active study in Cary include Anatomic Stage II Breast Cancer AJCC v8 (4), Alopecia Areata (2), Anatomic Stage IIIA Breast Cancer AJCC v8 (2), Geographic Atrophy (GA) (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Cary?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Cary on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Cary?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Cary?
Recruiting research sites in Cary include Duke Cancer Center Cary, True You Weight Loss, UNC Health Cancer Care Cary, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Cary right now?
The largest active categories in Cary are Cancer & tumors (20), Eye & vision (8), Diabetes & metabolic (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.