Paid Clinical Trials in Irvine, CA
As of July 2026, 358 paid clinical trials are recruiting in Irvine, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Irvine offers studies at sites including City of Hope at Irvine Lennar for conditions such as Breast Cancer, Endometrial Cancer, Multiple Myeloma, Anatomic Stage IV Breast Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Irvine
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Researchers run research studies in Irvine, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| City of Hope at Irvine Lennar | Stage IV Lung Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | 56 |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Metastatic Malignant Solid Neoplasm, Stage IV Colorectal Cancer AJCC v8, Stage III Laryngeal Cancer AJCC v8 | 56 |
| University of California, Irvine | Alopecia Areata, Alzheimer Disease, Amyotrophic Lateral Sclerosis | 35 |
| Kaiser Permanente-Irvine | Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer, Ovarian Carcinoma | 19 |
| University of California Irvine | Acute Decompensated Heart Failure, Age-related Macular Degeneration (AMD), Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV) | 19 |
| City of Hope Orange County Lennar Foundation Cancer Center | Multiple Myeloma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 10 |
| City of Hope - Orange County Lennar Foundation Cancer Center | Breast Cancer, Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer, Non Small Cell Lung Cancer | 10 |
| City of Hope | Advanced Hodgkin Lymphoma, Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma | 8 |
| Irvine Clinical Research | Alzheimer Disease, Major Depressive Disorder, Alzheimer's Disease | 7 |
| Chao Family Comprehensive Cancer Center and Ambulatory Care | Endometrial Cancer, Breast Cancer, Cachexia | 5 |
| Beckman Laser Institute and Medical Clinic | Abnormal Vascular Flow, Dermatologic Diseases, Gingivitis | 4 |
| Hoag Memorial Hospital Presbyterian | Prostate Cancer, B7H3, Castration Resistant Metastatic Prostate Cancer | 4 |
| City of Hope - Lennar | Anemia, KRAS G12C-mutated Solid Tumors, Lung Cancer, KRAS, NRAS, HRAS-mutated NSCLC | 3 |
| Hoag Hospital Irvine | Breast Cancer, Breast Cancer Metastatic, Breast Neoplasm | 3 |
| Hoag Memorial Hospital | Esophageal Cancer, Gastric Cancer (GC), Gastroesophageal Junction | 3 |
| Irvine Center for Clinical Research | Alzheimers Disease, Alzheimer's Disease | 3 |
| Susan Samueli Integrative Health Institute | Fibromyalgia, Hypertension, Mild to Moderate Hypertension | 3 |
| UC Irvine | Advanced Adenocarcinoma, Diabetes Mellitus Type 2, Neutropenia | 3 |
| Univ of California, Irvine- Gavin Herbert Eye Institute | Amblyopia | 3 |
| University of California - Irvine Medical Center | Huntington's Disease, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ, Pompe Disease | 3 |
| University of California at Irvine | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 3 |
| City of Hope at Orange County Lennar Foundation Cancer Center | Gastric Adenocarcinoma, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma | 3 |
| City of Hope Lennar Foundation Cancer Center | Carcinoma, Small Cell Lung, Lung Neoplasms, Small Cell Cancer Of The Lung | 3 |
| ATP Clinical Research Inc. | Lewy Body Dementia Psychosis | 2 |
| Axiom Research, Orange County | Acute Migraine, Migraine | 2 |
Active & Upcoming Studies in Irvine (2026)
Recruiting trials in Irvine grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (180 active studies)
- Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery · Phase 2 · City of Hope Medical Center
- Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3 · Phase 2 · City of Hope Medical Center
Neurology & pain (23 active studies)
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY) · Phase 3 · Alexandre P. Joosten
Diabetes & metabolic (6 active studies)
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
- Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass · Boston Scientific Corporation
Cardiovascular (6 active studies)
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
- Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) · Phase 3 · Reprieve Cardiovascular, Inc
Mental health & behavior (4 active studies)
- Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) · University of California, Irvine
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Eye & vision (3 active studies)
- Development and Evaluation of Functional Visual Field and Navigation Endpoints in Moderate to Profound Inherited Retinal Disease (DEFINE-IRD) · Ray Therapeutics, Inc.
- A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy · Phase 3 · Regeneron Pharmaceuticals
Vaccines (2 active studies)
- Exercise in Child Health · University of California, Irvine
- SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry · Massive Bio, Inc.
Common conditions studied in Irvine
- Breast Cancer (10 active studies)
- Endometrial Cancer (8 active studies)
- Multiple Myeloma (8 active studies)
- Anatomic Stage IV Breast Cancer AJCC v8 (7 active studies)
- Metastatic Malignant Solid Neoplasm (6 active studies)
- Stage IV Lung Cancer AJCC v8 (6 active studies)
Leading research sponsors in Irvine
- National Cancer Institute (NCI)
- University of California, Irvine
- City of Hope Medical Center
- NRG Oncology
- AbbVie
Frequently asked questions
How many paid clinical trials are currently recruiting in Irvine?
There are approximately 358 recruiting clinical trials in Irvine, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Irvine pay participants?
Most recruiting trials in Irvine compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Irvine?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Irvine?
The most common conditions under active study in Irvine include Breast Cancer (10), Endometrial Cancer (8), Multiple Myeloma (8), Anatomic Stage IV Breast Cancer AJCC v8 (7), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Irvine?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Irvine on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Irvine?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Irvine?
Recruiting research sites in Irvine include City of Hope at Irvine Lennar, UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, University of California, Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Irvine right now?
The largest active categories in Irvine are Cancer & tumors (180), Neurology & pain (23), Diabetes & metabolic (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.