Lung oncology Clinical Trials in Philadelphia, PA
As of August 2026, 46 paid clinical trials are recruiting for Lung oncology in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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46 clinical trials for Lung oncology
·Clear filters·Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung
A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
TCR1188-ABC Cells in KRAS-mutated Cancers
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer
A Registry for People With Lung Cancer
Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance
Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES
Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking
Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer
Top Research Study Locations in Philadelphia
Researchers run research studies in Philadelphia, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pennsylvania | Heart Failure, Opioid Use Disorder, Colorectal Cancer | 358 |
| Children's Hospital of Philadelphia | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, Pediatric Cancer | 307 |
| Thomas Jefferson University Hospital | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 110 |
| Fox Chase Cancer Center | Breast Cancer, Cancer, Urothelial Carcinoma | 96 |
| Thomas Jefferson University | Focal Epilepsy, Advanced Melanoma, Cancer | 96 |
| Hospital of the University of Pennsylvania | Abdominal Aortic Aneurysm, Breast Cancer, Aortic Dissection | 87 |
| Temple University | Amyotrophic Lateral Sclerosis, COPD, Emphysema | 41 |
| The Children's Hospital of Philadelphia | Mitochondrial Diseases, Primary Mitochondrial Disease, 4H Syndrome | 40 |
| Temple University Hospital | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, COPD | 35 |
| University of Pennsylvania/Abramson Cancer Center | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 31 |
| Pennsylvania Hospital | Stroke, Acute, Activity Restriction, Advanced Cancer | 28 |
| Abramson Cancer Center of the University of Pennsylvania | Breast Cancer, Advanced Solid Tumor, DLBCL - Diffuse Large B Cell Lymphoma | 25 |
| Penn Presbyterian Medical Center | Heart Failure, ADHF, Acute Respiratory Failure | 25 |
| Jefferson Torresdale Hospital | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | 23 |
| Saint Christopher's Hospital for Children | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 22 |
| Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA | Parkinson Disease, Stress Disorders, Post-Traumatic, Advanced Urothelial Carcinoma | 19 |
| Sidney Kimmel Cancer Center at Thomas Jefferson University | Breast Cancer, Colorectal Cancer, Hormone Receptor Positive Breast Carcinoma | 16 |
| Drexel University | Autism Spectrum Disorder, Obesity, Anxiety | 13 |
| Penn Medicine | Hypertension, ALS, Allogeneic Transplantation | 13 |
| University of Pennsylvania Hospital | Chronic Lymphocytic Leukemia, Neoplasm Metastasis, Non-Hodgkin Lymphoma | 13 |
| GSK Investigational Site | Asthma, Connective Tissue Diseases, Gastrointestinal Neoplasms | 12 |
| Childrens Hospital of Philadelphia | Suicide, Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR) | 12 |
| University of Pennsylvania, Abramson Cancer Center | Advanced Solid Tumor, Biliary Tract Cancer, Breast Cancer | 12 |
| Abramson Cancer Center at University of Pennsylvania | Cardiotoxicity, Renal Cell Carcinoma, AML, Adult | 10 |
| Thomas Jefferson University, Sidney Kimmel Cancer Center | Advanced Solid Tumor, Colorectal Cancer, Bladder Cancer | 10 |
Active & Upcoming Studies in Philadelphia (2026)
Recruiting trials in Philadelphia grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (557 active studies)
- Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment · Phase 1, Phase 2 · National Cancer Institute (NCI)
- The AYA Oncology Self-care Movement · Northwestern University
Neurology & pain (111 active studies)
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
- Behavioral and/or Mirabegron to Treat Urinary Symptoms in Parkinson Disease · Phase 4 · VA Office of Research and Development
Cardiovascular (110 active studies)
- Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass-Substudy · University of Pennsylvania
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF · Phase 3 · AstraZeneca
Diabetes & metabolic (64 active studies)
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities · Phase 3 · Ascletis Pharma (China) Co., Limited
Mental health & behavior (49 active studies)
- NST-SPARK Open-Label Phase 1 STTR (IGNITE) · North Shore Therapeutics, Inc.
- Effect of cTBS on Startle and TMS-evoked BOLD · University of Pennsylvania
Pediatric (47 active studies)
- Bilevel Positive Airway Pressure (BPAP) for Severe Asthma · Columbia University
- Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). · Phase 2 · BrainChild Bio, Inc
HIV / STI (27 active studies)
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy · International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Eye & vision (23 active studies)
- Penn SICCA Follow-up Study · University of Pennsylvania
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME) · Phase 1 · Genentech, Inc.
Vaccines (6 active studies)
- Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older · Phase 1, Phase 2 · Sanofi
- Flu Infection at UPHS · University of Pennsylvania
Common conditions studied in Philadelphia
- Breast Cancer (36 active studies)
- Cancer (25 active studies)
- Ovarian Cancer (22 active studies)
- Heart Failure (21 active studies)
- Prostate Cancer (21 active studies)
- Advanced Solid Tumor (18 active studies)
Leading research sponsors in Philadelphia
- University of Pennsylvania
- Abramson Cancer Center at Penn Medicine
- Children's Hospital of Philadelphia
- Thomas Jefferson University
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Philadelphia?
There are approximately 1,987 recruiting clinical trials in Philadelphia, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Philadelphia pay participants?
Most recruiting trials in Philadelphia compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Philadelphia?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Philadelphia?
The most common conditions under active study in Philadelphia include Breast Cancer (36), Cancer (25), Ovarian Cancer (22), Heart Failure (21), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Philadelphia?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Philadelphia on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Philadelphia?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Philadelphia?
Recruiting research sites in Philadelphia include University of Pennsylvania, Children's Hospital of Philadelphia, Thomas Jefferson University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Philadelphia right now?
The largest active categories in Philadelphia are Cancer & tumors (557), Neurology & pain (111), Cardiovascular (110). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.