Paid Clinical Trials in Wilmington, NC
As of June 2026, 110 paid clinical trials are recruiting in Wilmington, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Wilmington offers studies at sites including Novant Health New Hanover Regional Medical Center for conditions such as Obesity, Degenerative Disc Disease, Diabetes Mellitus, Type 2, Heart Failure. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Wilmington
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Wilmington has approximately 110 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.
Top Research Study Locations in Wilmington
Researchers run research studies in Wilmington, NC at 50 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Novant Health New Hanover Regional Medical Center | ADHF, Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | 12 |
| Wilmington Health | Irritable Bowel Syndrome With Constipation (IBS-C), Heart Failure, Influenza | 5 |
| Accellacare Wilmington | Obesity, COPD, Diabetes Mellitus, Type 1 | 5 |
| PPD | Erosive Esophagitis, Heartburn, Helicobacter Pylori Infection | 4 |
| Accellacare | Hypersensitivity Pneumonitis, Interstitial Lung Disease, Interstitial Lung Disease Due to Connective Tissue Disease (Disorder) | 3 |
| Accellacare - Wilmington | Clostridioides Difficile Associated Disease, Diabetes Mellitus, Type 2, Viral Respiratory Illnesses | 3 |
| Atlantic Brain and Spine | Degenerative Disc Disease, Cervical Disc Disease, Cervical Disc Herniation | 3 |
| New Hanover Regional Medical Center | Atrial Fibrillation, Intracerebral Hemorrhage, Kidney Cancer | 3 |
| Wilmington Health, PLLC | Cancer, Clostridioides Difficile Associated Disease, Ulcerative Colitis (UC) | 3 |
| Accellacare and KDCILM, LLC | Obesity, Knee Osteoarthritis (OA) | 2 |
| Accellacare of Wilmington | Heart Failure With Mildly Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Non-cystic Fibrosis Bronchiectasis | 2 |
| Innovo Research - Wilmington Gastroenterology Associates | Crohn Disease, Colitis, Ulcerative | 2 |
| PMG Research of Wilmington, LLC | Type 2 Diabetes, Cortisol Excess, Diabetes Mellitus | 2 |
| Trial Management Associates - Wilmington - Floral Parkway | Obesity, Overweight, Acne | 2 |
| Accellacare (PMG) | CTCL, CTCL/ Mycosis Fungoides, Cutaneous T Cell Lymphoma | 1 |
| Accellacare - Wilmington - 1917 Tradd Court | Obesity, Overweight | 1 |
| Accellacare Research of Wilmington | Cardiovascular Disease | 1 |
| Accellacare-Wilmington-67123 | Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension | 1 |
| Altimmune Clinical Study Site | Alcohol Liver Disease | 1 |
| Ambros Clinical Trial Site | Complex Regional Pain Syndrome Type I | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
| Atlantic Brain & Spine | Brain Tumor, Brain Tumor - Metastatic, Brain Tumor, Adult Meningioma | 1 |
| Atlantic Prosthetic Services | Lower Extremity, Pareses | 1 |
| BRIUMVI® Pregnancy Registry Virtual Research Coordination Center | Multiple Sclerosis | 1 |
| Cape Fear Clinic | Hypertension | 1 |
| Cape Fear Retinal Associates | Diabetic Macular Edema | 1 |
| Cape Fear Retinal Associates, PC | DME, Diabetic Macular Edema, Diabetic Macular Edema (DME) | 1 |
| Carolina Arthritis Associates - Cliniverse Research (Network) | Active Rheumatoid Arthritis | 1 |
| Coastal Horizon | Treatment for Opioid Use Disorder | 1 |
| Coastal Vascular Institute, PA | Symptomatic Venous Thromboembolism (VTE) | 1 |
| Dermatology | Facial Skin Laxity, Skin Laxity (Submental and Neck), Submental Tissue Laxity | 1 |
| Eastern Nephrology Associates - Wilmington Office | Proteinuric Kidney Disease | 1 |
| Evidera, a PPD business unit | Migraine | 1 |
| GSK Investigational Site | HIV Infections | 1 |
| Grifols Investigative Site | Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency | 1 |
| InnovoResearch | Growth | 1 |
| KDCILM, LLC & Accellacare US, Inc. | Diabetes Mellitus, Type 2 | 1 |
| Novant Health Cancer Institute Radiation Oncology | Cancer | 1 |
| Novant Health Cancer Institute Radiation Oncology - Wilmington | Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8 | 1 |
| Novant Health New Hanover Regional Medical Center | Ventral Hernia | 1 |
| Novant Health Zimmer Cancer Institute | Multiple Myeloma | 1 |
| Novant Health Zimmer Cancer Institute - Wilmington | Melanoma | 1 |
| Oruka Therapeutics Investigative Site | Plaque Psoriasis | 1 |
| PMG Research | Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | 1 |
| PMG Research of Wilmington LLC | Obesity | 1 |
| PPD Development, LP | Plaque Psoriasis, Psoriatic Arthritis, Crohn's Disease, or Other Conditions for Which Risankizumab is an FDA-approved Treatment | 1 |
| PPD Virtual | CIDP, CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy), Chronic Inflammatory Demyelinating Polyradiculoneuropathy | 1 |
| PPD Virtual - PPD - US | Schizophrenia | 1 |
| PPD, Inc. | Narcolepsy, Obstructive Sleep Apnea, Pregnant Women and Their Offspring | 1 |
| PROVIDE Virtual Research Coordination Center | Relapsing Multiple Sclerosis | 1 |
Active & Upcoming Studies in Wilmington (2026)
Recruiting trials in Wilmington grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Diabetes & metabolic (16 active studies)
Cancer & tumors (14 active studies)
- Incorporating Biometric Data for Patients Receiving Concurrent Chemotherapy & RT · UNC Lineberger Comprehensive Cancer Center
- ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab · Phase 3 · Alliance for Clinical Trials in Oncology
Cardiovascular (11 active studies)
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
- EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease · Phase 3 · Boehringer Ingelheim
Neurology & pain (5 active studies)
- Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) · Phase 3 · Ambros Therapeutics, Inc.
- A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS) · TG Therapeutics, Inc.
Vaccines (2 active studies)
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- RSV Vaccine Pregnancy Registry · CorEvitas
HIV / STI (2 active studies)
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · ViiV Healthcare
- Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People. · Syneos Health
Mental health & behavior (2 active studies)
- Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT) · Bristol-Myers Squibb
- Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder · Phase 3 · Vanda Pharmaceuticals
Eye & vision (2 active studies)
- COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME · Phase 3 · Hoffmann-La Roche
Common conditions studied in Wilmington
- Obesity (9 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Cancer (3 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Degenerative Disc Disease (3 active studies). Recruiting Degenerative Disc Disease studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Diabetes Mellitus, Type 2 (3 active studies). Diabetes trials evaluate new insulin formulations, GLP-1 receptor agonists, continuous glucose monitoring technologies, and disease-modifying therapies.
- Heart Failure (3 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Overweight (3 active studies). Recruiting Overweight studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Wilmington
- Novo Nordisk A/S
- AstraZeneca
- Eli Lilly and Company
- AbbVie
- Bristol-Myers Squibb
Local regulations and guidelines
Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Wilmington. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Wilmington
Hipa.ai aggregates every recruiting study in Wilmington from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Wilmington?
There are approximately 110 recruiting clinical trials in Wilmington, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Wilmington pay participants?
Most recruiting trials in Wilmington compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Wilmington?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Wilmington?
The most common conditions under active study in Wilmington include Obesity (9), Cancer (3), Degenerative Disc Disease (3), Diabetes Mellitus, Type 2 (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Wilmington?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Wilmington on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Wilmington?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Wilmington?
Recruiting research sites in Wilmington include Novant Health New Hanover Regional Medical Center, Wilmington Health, Accellacare Wilmington, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Wilmington right now?
The largest active categories in Wilmington are Diabetes & metabolic (16), Cancer & tumors (14), Cardiovascular (11). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.