Cardiovascular disease (general) Clinical Trials

Recruiting cardiovascular disease (general) studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat cardiovascular disease (general). Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting cardiovascular disease (general) studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting cardiovascular disease (general) trials

Within

Effect of Propionic Acid Supplementation on Endothelial Function

for Cardiovascular Diseases

Sponsor: Medical College of Wisconsin

Sex: All·Age: 40 - 75

Code: NCT05135702

TA-65 and Aging Associated Microvascular Dysfunction

for Telomere Shortening

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05598359

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

for Cardiovascular Diseases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06320951·Phase 2

Enhancing Mental and Physical Health of Women Veterans 3.0

for Cardiovascular Diseases

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07356479

Estrogen Deficiency on Cardiovascular Risk

for Postmenopausal Symptoms

Sponsor: Milton S. Hershey Medical Center

Sex: Female·Age: 54 - 75·Accepts healthy volunteers

Code: NCT06369363·EARLY_Phase 1

Impact of Combined Cardio-pulmonary Assessment on COPD Clinical Management.

for COPD (Chronic Obstructive Pulmonary Disease)

Sponsor: University of Bari Aldo Moro

Sex: All·Age: 41+

Code: NCT07481825

Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury

for Spinal Cord Injuries

1 site in West Orange

Sponsor: Kessler Foundation

Sex: All·Age: 18 - 75

Code: NCT07674511

Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.

for Cardio-pulmonary Bypass

Sponsor: Nicosia General Hospital

Sex: All·Age: 40 - 80

Code: NCT06995586

WomenFocused Education in CArdiac REhabilitation (WECARE) Pilot RCT

for Cardiovascular Diseases

Sponsor: University Health Network, Toronto

Sex: Female·Age: 18+

Code: NCT07550036

A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation.

for Tricuspid Valve Disease

35 sites incl. Birmingham

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18 - 85

Code: NCT06458907

Evaluation of a Novel Indoor Air Pollution Intervention Among Older Adults

for Cardiovascular Diseases

1 site in Missoula

Sponsor: University of Montana

Sex: All·Age: 55 - 79

Code: NCT07539987

Evaluation of Anxiety Reduction in the Cathlab by Means of Pharmacological and Non-pharmacological Strategies

for Cardiovascular Disease

Sponsor: Olivier F. Bertrand

Sex: All·Age: 18+

Code: NCT07681180

TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)

for Heart Valve Diseases

1 site in Carmel

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT07684313

A Study Exploring the Effect of Adjuvanted RZV or RSVPreF3 Vaccines on Coronary Plaque Progression in Adults >=50 Years of Age at Risk for Cardiovascular Events

for Cardiovascular Disease

Sponsor: GlaxoSmithKline

Sex: All·Age: 50+

Code: NCT07712380·Phase 2

Palmitic Acid and Human Microvascular Function

for Microvascular Dysfunction

1 site in Wauwatosa

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18 - 40

Code: NCT06683534·Phase 2

Free Fatty Acid Effects In Type 2 Diabetes

for Type 2 Diabetes

Sponsor: University of Ulster

Sex: All·Age: 18+

Code: NCT07677995

Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease

for Caregiver Burden

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18+

Code: NCT07717723

Apply to this trial

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

for Pulmonary Hypertension

3 sites incl. Houma

Sponsor: Pulnovo Medical, Inc.

Sex: All·Age: 18 - 85

Code: NCT07214376

Apply to this trial

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

for Stroke

1 site in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 99

Code: NCT06615973

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Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

for Allogeneic Stem Cell Transplantation

1 site in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT07613099·Phase 3

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Pilot Study to Evaluate a Noninvasive Electrocardiographic Monitoring Strategy Associated With Early Discharge in Patients With Conduction Disorders Following TAVI Implantation (IMPROVE Study)

for Severe Aortic Valve Stenosis

Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Sex: All·Age: 18+

Code: NCT07456280

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Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy

for Hypertension, Pregnancy Induced

1 site in Salt Lake City

Sponsor: University of Utah

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05826925

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In-Hospital Wearable-Based Monitoring Versus Standard Care in Cardiovascular Disease (INSPIRE)

for Cardiovascular Diseases

Sponsor: Yonsei University

Sex: All·Age: 20+

Code: NCT07622485

Association Between 4D MRI Parameters and the Clinical Characteristics and Prognosis of Major Chronic Diseases

for Cardiovascular Disease

Sponsor: Ulsan University Hospital

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT07678606

Study on Intervention Effect of Heat-related Health Risk Early Warning Digital Technology for School-age Children

for Cardiovascular Diseases

Sponsor: Centers for Disease Control and Prevention, China

Sex: All·Age: 9 - 11·Accepts healthy volunteers

Code: NCT07643571

Efficacy and Safety of Antihypertensive Treatment With Mobile Stroke Units in Ultra-Early Intracerebral Hemorrhage

for Nervous System Diseases

Sponsor: Xuanwu Hospital, Beijing

Sex: All·Age: 18+

Code: NCT07665827

Risk Prediction Scores for Cardiotoxicity in Cancer Patients Treated With Cardiotoxic Anticancer Therapies in Europe

for Cancer

Sponsor: University Hospital, Caen

Sex: All·Age: 18+

Code: NCT07621289

Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

for Coronary Disease

1 site in Washington D.C.

Sponsor: Teleflex

Sex: All·Age: 18 - 80

Code: NCT07258290

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Health Ahead Comparative Effectiveness Study

for Health Services Accessibility

1 site in Boulder

Sponsor: William Brandenburg, MD

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07669168

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Effect of Visual Presentation of Atherosclerotic Plaque on Modification of Arterial Hypertension One Year Postpartum in Women With a History of Adverse Pregnancy Outcomes, and Risk Customization With AI Prediction Algorithms

for Adverse Pregnancy Outcomes

Sponsor: Maternal-Infantil Vall d´Hebron Hospital

Sex: Female·Age: 18+

Code: NCT06798649

Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

for Atrial Fibrillation

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT06938412

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A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

for Atherosclerosis

17 sites incl. La Jolla

Sponsor: Eli Lilly and Company

Sex: All·Age: 45 - 80

Code: NCT07613294·Phase 3

Apply to this trial

A Cluster Randomized Trial of a Telemedicine-Enabled Integrated Care Model for Stroke Prevention and Management in Rural Elderly Adults in China

for Stroke

Sponsor: Jiangsu Province (Suqian) Hospital

Sex: All·Age: 65+

Code: NCT07628283

BAG3-DCM Natural History Study

for Dilated Cardiomyopathy (DCM)

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT07486752

Effectiveness of Pollution Monitoring in Clinical Exercise Rehabilitation

for Cardiovascular Disease

Sponsor: University of Leicester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07500948

Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD

for Renal Insufficiency

Sponsor: Yonsei University

Sex: All·Age: 19 - 85

Code: NCT07524101

Apply to this trial

Measurements Before and After Participation in a Health Intervention Programme in Halsnaes Municipality

for Type 2 Diabetes

Sponsor: Steno Diabetes Center Copenhagen

Sex: All·Age: 18+

Code: NCT07641309

Apply to this trial

Regional Innovation in Chronic Disease and Elderly Care

for Hypertension

Sponsor: Fu Jen Catholic University

Sex: All·Age: 18+

Code: NCT07578090

Apply to this trial

Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)

for CKD

Sponsor: University Medical Center Groningen

Sex: All·Age: 18+

Code: NCT07304817·Phase 2

Apply to this trial

Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation

for Cardiovascular Diseases

Sponsor: Imperial College London

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06061822

Apply to this trial

Vital Signs Blood Pressure Trial

for Cardiovascular Diseases

Sponsor: Stanford University

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT06272318

Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients

for Cardiovascular Disease

Sponsor: Unity Health Toronto

Sex: All·Age: 18+

Code: NCT07507409·Phase 4

Longitudinal Validation of CIRC Technologies

for Cardiovascular Diseases

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07081711

The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure

for Fontan

Sponsor: The University of Hong Kong

Sex: All·Age: 12+

Code: NCT07482943·Phase 4

Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia

for Cardiovascular Disease

Sponsor: Tor Biering-Sørensen

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07485283·Phase 4

Apply to this trial

Human Observatory Study

for Aging

1 site in Boulder

Sponsor: Longevity Metrics, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07646782

Apply to this trial

Feasibility of The Health Integrated Nutrition and Kidney Wellness Program

for Chronic Kidney Disease

5 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07518719

Apply to this trial

The PreEclampsia Postpartum Prevention Trial

for Preeclampsia

Sponsor: Karolinska Institutet

Sex: Female·Age: 18+

Code: NCT07199283

Apply to this trial

Stress Reactivity and Mother-Infant Cardiovascular Disease Risk

for Maternal Health

1 site in Providence

Sponsor: Lifespan

Sex: Female·Age: 6 Months+·Accepts healthy volunteers

Code: NCT06805799

Awareness of Risk Factors and Perception of Cardiovascular Risk in Secondary Prevention Among Women and Men

for Cardiovascular Disease

Sponsor: Istituti Clinici Scientifici Maugeri SpA

Sex: All·Age: 18+

Code: NCT07521436

Apply to this trial

Self Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD)

for Angina Pectoris

3 sites incl. New Haven

Sponsor: VahatiCor, Inc.

Sex: All·Age: 18+

Code: NCT07449325

Apply to this trial

Effect of Neurofast® Supplementation on Anxiety and Cardiovascular Outcomes in the Psycho-Cardio Phenotype Adults

for Anxiety

Sponsor: Liaquat University of Medical & Health Sciences

Sex: All·Age: 18 - 70

Code: NCT07502807

Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery

for Cardiovascular Surgical Procedures

Sponsor: Ordu University

Sex: All·Age: 18 - 70

Code: NCT07557108

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A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab

for Cardiovascular Diseases

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 99

Code: NCT07543731

Apply to this trial

AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases

for Diabetes Mellitus Type 2

Sponsor: Jae Yong Jeon, MD

Sex: All·Age: 30 - 60·Accepts healthy volunteers

Code: NCT07595718

Apply to this trial

SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation

for Cardiovascular Diseases

1 site in Providence

Sponsor: The Miriam Hospital

Sex: All·Age: 18+

Code: NCT06886789

Apply to this trial

PKP2-ACM Natural History Study

for Cardiomyopathies

2 sites incl. Boston

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06644742

Apply to this trial

Vbeam Pro Pulse Dye Laser for the Treatment of Vascular Conditions

for Rosacea

Sponsor: Candela Corporation

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07290426

DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies

for Cardiovascular Diseases

Sponsor: Cambridge University Hospitals NHS Foundation Trust

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07483801·Phase 4

A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

for Hypertension

3 sites incl. Farmington

Sponsor: University of Connecticut

Sex: All·Age: 18 - 64

Code: NCT07238556

Apply to this trial

Cardiovascular disease (general) clinical trials — common questions

Are cardiovascular disease (general) clinical trials free to join?

Yes. Participating in a cardiovascular disease (general) clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a cardiovascular disease (general) clinical trial?

Each cardiovascular disease (general) study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a cardiovascular disease (general) trial near me?

Use the location controls above. We'll show recruiting cardiovascular disease (general) trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many cardiovascular disease (general) trials are recruiting right now?

We're currently tracking roughly 211 recruiting cardiovascular disease (general) trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Cardiovascular disease (general) trials by city

Boston, MA Birmingham, AL Cleveland, OH San Francisco, CA Aurora, CO Chicago, IL Boulder, CO Columbus, OH La Jolla, CA Sacramento, CA Ann Arbor, MI Los Angeles, CA

Related specialties

Cardiology Heart disease