Insulin resistance Clinical Trials

Recruiting insulin resistance studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat insulin resistance. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting insulin resistance studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting insulin resistance trials

Within

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

The Simplified Total-body Resistance Exercise for Muscular Hypertrophy for Diabetic Population (D-STORM)

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Universiti Teknologi Mara

Sex: All·Age: 18 - 65

Code: NCT07664501

"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"

for Diabetes Mellitus, Type 2

Sponsor: Escuela Universitaria de Osuna

Sex: All·Age: 30 - 65

Code: NCT07685080

Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.

for Chronic Pain

Sponsor: São Paulo State University

Sex: Female·Age: All ages

Code: NCT07407699

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

for Obesity (BMI>30)

1 site in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07653464·EARLY_Phase 1

Effects of Exercise Sequence and Meal Sequence on Weight Management Among Children and Adolescents With Overweight or Obesity: The STEP Trial

for Obesity & Overweight

Sponsor: Peking University

Sex: All·Age: 10 - 17·Accepts healthy volunteers

Code: NCT07712068

Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity

for Insulin Resistance

1 site in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05713799·Phase 2

DIabetes GLycemic Assessment in Newly Confirmed Episodes

for Type 2 Diabetes (T2DM)

Sponsor: Nazarii Kobyliak

Sex: All·Age: 18+

Code: NCT07690163

Apply to this trial

Effect of Insulin Lowering on Lipogenesis

for Hyperinsulinemia

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT07403604·Phase 1

Apply to this trial

Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance

for Shift Work Schedule

1 site in Spokane

Sponsor: Washington State University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07494084·Phase 4

PREdiabetes GLycemic Impact and Data Evaluation

for Pre Diabetic

Sponsor: Nazarii Kobyliak

Sex: All·Age: 18+

Code: NCT07599072

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Determining Cell- and Spatially-distinct Skeletal Muscle Transcriptional Aberrations in Insulin Resistance

for Insulin Resistance

1 site in Orlando

Sponsor: AdventHealth Translational Research Institute

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT07516509

Validation of the Snouda Metabolic Score for Phenotyping and Guiding Reversal in Type 2 Diabetes

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Salah Snouda

Sex: All·Age: 18+

Code: NCT07606872

Food and Metabolism Study

for Prediabetes

1 site in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT07624500

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Insomnia and Insulin Resistance

for Insomnia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07333586

Kodo Millet Porridge and Its Effects on Gut Health and Metabolic Syndrome

for Obesity & Overweight

Sponsor: JSS MEDICAL COLLEGE, JSS ACADEMY OF HIGHER EDUCATION AND RESEARCH

Sex: All·Age: 20 - 60

Code: NCT07703371

Apply to this trial

The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV

for HIV

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07226128

Apply to this trial

Impact of a Probiotic Supplementation With Lifestyle Modification on Liver Steatosis, Fibrosis, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

for Liver Elastography

Sponsor: Fu Jen Catholic University Hospital

Sex: All·Age: 18 - 80

Code: NCT07400367

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Insulin Resistance as a Predictor of Pulsed Field Ablation Success in Atrial Fibrillation (HOMA-PULSE)

for Atrial Fibrillation

Sponsor: Nemocnice AGEL Trinec-Podlesi a.s.

Sex: All·Age: 18+

Code: NCT07551947

Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)

for Cardiovascular Risk Factors

Sponsor: Nemocnice AGEL Trinec-Podlesi a.s.

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07551960

Empagliflozin Adjunctive Therapy in Bipolar Depression

for Bipolar Disorder

Sponsor: University of Sao Paulo

Sex: All·Age: 18 - 65

Code: NCT07472920

MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity

for Prediabetes

Sponsor: Hudson Biotech

Sex: All·Age: 18 - 65

Code: NCT07505745·Phase 2

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Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

for Insulin Resistance

1 site in San Francisco

Sponsor: SF Research Institute, Inc.

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT07220694

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SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)

for Polycystic Ovary Syndrome (PCOS)

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07396402

Glucose Profiles in Women With Polycystic Ovary Syndrome

for Polycystic Ovary Syndrome

Sponsor: Centre Hospitalier Universitaire, Amiens

Sex: Female·Age: 18+

Code: NCT07483723

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Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects

for Prediabetic State

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18 - 75

Code: NCT07377097

Cardiometabolic Disease and Substrate Metabolism

for Preeclampsia

1 site in Knoxville

Sponsor: University of Tennessee Graduate School of Medicine

Sex: Female·Age: 18 - 45

Code: NCT07565727

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Effects of Ketone Bodies on Insulin Sensitivity

for Insulin Resistance

Sponsor: University of Aarhus

Sex: All·Age: 55 - 70·Accepts healthy volunteers

Code: NCT07359625

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ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence

for PCOS (Polycystic Ovary Syndrome)

1 site in Somerville

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 8+

Code: NCT07102797

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Impact of Starch Digestibility on Glycemic Variability and Control, Cardiometabolic and Inflammatory Profiles, Microbiota and Intestinal Health in Subjects With Insulin Resistance

for Insulin Resistance

Sponsor: Mondelēz International, Inc.

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07408479

Apply to this trial

New Mechanisms of Obesity

for Obesity and Overweight

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 15 - 22

Code: NCT06768827

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Effect of Add-on SGLT2i, TZD, or Combination Therapy in Type 2 Diabetes Patients on DPP4 Inhibitors

for Diabetes Mellitus, Type 2

Sponsor: Yonsei University

Sex: All·Age: 19 - 75

Code: NCT07108985·Phase 4

Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults

for Muscular Atrophy

Sponsor: Queen's University

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT07178353

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Efficacy of NOSHINtrial in Diabetic Patients

for Diabetes Mellitus, Type 2

Sponsor: Kerman Medical University

Sex: All·Age: 20 - 65·Accepts healthy volunteers

Code: NCT06205030·Phase 4

A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents

for Obesity, Adolescent

3 sites incl. Bloomington

Sponsor: Nana Gletsu Miller

Sex: All·Age: 12 - 18·Accepts healthy volunteers

Code: NCT07223151

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Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)

for Obesity and Cardiovascular Risk

Sponsor: University Of Nigeria Teaching Hospital

Sex: All·Age: 20 - 59

Code: NCT07297290·Phase 3

Apply to this trial

Effects of Cranberry on Gut and Metabolic Health

for Overweight/Obesity

Sponsor: Laval University

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT07460856

Apply to this trial

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

for Obesity

2 sites incl. Boston

Sponsor: Pichamol Jirapinyo, MD, MPH

Sex: All·Age: 18+

Code: NCT06138821

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Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Patients with Gestational Diabetes

for Gestational Diabetes Mellitus (GDM)

Sponsor: University of Kasdi Merbah

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06860087·Phase 1, Phase 2

Photoacoustic/Ultrasound Imaging of Brown Adipose Tissue Activity

for Insulin Resistance

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07327684

Apply to this trial

The Muscle Monitor: Early Skeletal Muscle Indicators of Insulin Resistance and Cardiometabolic Risk

for Insulin Resistance

Sponsor: University Ghent

Sex: All·Age: 20 - 30

Code: NCT07678736

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Metabolic Effects of Linoleic Acid-Rich Oil Compared to a Blend Oil in Adults With Insulin Resistance

for Insulin Resistance

Sponsor: Pontificia Universidad Catolica de Chile

Sex: All·Age: 20 - 60

Code: NCT07287514

Apply to this trial

Hepatic Elastography-Enhanced Lifestyle Modification in MASLD

for Transient Elastography

Sponsor: Mahidol University

Sex: All·Age: 18 - 80

Code: NCT06826807

Effect of Tele-exercise on Cardiorespiratory Fitness in Paediatrics

for Cardiorespiratory Fitness

Sponsor: KK Women's and Children's Hospital

Sex: All·Age: 12 - 17

Code: NCT06770660

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The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old

for Insulin Resistance

Sponsor: University of Jordan

Sex: All·Age: 18 - 40

Code: NCT06911918

Efficacy and Safety of Vitamin D Supplementation in Pediatric Patients with Obesity

for Vitamin D

Sponsor: Coordinación de Investigación en Salud, Mexico

Sex: All·Age: 10 - 18

Code: NCT06847373

Apply to this trial

A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

for Healthy

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 60 - 85·Accepts healthy volunteers

Code: NCT06820658

Apply to this trial

NUTRITIONAL INTERVENTION STUDY to EVALUATE the EFFECT of ACHETA DOMESTICUS POWDER CONSUMPTION on GLUCOSE HOMEOSTASIS and INTESTINAL DYSBIOSIS in HEALTHY and PREDIABETIC POPULATION.

for Insulin Resistance

Sponsor: María Isabel Espinosa

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06622616

Insulin Resistance in Egyptian Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 18 - 50

Code: NCT06017726

Diazoxide Suppression Test P&F Study

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06606327·Phase 1

Apply to this trial

Alternative Physical Activity Strategies for Breast Cancer Survivors

for Breast Cancer

Sponsor: University of Toronto

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06633380

Apply to this trial

Insulin Resistance and Resisted Exercise Post Burn

for Insulin Resistance

Sponsor: Cairo University

Sex: All·Age: 18 - 35

Code: NCT06654908

Electro-Acupuncture for Obese Patients With Insulin Resistance

for Obesity

Sponsor: Nanyang Technological University

Sex: All·Age: 21 - 65

Code: NCT06609200

Apply to this trial

Graded Insulin Suppression Test P&F

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06592261·Phase 1

Apply to this trial

Neuromuscular Electrical Stimulation: A Novel Treatment for Improving Metabolism

for Insulin Resistance

1 site in El Paso

Sponsor: University of Texas, El Paso

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06722391

Apply to this trial

The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD.

for Daily Step Count

Sponsor: Mahidol University

Sex: All·Age: 18+

Code: NCT06334666

Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness

for Normal Weight

Sponsor: University Hospital Tuebingen

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06487832

Apply to this trial

Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease

for Coronary Microvascular Dysfunction

Sponsor: Azienda Ospedaliera Universitaria Integrata Verona

Sex: All·Age: 18+

Code: NCT06597851

Apply to this trial

Effects of Antipsychotics on Brain Insulin Action in Females

for Insulin Resistance

Sponsor: Centre for Addiction and Mental Health

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06251635

Apply to this trial

Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）

for Type 2 Diabetes

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 45 - 70·Accepts healthy volunteers

Code: NCT06912321

Apply to this trial

Insulin resistance clinical trials — common questions

Are insulin resistance clinical trials free to join?

Yes. Participating in a insulin resistance clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a insulin resistance clinical trial?

Each insulin resistance study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a insulin resistance trial near me?

Use the location controls above. We'll show recruiting insulin resistance trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many insulin resistance trials are recruiting right now?

We're currently tracking roughly 38 recruiting insulin resistance trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Insulin resistance trials by city

Ann Arbor, MI Aurora, CO Stanford, CA Bloomington, IN Boston, MA Chicago, IL Indianapolis, IN Orlando, FL Palo Alto, CA Sacramento, CA Salt Lake City, UT San Francisco, CA

Related specialties

Endocrinology Metabolic health