Clinical Trials at Duke University Health System
As of August 2026, 40 paid clinical trials are recruiting at Duke University Health System, located at DUKE UNIVERSITY DUMC 3470, ENDOCRINOLOGY DEPARTMENT C/OTRACI WOMBLE, DURHAM, NC 27710, phone (919) 668-4289 in Durham, North Carolina. Active studies at this site cover conditions such as Heart Failure, Breast Cancer and Prostate Cancer. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Durham
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
41 clinical trials at Duke University Health System
·Clear filters·OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Study of Olutasidenib and Temozolomide in HGG
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial
Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia
Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)
Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network
IL-17 Blockade to Decrease irAEs (REPLAY)
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers
Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease
Risk Stratification in Children With Concussion
Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
Targeted Pediatric High-Grade Glioma Therapy
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Development & Validation of Preoperative Objective Physiological Evaluation
HCMT/MM2401: Ph2 Study of Selinexor + Bispecific Antibody for RRMM
The WISER Study: Web Based Methods for Enhancing Resilience
Complex Adult Deformity Surgery (CADS)
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs
Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia
Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0
Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery
Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients
Duke Customized Aortic Aneurysm Repair With Endovascular Stent-grafts - Duke CARES Trial
HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT
Excision of Lymph Node Trial (EXCILYNT) (Mel69)
Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Common conditions studied in Durham
- Heart Failure (20 active studies)
- Breast Cancer (19 active studies)
- Prostate Cancer (16 active studies)
- Cancer (12 active studies)
- Acute Myeloid Leukemia (11 active studies)
- Stroke (11 active studies)
Leading research sponsors in Durham
- Duke University
- VA Office of Research and Development
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Durham?
There are approximately 1,044 recruiting clinical trials in Durham, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Durham pay participants?
Most recruiting trials in Durham compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Durham?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Durham?
The most common conditions under active study in Durham include Heart Failure (20), Breast Cancer (19), Prostate Cancer (16), Cancer (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Durham?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Durham on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Durham?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Durham?
Recruiting research sites in Durham include Duke University Medical Center, Duke University, Duke University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Durham right now?
The largest active categories in Durham are Cancer & tumors (286), Cardiovascular (95), Neurology & pain (67). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Duke University Health System?
Duke University Health System is located at DUKE UNIVERSITY DUMC 3470, ENDOCRINOLOGY DEPARTMENT C/OTRACI WOMBLE, DURHAM, NC 27710. Use the Google Maps link in the intro above to get directions.
How do I contact Duke University Health System?
You can reach Duke University Health System by phone at (919) 668-4289. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.