Frailty Clinical Trials

Recruiting frailty studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat frailty. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting frailty studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting frailty trials

Within

Frailty Improvement Through Technology With Informal Caregiver Supported Exercise (FITWISE) for Pre-frail and Frail Community-dwelling Older Adults

for Frailty

Sponsor: National University of Singapore

Sex: All·Age: 21 - 99·Accepts healthy volunteers

Code: NCT07519642

Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients

for Frailty

Sponsor: Stanford University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT04658160

Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome

for Frailty

Sponsor: Miracle Biomedical Co., Ltd.

Sex: All·Age: 60 - 85

Code: NCT07705464·Phase 1

Older Adults' Recovery Dynamics After Cardiac Surgery

for Frailty

Sponsor: University of Chile

Sex: All·Age: 65+

Code: NCT07793708

Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients

for Frailty

Sponsor: University of Sao Paulo General Hospital

Sex: All·Age: 60+

Code: NCT07742475

MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10

for Frailty

Sponsor: University Medical Centre Ljubljana

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07772336

In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults

for Frailty

Sponsor: University of Cadiz

Sex: All·Age: 65+

Code: NCT07738393

The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases

for Frailty

Sponsor: Hospital Universitari de Bellvitge

Sex: All·Age: 18+

Code: NCT07663955

STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging

for Sarcopenia

Sponsor: University of Leicester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07726498

BIOANCIENT_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial.

for Aging

Sponsor: Fundacion Miguel Servet

Sex: All·Age: 100+

Code: NCT07723339

Development of a Frailty Risk Prediction Model and Preliminary Evaluation of a Risk-stratified Social Robot-assisted Intervention in Middle-aged and Older Spousal Caregivers

for Frailty

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 50+

Code: NCT07740031

Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery

for Frailty

Sponsor: University of Alberta

Sex: All·Age: 50+

Code: NCT05977556

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Evolution of Physical Frailty and Patient-Reported Outcome Measures in Kidney Transplant Candidates: A Mixed-Methods Longitudinal Study Protocol

for Kidney Failure, Chronic

Sponsor: Hospital del Mar

Sex: All·Age: 18+

Code: NCT07607041

Remote vs In-Person Prehabilitation for Kidney Transplant Candidates

for Chronic Kidney Disease (CKD)

Sponsor: Hospital Clinic of Barcelona

Sex: All·Age: 18+

Code: NCT07701382

Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition

for Frailty

Sponsor: Federal University of Rio Grande do Sul

Sex: All·Age: 90+

Code: NCT07731529

Frailty and Ultrasound-Guided Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients

for Frailty

Sponsor: Ankara City Hospital Bilkent

Sex: All·Age: 18+

Code: NCT07701538

Exercise-based Frailty Intervention in Lung Transplantation (XFIT)

for Frailty

4 sites incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 75

Code: NCT06960421

EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery

for Hypotension on Induction

Sponsor: Konya City Hospital

Sex: All·Age: 18+

Code: NCT07642765

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Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders

for Malnutrition

Sponsor: University Psychiatric Clinic Ljubljana

Sex: All·Age: 65+

Code: NCT07710456

Analgesia Methods and Early Mobilization in Geriatric ICU Patients After Major Surgery

for Postoperative Pain

Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Sex: All·Age: 65+

Code: NCT07709975

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Health Ahead Comparative Effectiveness Study

for Health Services Accessibility

1 site in Boulder

Sponsor: William Brandenburg, MD

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07669168

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Nurse-Led Telehealth Frailty Management in Older Adults

for Frailty

Sponsor: Kutahya Health Sciences University

Sex: All·Age: 65+

Code: NCT07634406

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Silkworm Pupa Powder Improves Alzheimer's Disease

for Alzheimer Disease

Sponsor: Zhejiang Provincial Tongde Hospital

Sex: All·Age: 50 - 90

Code: NCT07638449

ERAS Compliance and Nutritional Outcomes After Open Heart Surgery

for Cardiac Surgery

Sponsor: Bursa City Hospital

Sex: All·Age: 18 - 85

Code: NCT07783204

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Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?

for Osteoporosis

Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Sex: Female·Age: 45+

Code: NCT07677072

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Human Observatory Study

for Aging

1 site in Boulder

Sponsor: Longevity Metrics, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07646782

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Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic

for Frailty

Sponsor: Tomas Bata Hospital, Czech Republic

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07432009

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Tele-Rehabilitation in Adults With Cystic Fibrosis

for Cystic Fibrosis

Sponsor: King Saud University

Sex: All·Age: 18+

Code: NCT07500493

Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis

for Cirrhosis

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07029243

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Multicomponent Exercise and Virtual Reality for Older Adults

for Frailty

Sponsor: European University Miguel de Cervantes

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07529743

Telehealth-Supported Discharge Programme for Frail Older Adults

for Frailty

Sponsor: Chinese University of Hong Kong

Sex: All·Age: 65+

Code: NCT07490847

Benefits of Strength Training in Informal Caregivers of Patients With Alzheimer's Disease

for Frailty

Sponsor: University of Salamanca

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07388186

Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Guangdong Provincial People's Hospital

Sex: All·Age: 75+

Code: NCT07441382

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G8 Screening Tool Validation in Older Adults With Cancer in Portugal

for Cancer

Sponsor: Hospital de Braga

Sex: All·Age: 70+

Code: NCT07487298

Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery

for Hip Fracture

Sponsor: Trakya University

Sex: All·Age: 60+

Code: NCT07481188

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Preoperative Oral Nutrition And Outcomes In Frail Elderly Patients With Femur Fractures

for Femoral Fractures

Sponsor: Duzce University

Sex: All·Age: 65+

Code: NCT07463352

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Comprehensive Geriatric Assessment in Adults Aged 40 Years and Older Living With HIV

for Frailty

Sponsor: Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT07453303

Association Between Geriatric Frailty and Medication Related Problems in the Emergency Department to Help Clinical Pharmacists Prioritise Patients

for Frailty

Sponsor: Pharmacie des Hopitaux de l'Est Lemanique

Sex: All·Age: 75+

Code: NCT07282379

Chronic and Acute Cardiovascular Diseases in Elderly Intensive Care Patients

for Chronic Cardiovascular Disease

Sponsor: Heinrich-Heine University, Duesseldorf

Sex: All·Age: 80+

Code: NCT07385482

AI-Enabled Frailty Risk Prediction in Adult Congenital Heart Disease

for Adult Congenital Heart Disease

Sponsor: Mackay Memorial Hospital

Sex: All·Age: 20+

Code: NCT07479654

Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Program

for Chronic Obstructive Pulmonary Disease (COPD)

Sponsor: National Geriatric Hospital

Sex: All·Age: 60+

Code: NCT07519603

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Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients

for Chronic Disease

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07391046

BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4

for Sarcopenia

2 sites in Chapel Hill

Sponsor: SynchroHealth LLC

Sex: All·Age: 65+

Code: NCT07421648

Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

for Aging

1 site in Beverly Hills

Sponsor: Scott Silveira

Sex: All·Age: 60 - 80·Accepts healthy volunteers

Code: NCT07144527

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Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nursing Homes (MOVE4CARE)

for Frailty

Sponsor: Universidade do Porto

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07392944

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Ready for Safe Cancer Treatment (RESET): A Comprehensive Perioperative Program for Surgical Oncology

for Neoplasms

Sponsor: Regional Specialist Hospital in Wroclaw

Sex: All·Age: 18+

Code: NCT07727876

Apply to this trial

Physiotherapy Interventions on Functional Capacity, Balance and Mental Domains in Community-Dwelling Older Adults: A Randomized Clinical Trial With Two Parallel Groups

for Ageing

Sponsor: Aveiro University

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07424274

BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)

for Aging

Sponsor: Fundacion Miguel Servet

Sex: All·Age: 100+

Code: NCT07707297

Apply to this trial

Older Kidney Patient Optimisation Pretransplant

for Kidney Disease

Sponsor: Guy's and St Thomas' NHS Foundation Trust

Sex: All·Age: 60+

Code: NCT07419945

The Effect of Volunteer-Engaged Lifestyle Optimisation Via ICOPE on Sarcopenia in Older Adults (VELO-S)

for Sarcopenia

Sponsor: The University of Hong Kong

Sex: All·Age: 60+

Code: NCT07345832

Apply to this trial

Ultrasound, Nutritional Status, and Outcomes in Surgical ICU

for Nutritional Status

Sponsor: Osijek University Hospital

Sex: All·Age: 18+

Code: NCT07475767

Apply to this trial

FreeFrail Project: A Multicomponent Intervention for the Management of Frailty in Primary Care: A Randomized Controlled Trial

for Frail Elderly

Sponsor: Universitat de Lleida

Sex: All·Age: 65+

Code: NCT07205016

Elderly Health Profile in a Rural Village of Assiut

for Chronic Diseases in Older Adults

Sponsor: Assiut University

Sex: All·Age: 60+

Code: NCT07263087

Supporting Uptake of Evidence for Physical Activity in Older Adults With Complex Health Care Needs

for Frailty

Sponsor: University of British Columbia

Sex: All·Age: Up to 99

Code: NCT06894914

Apply to this trial

Predicting of Frailty

for Femur Fractures

Sponsor: ali ihsan uysal

Sex: All·Age: 65+

Code: NCT07332052

Comprehensive Geriatric Assessment in Primary Care

for Frailty

Sponsor: Nova Scotia Health Authority

Sex: All·Age: 65+

Code: NCT07341061

A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle Health in Older Adults

for Aging

Sponsor: Changi General Hospital

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07205133

Apply to this trial

Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation

for End-stage Liver Disease

Sponsor: Kalliopi Anna Poulia

Sex: All·Age: 18 - 70

Code: NCT07561138

Apply to this trial

Patient-centered REhabilitation Program to Advance REcovery

for Cancer

Sponsor: Korea University Anam Hospital

Sex: All·Age: 19+

Code: NCT07189000

Virtual Reality-Based vs Traditional Physiotherapy for Balance, Frailty, and Fall Prevention in Adults Aged 45 Years and Older

for Frailty

Sponsor: Umm Al-Qura University

Sex: All·Age: 40+

Code: NCT07322861

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Frailty clinical trials — common questions

Are frailty clinical trials free to join?

Yes. Participating in a frailty clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a frailty clinical trial?

Each frailty study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a frailty trial near me?

Use the location controls above. We'll show recruiting frailty trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many frailty trials are recruiting right now?

We're currently tracking roughly 26 recruiting frailty trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Frailty trials by city

Boulder, CO Chicago, IL San Francisco, CA Aurora, CO Beverly Hills, CA Columbus, OH Jacksonville, FL

Related specialties

Geriatrics