Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in Charlotte +47 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
Women's health Clinical Trials in Charlotte, NC
As of August 2026, 27 paid clinical trials are recruiting for Women's health in Charlotte, North Carolina. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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27 clinical trials for Women's health
·Clear filters· Email me when a new women's health trial opens in Charlotte, NC.
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
for Ovarian Cancer
Drug: INCB123667
Sites in Charlotte, Winston-Salem +46 more locations
Sponsor: Incyte Corporation
Sex: Female·Age: 18+
Code: NCT07214779·Phase 3·Recruiting·Listed Oct 2025
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
for HER2-positive Breast Cancer
Sites in Charlotte +28 more locations
Sponsor: Jazz Pharmaceuticals
Sex: All·Age: 18+
Code: NCT07102381·Phase 2·Recruiting·Listed Aug 2025
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
for Breast Neoplasms
Drug: Pumitamig
Sites in Charlotte +63 more locations
Sponsor: BioNTech SE
Sex: All·Age: 18+
Code: NCT07173751·Phase 3·Recruiting·Listed Sep 2025
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
for Breast Neoplasms
Sites in Charlotte, Winston-Salem +32 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT07060807·Phase 3·Recruiting·Listed Jul 2025
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
for Breast Neoplasms
Sites in Charlotte +40 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06312176·Phase 3·Recruiting·Listed Mar 2024
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
for Epithelial Ovarian Cancer
Sites in Charlotte, Winston-Salem +65 more locations
Sponsor: AbbVie
Sex: Female·Age: 18+
Code: NCT06890338·Phase 2·Recruiting·Listed Mar 2025
Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)
for Platinum-resistant Ovarian Cancer
Drug: Bevacizumab
Sites in Charlotte, Winston-Salem +31 more locations
Sponsor: Genelux Corporation
Sex: Female·Age: 18+
Code: NCT05281471·Phase 3·Recruiting·Listed Mar 2022
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
for Breast Cancer
Drug: Palazestrant
Sites in Charlotte +32 more locations
Sponsor: Olema Pharmaceuticals, Inc.
Sex: All·Age: 18+
Code: NCT07085767·Phase 3·Recruiting·Listed Jul 2025
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
for Breast Cancer
Sites in Charlotte, Winston-Salem +51 more locations
Sponsor: Exact Sciences Corporation
Sex: All·Age: 18+
Code: NCT06401421·Recruiting·Listed May 2024
A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.
for PROC
Sites in Charlotte +11 more locations
Sponsor: Whitehawk Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT07470853·Phase 1·Recruiting·Listed Mar 2026
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
for Breast Cancer
Drug: Giredestrant
Sites in Charlotte +25 more locations
Sponsor: Genentech, Inc.
Sex: All·Age: 18+
Code: NCT07100106·Phase 1, Phase 2·Recruiting·Listed Aug 2025
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
for Breast Cancer
Sites in Charlotte, Durham +13 more locations
Sponsor: Incyclix Bio
Sex: All·Age: 18+
Code: NCT05735080·Phase 1, Phase 2·Recruiting·Listed Feb 2023
A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer
for Ovarian Cancer
Sites in Charlotte +12 more locations
Sponsor: Compugen Ltd
Sex: Female·Age: 18+
Code: NCT06888921·Phase 1, Phase 2·Recruiting·Listed Mar 2025
Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer
for Metastatic Breast Cancer
Drug: Palazestrant
Sites in Charlotte +13 more locations
Sponsor: Olema Pharmaceuticals, Inc.
Sex: All·Age: 18+
Code: NCT05508906·Phase 1·Recruiting·Listed Aug 2022
Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer
for Endometrial Cancer
Sites in Charlotte +8 more locations
Sponsor: Aadi Bioscience, Inc.
Sex: All·Age: 18+
Code: NCT05997017·Phase 2·Recruiting·Listed Aug 2023
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Charlotte, Matthews +1098 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
E-Mindfulness Approaches for Living After Breast Cancer
for Breast Cancer
Sites in Charlotte, Matthews +372 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18 - 50
Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024
A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer
for Cervical Cancer
Sites in Charlotte, Statesville +115 more locations
Sponsor: GOG Foundation
Sex: Female·Age: 18+
Code: NCT04831580·Recruiting·Listed Apr 2021
WATD and Cancer-Related Fatigue: A Study For Patients Undergoing Anti-Cancer Treatment
for Pancreatic Cancer
1 location in Charlotte
Sponsor: Wake Forest University Health Sciences
Sex: All·Age: 18+
Code: NCT06291324·Recruiting·Listed Mar 2024
Utility of a Mobile Application for Young Women With Breast Cancer
for Breast Cancer
1 location in Charlotte
Sponsor: Wake Forest University Health Sciences
Sex: Female·Age: 18 - 45
Code: NCT07009093·Recruiting·Listed Jun 2025
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
for Breast Carcinoma
Sites in Charlotte, Matthews +462 more locations
Sponsor: Wake Forest University Health Sciences
Sex: All·Age: 18+
Code: NCT06418204·Recruiting·Listed May 2024
LATe Cerclage in High-risk Pregnancies (LATCH)
for Premature Birth
Sites in Charlotte +1 more location
Sponsor: Thomas Jefferson University
Sex: Female·Age: 18 - 50·Accepts healthy volunteers
Code: NCT06036446·Recruiting·Listed Sep 2023
Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy
for Estrogen Receptor Negative
Sites in Charlotte +5 more locations
Sponsor: M.D. Anderson Cancer Center
Sex: Female·Age: 30+
Code: NCT02945579·Recruiting·Listed Oct 2016
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
for Endometrial Cancer
Drug: Rilvegostomig
Sites in Charlotte, Winston-Salem +46 more locations
Sponsor: AstraZeneca
Sex: Female·Age: 18+
Code: NCT06989112·Phase 3·Recruiting·Listed May 2025
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
for Breast Cancer
Sites in Charlotte +9 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT05123482·Phase 1, Phase 2·Recruiting·Listed Nov 2021
A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study
for Ovarian Neoplasms
Drug: Niraparib
Sites in Charlotte +8 more locations
Sponsor: GlaxoSmithKline
Sex: All·Age: 18+
Code: NCT04641247·Phase 2·Recruiting·Listed Nov 2020
Top Research Study Locations in Charlotte
Researchers run research studies in Charlotte, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Levine Cancer Institute | Multiple Myeloma, Cancer, Breast Cancer | 58 |
| Carolinas Medical Center/Levine Cancer Institute | Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, B Acute Lymphoblastic Leukemia | 50 |
| Atrium Health | Aortic Dissection, Crohn Disease, Acute Cerebrovascular Disease | 28 |
| Novant Health Presbyterian Medical Center | Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, Anatomic Stage II Breast Cancer AJCC v8 | 25 |
| Atrium Health University City/LCI-University | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 16 |
| Atrium Health Pineville/LCI-Pineville | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 15 |
| Atrium Health Carolinas Medical Center | Osteomyelitis Tibia, Tibial Fractures, Articular Fractures | 12 |
| Levine Cancer Institute-Ballantyne | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 12 |
| Levine Cancer Institute-SouthPark | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 11 |
| Atrium Health Levine Cancer | Adolescent Cancer, Breast Cancer, CART Therapy | 10 |
| Atrium Health Levine Cancer Institute | Breast Cancer, Carcinoma, Squamous Cell, ER-positive Breast Cancer | 9 |
| Carolinas Medical Center | Acute Cerebrovascular Disease, Anaplastic Lymphoma Kinase-positive, Cardiovascular Diseases | 9 |
| Levine Children's Hospital | Neuroblastoma, Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL) | 9 |
| GSK Investigational Site | Breast Neoplasms, Chickenpox, HIV Infections | 7 |
| OrthoCarolina Research Institute | Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Adolescent Idiopathic Scoliosis (AIS), Advanced Rheumatoid Arthritis | 7 |
| Joint and Muscle Research Institute | Arthritis, Psoriatic, Lupus Erythematosus, Systemic, Lupus Nephritis | 6 |
| Novant Health Cancer Institute | Acute Myeloid Leukemia, in Relapse, MDS (Myelodysplastic Syndrome), Acute Myeloid Leukemia Refractory | 6 |
| OrthoCarolina | Chronic Osteomyelitis, Degenerative Disc Disease, Diabetic Foot Osteomyelitis | 6 |
| DJL Clinical Research, PLLC | Systemic Lupus Erythematosus (SLE), Hidradenitis Suppurativa, Lupus Erythematosus, Systemic | 5 |
| Atrium Health Levine Children's Hospital | Delivery Room Resuscitation, Fabry Disease, Glomerulosclerosis, Focal Segmental | 4 |
| DelRicht Research | Bipolar Depression, Bipolar Disorder, Bipolar I Disorder | 4 |
| Levine Cancer Center | Advanced Solid Tumors Cancer, B Cell Lymphoma, B-Cell Non-Hodgkin's Lymphoma | 4 |
| New Hope Clinical Research | Major Depressive Disorder, Agitation, Alzheimer Disease | 4 |
| Novant Health | AV Block, CLL/SLL, Heart Failure | 4 |
| Novant Health Presbyterian Hemby Children's Hospital | Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Mixed Phenotype Acute Leukemia | 4 |
Active & Upcoming Studies in Charlotte (2026)
Recruiting trials in Charlotte grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (181 active studies)
- Tisotumab Vedotin in Squamous Cell Carcinoma of the Vulva · Phase 2 · GOG Foundation
- Signatera Assessment in Early-Stage Endometrial Cancer · Natera, Inc.
Neurology & pain (31 active studies)
- A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine · Salvia BioElectronics
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Cardiovascular (24 active studies)
Diabetes & metabolic (14 active studies)
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities · Phase 3 · Ascletis Pharma (China) Co., Limited
Pediatric (10 active studies)
- Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients · Wake Forest University Health Sciences
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
Mental health & behavior (7 active studies)
- ALTO-207 in Adults With Treatment-resistant Depression (TRD) · Phase 2 · Alto Neuroscience
- A Novel Dialectical Behavior Therapy Brief Group Intervention for Cigarette Smoking by Patients With Cancer: An Open Clinical Trial · Wake Forest University Health Sciences
HIV / STI (5 active studies)
- Leveraging Chatbot to Improve PrEP in the Southern United States · Yale University
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · ViiV Healthcare
Vaccines (2 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) · Phase 3 · Merck Sharp & Dohme LLC
Common conditions studied in Charlotte
- Multiple Myeloma (15 active studies)
- Breast Cancer (11 active studies)
- Acute Myeloid Leukemia (10 active studies)
- Heart Failure (8 active studies)
- Obesity (7 active studies)
- Sickle Cell Disease (7 active studies)
Leading research sponsors in Charlotte
- Wake Forest University Health Sciences
- National Cancer Institute (NCI)
- AstraZeneca
- Janssen Research & Development, LLC
- AbbVie
Frequently asked questions
How many paid clinical trials are currently recruiting in Charlotte?
There are approximately 513 recruiting clinical trials in Charlotte, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Charlotte pay participants?
Most recruiting trials in Charlotte compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Charlotte?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Charlotte?
The most common conditions under active study in Charlotte include Multiple Myeloma (15), Breast Cancer (11), Acute Myeloid Leukemia (10), Heart Failure (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Charlotte?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Charlotte on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Charlotte?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Charlotte?
Recruiting research sites in Charlotte include Levine Cancer Institute, Carolinas Medical Center/Levine Cancer Institute, Atrium Health, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Charlotte right now?
The largest active categories in Charlotte are Cancer & tumors (181), Neurology & pain (31), Cardiovascular (24). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
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