Paid Clinical Trials in Charlotte, NC
As of June 2026, 561 paid clinical trials are recruiting in Charlotte, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Charlotte offers studies at sites including Levine Cancer Institute for conditions such as Multiple Myeloma, Acute Myeloid Leukemia, Breast Cancer, Heart Failure. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Charlotte
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Charlotte has approximately 561 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.
Top Research Study Locations in Charlotte
Researchers run research studies in Charlotte, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Levine Cancer Institute | Multiple Myeloma, Cancer, Breast Cancer | 58 |
| Carolinas Medical Center/Levine Cancer Institute | Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, B Acute Lymphoblastic Leukemia | 56 |
| Atrium Health | Aortic Dissection, Crohn Disease, Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands | 33 |
| Novant Health Presbyterian Medical Center | Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, Anatomic Stage I Breast Cancer AJCC v8 | 30 |
| Atrium Health Pineville/LCI-Pineville | Extensive Stage Lung Small Cell Carcinoma, Advanced Extrapulmonary Neuroendocrine Carcinoma, Anatomic Stage I Breast Cancer AJCC v8 | 19 |
| Atrium Health University City/LCI-University | Extensive Stage Lung Small Cell Carcinoma, Advanced Extrapulmonary Neuroendocrine Carcinoma, Anatomic Stage I Breast Cancer AJCC v8 | 18 |
| Levine Children's Hospital | Neuroblastoma, Pediatric Cancer, Acute Lymphoblastic Leukemia (ALL) | 13 |
| Atrium Health Carolinas Medical Center | Osteomyelitis Tibia, Tibial Fractures, Articular Fractures | 12 |
| Carolinas Medical Center | Acute Cerebrovascular Disease, Anaplastic Lymphoma Kinase-positive, Atrial Fibrillation | 12 |
| Levine Cancer Institute-Ballantyne | Advanced Extrapulmonary Neuroendocrine Carcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 11 |
| Levine Cancer Institute-SouthPark | Advanced Extrapulmonary Neuroendocrine Carcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 11 |
| Atrium Health Levine Cancer | Cancer, Adolescent Cancer, Breast Cancer | 9 |
| Atrium Health Levine Cancer Institute | Breast Cancer, Carcinoma, Squamous Cell, ER-positive Breast Cancer | 9 |
| OrthoCarolina Research Institute | Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Adolescent Idiopathic Scoliosis (AIS), Advanced Rheumatoid Arthritis | 8 |
| GSK Investigational Site | Breast Neoplasms, Chickenpox, HIV Infections | 6 |
| Joint and Muscle Research Institute | Arthritis, Psoriatic, Lupus Erythematosus, Systemic, Lupus Nephritis | 6 |
| Levine Cancer Center | Advanced Solid Tumors Cancer, B Cell Lymphoma, B-Cell Non-Hodgkin's Lymphoma | 6 |
| OrthoCarolina | Chronic Osteomyelitis, Degenerative Disc Disease, Diabetic Foot Osteomyelitis | 6 |
| Atrium Health Levine Children's Hospital | Alport Syndrome, Delivery Room Resuscitation, Fabry Disease | 5 |
| DJL Clinical Research, PLLC | Systemic Lupus Erythematosus (SLE), Hidradenitis Suppurativa, Lupus Erythematosus, Systemic | 5 |
| New Hope Clinical Research | Major Depressive Disorder, Agitation, Alzheimer Disease | 5 |
| OnSite Clinical Solutions | Focal Epilepsy, Alopecia, Areata Alopecia | 5 |
| Oncology Specialists of Charlotte | CRC (Colorectal Cancer), Carcinoma, Transitional Cell, Childhood Extracranial Germ Cell Tumor | 5 |
| OrthoCarolina Research Institute, Inc. | Avascular Necrosis, Avascular Necrosis of the Talus, Continuous Local Infiltration Analgesia | 5 |
| DelRicht Research | Bipolar Depression, Bipolar Disorder, Bipolar I Disorder | 4 |
Active & Upcoming Studies in Charlotte (2026)
Recruiting trials in Charlotte grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (196 active studies)
- A Phase I Study of LP-118 In Combination With Ponatinib, Dexamethasone And Blinatumomab For Adults With Newly-Diagnosed, BCR::ABL1-Positive ALL · Phase 1 · Wake Forest University Health Sciences
- Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients · Wake Forest University Health Sciences
Neurology & pain (34 active studies)
- Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up · Epiminder America, Inc.
- Prophylactic TBR on Phantom Limb Pain · OrthoCarolina Research Institute, Inc.
Cardiovascular (26 active studies)
Pediatric (13 active studies)
- Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients · Wake Forest University Health Sciences
- Comprehensive Care for AYA: Needs Assessment Survey · Wake Forest University Health Sciences
Mental health & behavior (11 active studies)
- ALTO-207 in Adults With Treatment-resistant Depression (TRD) · Phase 2 · Alto Neuroscience
- A Novel Dialectical Behavior Therapy Brief Group Intervention for Cigarette Smoking by Patients With Cancer: An Open Clinical Trial · Wake Forest University Health Sciences
Diabetes & metabolic (10 active studies)
HIV / STI (5 active studies)
- Leveraging Chatbot to Improve PrEP in the Southern United States · Yale University
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · ViiV Healthcare
Vaccines (2 active studies)
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) · Phase 3 · Merck Sharp & Dohme LLC
Eye & vision (2 active studies)
- A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DME · Phase 3 · Hoffmann-La Roche
- Extension Study for the Port Delivery System With Ranibizumab (Portal) · Phase 3 · Hoffmann-La Roche
Common conditions studied in Charlotte
- Multiple Myeloma (17 active studies). Recruiting Multiple Myeloma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Acute Myeloid Leukemia (10 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Breast Cancer (9 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (8 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Cancer (7 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Neuroblastoma (7 active studies). Recruiting Neuroblastoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Charlotte
- Wake Forest University Health Sciences
- National Cancer Institute (NCI)
- AstraZeneca
- Janssen Research & Development, LLC
- AbbVie
Local regulations and guidelines
Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Charlotte. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Charlotte
Hipa.ai aggregates every recruiting study in Charlotte from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Charlotte?
There are approximately 561 recruiting clinical trials in Charlotte, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Charlotte pay participants?
Most recruiting trials in Charlotte compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Charlotte?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Charlotte?
The most common conditions under active study in Charlotte include Multiple Myeloma (17), Acute Myeloid Leukemia (10), Breast Cancer (9), Heart Failure (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Charlotte?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Charlotte on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Charlotte?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Charlotte?
Recruiting research sites in Charlotte include Levine Cancer Institute, Carolinas Medical Center/Levine Cancer Institute, Atrium Health, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Charlotte right now?
The largest active categories in Charlotte are Cancer & tumors (196), Neurology & pain (34), Cardiovascular (26). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.