Non-small cell lung cancer (NSCLC) Clinical Trials in Los Angeles, CA
As of July 2026, 59 paid clinical trials are recruiting for Non-small cell lung cancer (NSCLC) in Los Angeles, California. Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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60 clinical trials for Non-small cell lung cancer (NSCLC)
·Clear filters·↓ Download CSVA Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
GEMINI-NSCLC: NSCLC Biomarker Study
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)
A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors
Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations
A Study of NX-1607 in Adults With Advanced Malignancies
A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors
A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
A Study of VET3-TGI in Patients With Solid Tumors
Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.
A Study of MGC026 in Participants With Advanced Solid Tumors
About research studies in Los Angeles
Los Angeles has approximately 1,973 recruiting research studies across a wide range of therapeutic areas. California hosts a dense network of world-class research institutions, including UC San Diego Health, Stanford Medicine, UCLA Health, UCSF, City of Hope, and Scripps Research. The state's thriving biotech corridor and diverse patient population make it a national hub for both early-phase and late-phase clinical research.
Top Research Study Locations in Los Angeles
Researchers run research studies in Los Angeles, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Cedars-Sinai Medical Center | Acute Myeloid Leukemia, Breast Cancer, Stage IV Lung Cancer AJCC v8 | 227 |
| Children's Hospital Los Angeles | Neuroblastoma, Acute Myeloid Leukemia, Anesthesia | 133 |
| University of California, Los Angeles | Alzheimer Disease, Depression, Focal Epilepsy | 110 |
| University of Southern California | Acute Pancreatitis, Amyotrophic Lateral Sclerosis, Breast Cancer | 93 |
| Cedars Sinai Medical Center | Anxiety, Crohn's Disease, Heart Failure | 68 |
| UCLA / Jonsson Comprehensive Cancer Center | Prostate Carcinoma, Prostate Adenocarcinoma, Stage II Prostate Cancer AJCC v8 | 68 |
| USC / Norris Comprehensive Cancer Center | Malignant Solid Neoplasm, Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8 | 65 |
| University of California Los Angeles | Parkinson Disease, Bladder Cancer, Breast Cancer | 65 |
| UCLA | Bladder Cancer, Colorectal Cancer, Type2diabetes | 53 |
| USC Norris Comprehensive Cancer Center | Colorectal Cancer, Endometrial Cancer, NSCLC | 53 |
| Los Angeles General Medical Center | Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma | 52 |
| Kaiser Permanente Los Angeles Medical Center | Anatomic Stage IV Breast Cancer AJCC v8, Intracerebral Hemorrhage, Ischemic Stroke | 43 |
| Children's Hospital of Los Angeles | Acute Lymphoblastic Leukemia, Cystic Fibrosis, Von Willebrand Disease (VWD) | 36 |
| Valkyrie Clinical Trials | Multiple Myeloma, Solid Tumors, Breast Cancer | 33 |
| Ronald Reagan UCLA Medical Center | Ischemic Stroke, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma | 26 |
| USC/Norris Comprehensive Cancer Center | Breast Neoplasms, Bladder Cancer, Breast Cancer | 21 |
| UCLA Medical Center | Colorectal Cancer, CRC, Cancer | 20 |
| Kaiser Permanente West Los Angeles | Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer, Adenocarcinoma of the Colon | 17 |
| GSK Investigational Site | Gastrointestinal Neoplasms, Non-alcoholic Fatty Liver Disease, Breast Neoplasms | 14 |
| David Geffen School of Medicine at UCLA | Developmental and Epileptic Encephalopathy, Candidemia, Candidiasis, Invasive | 14 |
| Keck Hospital of USC | Advanced Hepatocellular Carcinoma, Advanced or Metastatic Solid Tumors, Airway Disease | 13 |
| Keck Medicine of USC Koreatown | Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma | 13 |
| University of California at Los Angeles | ASD, Advanced Tumors, Alzheimer's Disease | 13 |
| Cedars Sinai | 1st Line NSCLC, Advanced Solid Tumor, Aortic Valve Disease Mixed | 12 |
| UCLA Health | Adult Growth Hormone Deficiency, Cancer, Cutaneous Melanoma | 12 |
Active & Upcoming Studies in Los Angeles (2026)
Recruiting trials in Los Angeles grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (631 active studies)
- Zipalertinib With Carboplatin and Pemetrexed for the Treatment of Resectable, Stage II-IIIB, Non-Small Cell Lung Cancer · Phase 2 · Jonsson Comprehensive Cancer Center
- A Disposable Negative Pressure Wound Therapy Device (SNaP) to Promote Wound Healing in the Lower Limbs Following Mohs Micrographic Surgery for Non-melanoma Skin Cancer · Jonsson Comprehensive Cancer Center
Neurology & pain (117 active studies)
- Morphine or Ketamine for Analgesia · Phase 3 · Columbia University
- Measuring Pelvic Floor Muscle Fitness Before and After Treatment · University of California, Los Angeles
Cardiovascular (91 active studies)
- Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress · Duke University
- PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis · Phase 3 · Duke University
Diabetes & metabolic (62 active studies)
- Screening For Social Determinants Of Health In Routine Diabetes Care · University of California, Los Angeles
- Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or Obese · Phase 2 · Biomed Industries, Inc.
Mental health & behavior (61 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- Group PACBT for Depression · Phase 2 · University of California, Los Angeles
Pediatric (32 active studies)
- Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). · Phase 2 · BrainChild Bio, Inc
- Early Re-Initiation of Semaglutide Post Sleeve Gastrectomy in Youth · Phase 3 · Children's Hospital Los Angeles
HIV / STI (25 active studies)
- Evaluating a Clinical Decision Support Tool for Antiretroviral Therapy Optimization · Keck School of Medicine of USC
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
Eye & vision (12 active studies)
- Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension · Stanford University
- This Clinical Trial Compares Two Phacoemulsification Systems Used in a Bilateral Cataract Surgery Subjects in Order to Study CDE and Ultrasound Time During Cataract Removal · Nicole Fram M.D.
Vaccines (10 active studies)
Common conditions studied in Los Angeles
- Breast Cancer (42 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Colorectal Cancer (30 active studies). Colorectal cancer trials explore novel chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors.
- Prostate Cancer (26 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
- Ovarian Cancer (22 active studies). Ovarian cancer research examines PARP inhibitors, maintenance therapies, and antibody-drug conjugates for recurrent and platinum-resistant disease.
- Cancer (21 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Heart Failure (20 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
Leading research sponsors in Los Angeles
- University of California, Los Angeles
- University of Southern California
- Cedars-Sinai Medical Center
- Jonsson Comprehensive Cancer Center
- National Cancer Institute (NCI)
Local regulations and guidelines
Clinical trials in California are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. In addition, California-specific protections such as the California Consumer Privacy Act (CCPA) and the Confidentiality of Medical Information Act (CMIA) impose stringent data-privacy requirements on research involving California residents.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Los Angeles. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Los Angeles
Hipa.ai aggregates every recruiting study in Los Angeles from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Los Angeles?
There are approximately 1,973 recruiting clinical trials in Los Angeles, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Los Angeles pay participants?
Most recruiting trials in Los Angeles compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Los Angeles?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Los Angeles?
The most common conditions under active study in Los Angeles include Breast Cancer (42), Colorectal Cancer (30), Prostate Cancer (26), Ovarian Cancer (22), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Los Angeles?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Los Angeles on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Los Angeles?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Los Angeles?
Recruiting research sites in Los Angeles include Cedars-Sinai Medical Center, Children's Hospital Los Angeles, University of California, Los Angeles, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Los Angeles right now?
The largest active categories in Los Angeles are Cancer & tumors (631), Neurology & pain (117), Cardiovascular (91). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.