Oncology Clinical Trials in Chapel Hill, NC
As of August 2026, 164 paid clinical trials are recruiting for Oncology in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Chapel Hill
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
165 clinical trials for Oncology
·Clear filters·A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma
A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)
GEMINI-NSCLC: NSCLC Biomarker Study
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer
A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
A Study of 177Lu-FAP-2286 in Advanced Solid Tumors
PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
Tempus Small Cell Lung Cancer Observational Study (Sculptor)
A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments
Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
A Study of YL201 in Patients With Advanced Solid Tumors
Top Research Study Locations in Chapel Hill
Researchers run research studies in Chapel Hill, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of North Carolina at Chapel Hill | Cancer, ARDS, ARDS (Acute Respiratory Distress Syndrome) | 145 |
| University of North Carolina | Breast Cancer, Metastatic Breast Cancer, Ulcerative Colitis | 96 |
| UNC Lineberger Comprehensive Cancer Center | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, B Acute Lymphoblastic Leukemia | 87 |
| The University of North Carolina at Chapel Hill | Hypertension, ACL Tear, AML | 16 |
| UNC Chapel Hill | Lupus Nephritis, Lymphatic Malformations, Barrett's Esophagus | 16 |
| Lineberger Comprehensive Cancer Center | Endometrial Cancer, Adolescent and Young Adult With Brain Cancer, Advanced Solid Tumors | 13 |
| University of North Carolina Chapel Hill | Alport Syndrome, Articular Fractures, Asthma (Diagnosis) | 13 |
| University of North Carolina, Chapel Hill | Hearing Loss, Sensorineural, Acute Myeloid Leukemia (AML), Aging | 11 |
| University of North Carolina Medical Center | Breast Neoplasms, Neoplasm Metastasis, Atrial Fibrillation | 10 |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Cachexia, Melanoma, Cutaneous Malignant, Metastatic Melanoma | 9 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Breast Cancer, Chronic Myeloproliferative Disorders, Leukemia | 8 |
| University of North Carolina - Chapel Hill | Obstetrical Complications, Ann Arbor Stage I Diffuse Large B-Cell Lymphoma, Ann Arbor Stage II Diffuse Large B-Cell Lymphoma | 8 |
| University of North Carolina at Chapel Hill, Department of Radiation Oncology | Head and Neck Cancer, Sarcoma, Brain Metastases | 7 |
| UNC Hospitals | Acute Respiratory Failure, Comparative Effectiveness, Critical Illness | 6 |
| Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill | Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II | 5 |
| University of North Carolina At Chapel Hill | Chronic Lymphocytic Leukemia, Myeloproliferative Neoplasms, Small Lymphocytic Lymphoma | 5 |
| The University of North Carolina | Breast Cancer, Breast Neoplasms, Kidney Neoplasms | 4 |
| UNC Hospitals, University of North Carolina at Chapel Hill | Acute Myeloid Leukemia, Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With KMT2A Rearrangement | 4 |
| Univeristy of North Carolina at Chapel Hill | Cystic Fibrosis, Drug Induced Liver Injury, Endometrial Cancer | 4 |
| University of North Carolina Hospitals | Carotid Artery Calcification, Carotid Artery Diseases, Gastroschisis | 4 |
| University of North Carolina School of Medicine | Barrett Esophagus, Barretts Esophagus With Dysplasia, Brain Injury | 4 |
| Clinical Trial Site | AQP4+ NMOSD, Generalized Myasthenia Gravis, Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | 3 |
| North Carolina Children's Hospital: Department of Pediatrics, Division of Allergy, Immunology and Rheumatology | Allergy, Alpha-Gal Syndrome, Peanut Allergy | 3 |
| UNC | Acute Kidney Injury, Chronic Kidney Disease(CKD), Epidemiology | 3 |
| UNC Center for Health Promotion and Disease Prevention | Child Obesity, Down Syndrome, Obesity | 3 |
Active & Upcoming Studies in Chapel Hill (2026)
Recruiting trials in Chapel Hill grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (241 active studies)
- Improving Affordability in Cancer Care Through Economic Screening and Support (I-ACCESS) · UNC Lineberger Comprehensive Cancer Center
- A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma · Phase 3 · AbbVie
Diabetes & metabolic (38 active studies)
- Optimization of Dietary Adherence in a Mobile Weight Loss Intervention · UNC Lineberger Comprehensive Cancer Center
- Treating Binge Eating and Obesity Digitally in Women · University of North Carolina, Chapel Hill
Cardiovascular (28 active studies)
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF · Phase 3 · AstraZeneca
- Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial · Phase 3 · The George Washington University Biostatistics Center
Neurology & pain (19 active studies)
- Early Dental Risk Screening for Pediatric Sleep-Disordered Breathing · University of North Carolina, Chapel Hill
- Neural Mechanisms of Light Driven Analgesia · University of North Carolina, Chapel Hill
Pediatric (16 active studies)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
- Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement · University of North Carolina, Chapel Hill
Mental health & behavior (13 active studies)
- Teen Vulnerability to Irritability: Brain and Estrogen Changes · Phase 4 · University of North Carolina, Chapel Hill
- Testing STAR and TextSTAR: A Randomized Controlled Trial · University of Wisconsin, Madison
HIV / STI (10 active studies)
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Characterization of Doxycycline Pharmacokinetics and Adherence · Phase 1 · HIV Prevention Trials Network
Vaccines (4 active studies)
- Woodsmoke Exposure, Influenza Infection, and Nasal Immunity · Phase 4 · University of North Carolina, Chapel Hill
- Long-Term Study of COVID-19 Infection and Long COVID · University of North Carolina, Chapel Hill
Eye & vision (1 active study)
- Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial · University of Pennsylvania
Common conditions studied in Chapel Hill
- Breast Cancer (27 active studies)
- Cancer (16 active studies)
- Multiple Myeloma (16 active studies)
- Obesity (11 active studies)
- Ulcerative Colitis (10 active studies)
- Chronic Lymphocytic Leukemia (9 active studies)
Leading research sponsors in Chapel Hill
- University of North Carolina, Chapel Hill
- UNC Lineberger Comprehensive Cancer Center
- National Cancer Institute (NCI)
- Children's Oncology Group
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Chapel Hill?
There are approximately 692 recruiting clinical trials in Chapel Hill, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Chapel Hill pay participants?
Most recruiting trials in Chapel Hill compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Chapel Hill?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Chapel Hill?
The most common conditions under active study in Chapel Hill include Breast Cancer (27), Cancer (16), Multiple Myeloma (16), Obesity (11), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Chapel Hill?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chapel Hill on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Chapel Hill?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Chapel Hill?
Recruiting research sites in Chapel Hill include University of North Carolina at Chapel Hill, University of North Carolina, UNC Lineberger Comprehensive Cancer Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Chapel Hill right now?
The largest active categories in Chapel Hill are Cancer & tumors (241), Diabetes & metabolic (38), Cardiovascular (28). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.