As of June 2026, 1 paid clinical trial is recruiting for COVID-19 / long COVID in Chapel Hill, North Carolina. COVID-19 research evaluates next-generation vaccines, antivirals, and therapies for long COVID. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Chapel Hill has approximately 726 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.
Researchers run research studies in Chapel Hill, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of North Carolina at Chapel Hill | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 147 |
| University of North Carolina | Breast Cancer, Metastatic Breast Cancer, Ulcerative Colitis | 100 |
| UNC Lineberger Comprehensive Cancer Center | Breast Cancer, Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8 | 92 |
| The University of North Carolina at Chapel Hill | Hypertension, ACL Tear, Aortic Stenosis | 19 |
| UNC Chapel Hill | Lupus Nephritis, Barrett's Esophagus, CLOVES Syndrome | 15 |
| Lineberger Comprehensive Cancer Center | Endometrial Cancer, Adolescent and Young Adult With Brain Cancer, Advanced Solid Tumors | 13 |
| University of North Carolina Chapel Hill | Alport Syndrome, Articular Fractures, Asthma (Diagnosis) | 13 |
| University of North Carolina Medical Center | Breast Neoplasms, Neoplasm Metastasis, Atrial Fibrillation | 12 |
| University of North Carolina, Chapel Hill | Hearing Loss, Sensorineural, Acute Myeloid Leukemia (AML), Aging | 10 |
| University of North Carolina - Chapel Hill | Obstetrical Complications, Ann Arbor Stage I Diffuse Large B-Cell Lymphoma, Ann Arbor Stage II Diffuse Large B-Cell Lymphoma | 9 |
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Breast Cancer, Chronic Myeloproliferative Disorders, Leukemia | 8 |
| UNC Hospitals | Comparative Effectiveness, Family Engagement, Health Care | 8 |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Cachexia, Melanoma, Cutaneous Malignant, Metastatic Melanoma | 7 |
| University of North Carolina at Chapel Hill, Department of Radiation Oncology | Sarcoma, Brain Metastases, Cancer | 6 |
| UNC-Chapel Hill | Binge Eating, Binge-Eating Disorder, Focal Epilepsy | 5 |
| Univeristy of North Carolina at Chapel Hill | Acute Myelogenous Leukemia, Breast Cancer, Cystic Fibrosis | 5 |
| Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill | Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II | 4 |
| The University of North Carolina | Breast Cancer, Breast Neoplasms, Kidney Neoplasms | 4 |
| University of North Carolina Hospitals | Gastroschisis, Leukemia, Obesity | 4 |
| University of North Carolina School of Medicine | Barrett Esophagus, Barretts Esophagus With Dysplasia, Brain Injury | 4 |
| Carolina Center for Neurostimulation | Major Depressive Disorder, Antenatal Depression, Depression | 3 |
| Chapel Hill CRS | HIV-1-infection, HIV, Major Depressive Disorder | 3 |
| Clinical Trial Site | AQP4+ NMOSD, Generalized Myasthenia Gravis, Hereditary Hemorrhagic Telangiectasia | 3 |
| North Carolina Children's Hospital: Department of Pediatrics, Division of Allergy, Immunology and Rheumatology | Allergy, Alpha-Gal Syndrome, Peanut Allergy | 3 |
| UNC Center for Health Promotion and Disease Prevention | Child Obesity, Down Syndrome, Obesity | 3 |
Recruiting trials in Chapel Hill grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Hipa.ai aggregates every recruiting study in Chapel Hill from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
There are approximately 726 recruiting clinical trials in Chapel Hill, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Chapel Hill compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Chapel Hill include Breast Cancer (31), Multiple Myeloma (17), Cancer (15), Obesity (11), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chapel Hill on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Chapel Hill include University of North Carolina at Chapel Hill, University of North Carolina, UNC Lineberger Comprehensive Cancer Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Chapel Hill are Cancer & tumors (243), Diabetes & metabolic (42), Cardiovascular (29). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.