As of July 2026, 33 paid clinical trials are recruiting for GI oncology in Durham, North Carolina. GI oncology trials cover colorectal, pancreatic, gastric, esophageal, liver, and biliary cancers — testing chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Durham has approximately 1,090 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.
Researchers run research studies in Durham, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Duke University Medical Center | Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Interstitial Lung Disease | 301 |
| Duke University | Heart Failure, Prostate Cancer, Amyotrophic Lateral Sclerosis | 201 |
| Duke University Hospital | Heart Failure, Stroke, Traumatic Brain Injury | 57 |
| Duke University Health System | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, WHO Grade III Glioma | 48 |
| Duke Cancer Institute | Breast Cancer, Advanced Solid Tumor, Cancer | 41 |
| Duke Cancer Center | Advanced Solid Tumor, Breast Cancer, Non-small Cell Lung Cancer | 32 |
| Durham VA Medical Center, Durham, NC | Cancer, Hearing Loss, Metastatic Prostate Cancer | 30 |
| Durham VA Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 19 |
| Duke University School of Medicine | Accidental Falls/Prevention and Control, Acquired Resistance to KRAS G12C Inhibitor, Acute Respiratory Failure | 14 |
| Duke University Eye Center | Amblyopia, Retinal Disease, Eye Diseases | 12 |
| Duke Eye Center | Geographic Atrophy, Stargardt Disease, Age-Related Macular Degeneration | 11 |
| Duke | Acute GVHD, Acute Myelogenous Leukemia, Advanced Ovarian Carcinoma | 8 |
| Clinical Trial Site | ATTR Amyloidosis, Cerebral Amyloid Angiopathy, Cutaneous Sarcoidosis | 7 |
| Duke Children's Hospital | Adamantinomatous Craniopharyngioma, Becker Muscular Dystrophy, Cardiomyopathy | 7 |
| Duke Health | Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias, Breast Reconstruction | 7 |
| RTI International | Alcohol Misuse, Infant, Low Birth Weight, Infant, Newborn | 7 |
| Duke University - Main Hospital and Clinics | COVID-19 Infection, Gram-negative Bacterial Infection, Healthy | 5 |
| Duke Vaccine and Trials Unit | COVID-19 Infection, Clostridioides Difficile Associated Disease, Healthy | 5 |
| Duke University Medical Center - Duke Cancer Center | Cancer of the Prostate, Colorectal Cancer, Hormone Sensitive Prostate Cancer | 5 |
| GSK Investigational Site | Gastrointestinal Neoplasms, Colonic Neoplasms, Lung Diseases, Interstitial | 5 |
| Duke Cancer Network | Advanced Breast Cancer, Advanced Colorectal Adenocarcinoma, Advanced Colorectal Carcinoma | 4 |
| Duke Children's Hospital & Health Center | Analgesics, Opioid, Congenital Heart Disease (CHD), Dravet Syndrome | 4 |
| Duke Clinical Research Institute | Acute Pain, Lupus Erythematosus, Systemic, Lupus Nephritis | 4 |
| Duke Lung Transplant Clinic - Clinic 2F/2G - PPDS | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 4 |
| Duke Cancer Center Southpoint | Clear Cell Renal Cell Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma | 3 |
Recruiting trials in Durham grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.
Hipa.ai aggregates every recruiting study in Durham from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
There are approximately 1,090 recruiting clinical trials in Durham, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Durham compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Durham include Heart Failure (23), Breast Cancer (20), Prostate Cancer (17), Cancer (13), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Durham on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Durham include Duke University Medical Center, Duke University, Duke University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Durham are Cancer & tumors (305), Cardiovascular (101), Neurology & pain (68). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.