GI oncology Clinical Trials in Durham, NC
As of September 2026, 31 paid clinical trials are recruiting for GI oncology in Durham, North Carolina. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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31 clinical trials for GI oncology
·Clear filters·Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
A Study of PHST001 in Advanced Solid Tumors
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer
A Study of PHN-012 in Patients With Advanced Solid Tumors
Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer
A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
The Vanguard Study: Testing a New Way to Screen for Cancer
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
DESTINY-PANTUMOUR04
First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
Top Research Study Locations in Durham
Researchers run research studies in Durham, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Duke University Medical Center | Acute Myeloid Leukemia, Pulmonary Arterial Hypertension, Sickle Cell Disease | 282 |
| Duke University | Heart Failure, Prostate Cancer, Coronary Artery Disease | 202 |
| Duke University Hospital | Heart Failure, Stroke, Traumatic Brain Injury | 57 |
| Duke University Health System | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, WHO Grade III Glioma | 46 |
| Duke Cancer Institute | Breast Cancer, Advanced Solid Tumor, Cancer | 40 |
| Duke Cancer Center | Advanced Solid Tumor, Breast Cancer, Advanced Breast Cancer | 32 |
| Durham VA Medical Center, Durham, NC | Tobacco Use Disorder, Cancer, Hearing Loss | 32 |
| Durham VA Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 16 |
| Duke University School of Medicine | Accidental Falls/Prevention and Control, Acquired Resistance to KRAS G12C Inhibitor, Acute Respiratory Failure | 14 |
| Duke University Eye Center | Amblyopia, Glaucoma, Retinal Disease | 12 |
| Duke Eye Center | Geographic Atrophy, Stargardt Disease, Age - Related Macular Degeneration (AMD) | 11 |
| Duke Vaccine and Trials Unit | COVID -19, COVID-19 Infection, COVID-19 Vaccines | 7 |
| Clinical Trial Site | ATTR Amyloidosis, Breast Cancer, Cutaneous Sarcoidosis | 7 |
| Duke University Medical Center - Duke Cancer Center | Advanced Solid Tumor, Anal Squamous Cell Carcinoma, Bladder Cancer | 7 |
| GSK Investigational Site | Gastrointestinal Neoplasms, Colonic Neoplasms, HIV Infections | 7 |
| Duke University - Main Hospital and Clinics | Advanced Hepatocellular Carcinoma, COVID-19 Infection, Carcinoma, Hepatocellular | 6 |
| Duke Health | Breast Reconstruction, Cancer, Congestive Heart Failure Chronic | 6 |
| Duke | Advanced Ovarian Carcinoma, COPD (Chronic Obstructive Pulmonary Disease), Chronic Graft Versus Host Disease | 5 |
| Duke Children's Hospital | Adamantinomatous Craniopharyngioma, Becker Muscular Dystrophy, Cardiomyopathy | 5 |
| Duke Cancer Network | Advanced Breast Cancer, Advanced Colorectal Adenocarcinoma, Advanced Colorectal Carcinoma | 4 |
| Duke Children's Hospital & Health Center | Analgesics, Opioid, Congenital Heart Disease (CHD), Dravet Syndrome | 4 |
| Duke Lung Transplant Clinic - Clinic 2F/2G - PPDS | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 4 |
| RTI International | Alcohol Misuse, Bystander Intervention, Community Reintegration | 4 |
| Duke Blood Cancer Center | AML With Mutated NPM1, Acute Myeloid Leukemia, Acute Myeloid Leukemia Recurrent | 3 |
| Duke Cancer Center Southpoint | Clear Cell Renal Cell Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma | 3 |
Active & Upcoming Studies in Durham (2026)
Recruiting trials in Durham grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (292 active studies)
- Maximizing Quality of Life After Cancer Through Rehabilitation · VA Office of Research and Development
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
Cardiovascular (97 active studies)
Neurology & pain (68 active studies)
- ESP Blocks for Posterior Spinal Fusion · Phase 4 · Duke University
- Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial · Phase 2 · VA Office of Research and Development
Diabetes & metabolic (32 active studies)
- Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity · 3-C Institute for Social Development
- Studies of Insulin and Glucagon Action in the Liver · Phase 1, Phase 2 · Duke University
Pediatric (26 active studies)
- The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · Phase 2 · Wake Forest University Health Sciences
- Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children · Duke University
Mental health & behavior (22 active studies)
- Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms · VA Office of Research and Development
- Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness · VA Office of Research and Development
HIV / STI (14 active studies)
Eye & vision (11 active studies)
- Effect of Late Ripcord Removal From Glaucoma Drainage Device · Duke University
- Advancing Pediatric Retinal Imaging With Auto-aligned OCT · Duke University
Vaccines (10 active studies)
- A Safety, Reactogenicity and Immunogenicity Trial of RVX-sCPD9 Booster Intranasal COVID-19 Vaccine · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age · Phase 3 · GlaxoSmithKline
Common conditions studied in Durham
- Breast Cancer (20 active studies)
- Heart Failure (20 active studies)
- Prostate Cancer (16 active studies)
- Cancer (12 active studies)
- Acute Myeloid Leukemia (11 active studies)
- Colorectal Cancer (11 active studies)
Leading research sponsors in Durham
- Duke University
- VA Office of Research and Development
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Durham?
There are approximately 1,059 recruiting clinical trials in Durham, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Durham pay participants?
Most recruiting trials in Durham compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Durham?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Durham?
The most common conditions under active study in Durham include Breast Cancer (20), Heart Failure (20), Prostate Cancer (16), Cancer (12), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Durham?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Durham on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Durham?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Durham?
Recruiting research sites in Durham include Duke University Medical Center, Duke University, Duke University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Durham right now?
The largest active categories in Durham are Cancer & tumors (292), Cardiovascular (97), Neurology & pain (68). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.