Cognitive impairment / decline Clinical Trials

Recruiting cognitive impairment / decline studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat cognitive impairment / decline. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting cognitive impairment / decline studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting cognitive impairment / decline trials

Within

Fall Prevention in Mild Cognitive Impairment

for Cognitive Impairment

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+

Code: NCT07507812

A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia

for Schizophrenia

Sponsor: European Group for Research In Schizophrenia

Sex: All·Age: 18 - 55

Code: NCT07084831·Phase 3

The CDAC Study - Cerebral Dysfunction After Coronary Revascularization

for CABG

Sponsor: The Scripps Research Institute

Sex: All·Age: 18+

Code: NCT07491120

Minocycline In Neurocognitive Outcomes - Sickle Cell Disease

for Sickle Cell Disease

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05605366·Phase 1

Robot-Assisted Meditation for Older Adults With Cognitive Concerns

for Cognitive Impairment

Sponsor: Johns Hopkins University

Sex: All·Age: 65 - 80

Code: NCT07435220

Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals

for Cognitive Change

Sponsor: Virginia Polytechnic Institute and State University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05303428

Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study

for Aging

1 site in Galveston

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT07313540

The Care for America's Aging Study

for Cognitive Impairment

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06021704

Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue

for Long COVID

Sponsor: University of Las Palmas de Gran Canaria

Sex: All·Age: 18 - 70

Code: NCT07709234

Neurocognitive Assessment CNSL and LGG

for PCNSL

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07710131

Predictors of Cognitive Decline and Delirium in Older Women With Ovarian Cancer

for Ovarian Cancer

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: Female·Age: 70+

Code: NCT07716800

Eye Tracking for Early Identification of Post-ICU Cognitive Impairment

for Post Intensive Care Syndrome (PICS)

Sponsor: Shanghai Zhongshan Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07676864

Cognitive Function and Quality of Life in Obstructive Sleep Apnea

for Obstructive Sleep Apnea

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07678918

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

for Cannabis Use

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06351540·Phase 1

Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns

for Subjective Cognitive Decline

Sponsor: IRCCS San Raffaele

Sex: All·Age: 40+

Code: NCT07652931

Virtual Mindfulness and Breathing Training for Stress, Burnout, Sleep, and Cognition in Rotating-Shift Nurses

for Occupational Burnout

Sponsor: Chang Shih-Chin

Sex: All·Age: 20 - 65·Accepts healthy volunteers

Code: NCT07028788

Brain Functional Connectivity Mechanism of Cognitive Flexibility Impairment and rTMS Intervention in Major Depressive Disorder

for Depressive Disorder, Major

Sponsor: Second Xiangya Hospital of Central South University

Sex: All·Age: 18 - 45

Code: NCT07161492

Effects of Accelerated rTMS on Cognitive Function

for Cognitive Decline

1 site in San Francisco

Sponsor: San Francisco Neurology and Sleep Center

Sex: All·Age: 50 - 90

Code: NCT07547319

Apply to this trial

Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk

for Cognitive Impairment

Sponsor: University of Edinburgh

Sex: All·Age: 70+·Accepts healthy volunteers

Code: NCT07470216

Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum

for Schizophrenia

Sponsor: Shanghai Mental Health Center

Sex: All·Age: 15 - 45·Accepts healthy volunteers

Code: NCT07702526

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

for ME/CFS

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07523113

Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment

for Older Adults

Sponsor: Peking University First Hospital

Sex: All·Age: 60+

Code: NCT07610343·Phase 4

Feasibility and Acceptability of StimolIrpinia for Cognitive Rehabilitation After Severe Acquired Brain Injury

for Severe Acquired Brain Injury

Sponsor: Alfonso Magliacano

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07718321

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Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment

for Heart Failure

Sponsor: Visiting Nurse Service of New York

Sex: All·Age: 18 - 101

Code: NCT07220798

Immersive Virtual Reality for Older Adults in Long-Term Care Settings

for Cognitive Impairment

Sponsor: Laval University

Sex: All·Age: 60+

Code: NCT07658287

Health Ahead Comparative Effectiveness Study

for Health Services Accessibility

1 site in Boulder

Sponsor: William Brandenburg, MD

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07669168

Apply to this trial

Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline

for Older Adults With Cognitive Decline

2 sites in Knoxville

Sponsor: The University of Tennessee, Knoxville

Sex: All·Age: 65+

Code: NCT07207993

Apply to this trial

Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)

for Dementia (Diagnosis)

Sponsor: Zealand University Hospital

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT07200739

MEVA Cognitive Wellness Platform Study for Adults

for Cognitive Wellness

Sponsor: Mentage LLC

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT07595250

Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2×2 Randomized Controlled Trial

for Intracranial Arteriosclerosis

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 55 - 80

Code: NCT07605130·Phase 4

Effect of Hot Spring Therapy on Central Fatigue Elimination During Altitude Training

for Central Fatigue

Sponsor: Macao Polytechnic University

Sex: All·Age: 12 - 16·Accepts healthy volunteers

Code: NCT07615478

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Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

for Ovarian Cancer

1 site in Orange

Sponsor: University of California, Irvine

Sex: Female·Age: 18+

Code: NCT04520139·Phase 1, Phase 2

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A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

for Cognitive Dysfunction

42 sites incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 55 - 85

Code: NCT07589595·Phase 2

Apply to this trial

Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults

for Cognitive Decline

Sponsor: Istanbul Medipol University Hospital

Sex: All·Age: 60+

Code: NCT07610109

Apply to this trial

Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty

for Postoperative Cognitive Dysfunction (POCD)

Sponsor: Odense University Hospital

Sex: All·Age: 70+

Code: NCT07598552

Apply to this trial

The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia

for Dementia Prevention

Sponsor: University of British Columbia

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07364019

Apply to this trial

Community-based Screening for Alzheimer's Disease

for Alzheimer's Disease(AD)

Sponsor: Kuang XiaoJun

Sex: All·Age: 60 - 80·Accepts healthy volunteers

Code: NCT07570719

Apply to this trial

Fareon Open Label Device Clinical Trial

for Cognitive Dysfunction

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 16+

Code: NCT07600320

Algal Lutein Against Decline of Intellectual Nimbleness

for Menopausal Syndrome

Sponsor: Poznan University of Life Sciences

Sex: Female·Age: 48 - 60·Accepts healthy volunteers

Code: NCT07600567

Cognitive Impact of Neoadjuvant Chemotherapy for Ovarian Cancer

for Ovarian Cancer

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: Female·Age: 18+

Code: NCT07125209

Apply to this trial

Human Observatory Study

for Aging

1 site in Boulder

Sponsor: Longevity Metrics, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07646782

Apply to this trial

Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic

for Frailty

Sponsor: Tomas Bata Hospital, Czech Republic

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07432009

Apply to this trial

Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

for Post Operative Delirium

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07610655

Apply to this trial

Efficacy of Bright Light Therapy on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms: Protocol for a Randomised Controlled Trial

for Major Depressive Disorder (MDD)

Sponsor: Peking University Sixth Hospital

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07508215

Apply to this trial

Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients

for Postoperative Delirium

Sponsor: Muğla Sıtkı Koçman University

Sex: All·Age: 65+

Code: NCT07719712

Apply to this trial

Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel Disease

for Cerebral Small Vessel Disease

Sponsor: Jiangsu Province Nanjing Brain Hospital

Sex: All·Age: 30 - 80

Code: NCT07317557

Tele-Rehabilitation vs Conventional Rehabilitation for Cognitive Improvement in Stroke Survivors.

for Stroke

Sponsor: Riphah International University

Sex: All·Age: 50 - 80

Code: NCT07504276

Apply to this trial

Brain Stimulation and Cognitive Training for MCI

for Mild Cognitive Impairment (MCI)

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT07526740

Apply to this trial

taVNS + CCT for Neurocognitive Rehab

for Psychosocial Well-being

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 45 - 80

Code: NCT07517237

Apply to this trial

Stem Cell Therapy for Early Alzheimer's Disease

for Cognitive Dysfunction

1 site in Houston

Sponsor: Paul E Schulz

Sex: All·Age: 60 - 80

Code: NCT06775964·Phase 1, Phase 2

Apply to this trial

Vortioxetine for Cognitive Function in ALK-positive NSCLC Treated With Lorlatinib

for Advanced ALK/ROS1-positive NSCLC

Sponsor: Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo

Sex: All·Age: 18+

Code: NCT07633626

Apply to this trial

TMS for Improving Cognitive Function in Bipolar Disorder

for Bipolar Disorder (BD)

Sponsor: First Affiliated Hospital of Zhejiang University

Sex: All·Age: 18 - 45

Code: NCT07414147

Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4

for Sleep Disturbance

Sponsor: Chang Gung Memorial Hospital

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07414680

Long-Term Effects of Walnut Consumption on Brain Function

for Healthy

Sponsor: Maastricht University Medical Center

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07422220

Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia

for Schizophrenia

Sponsor: Kit Wa Chan

Sex: All·Age: 18 - 60

Code: NCT07404319

Older Kidney Patient Optimisation Pretransplant

for Kidney Disease

Sponsor: Guy's and St Thomas' NHS Foundation Trust

Sex: All·Age: 60+

Code: NCT07419945

Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

for Insulin Resistance

1 site in San Francisco

Sponsor: SF Research Institute, Inc.

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT07220694

Apply to this trial

Cognitive Remediation

for Aging

1 site in Farmington

Sponsor: Cutter Lindbergh

Sex: All·Age: 60+

Code: NCT07171450

Apply to this trial

Eye Movement Parameters and Cognitive Functions in Older Adults

for Cognitive Dysfunction

Sponsor: National Sun Yat-sen University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07358598

China-NINE Cohort：Neuroimmune Network in Elderly / Neurodegeneration

for Cognitive Dysfunction

Sponsor: Yantai Yuhuangding Hospital

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT07586501

Cognitive impairment / decline clinical trials — common questions

Are cognitive impairment / decline clinical trials free to join?

Yes. Participating in a cognitive impairment / decline clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a cognitive impairment / decline clinical trial?

Each cognitive impairment / decline study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a cognitive impairment / decline trial near me?

Use the location controls above. We'll show recruiting cognitive impairment / decline trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many cognitive impairment / decline trials are recruiting right now?

We're currently tracking roughly 121 recruiting cognitive impairment / decline trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Cognitive impairment / decline trials by city

Birmingham, AL Boston, MA Gainesville, FL Los Angeles, CA San Francisco, CA Boulder, CO Chicago, IL Columbus, OH Indianapolis, IN Riverside, CA Urbana, IL Aurora, CO

Related specialties

Neurology Dementia care Brain disorders